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ZM 449829

ZM 449829 structure

CAS No.: 4452-06-6

Chemical Name:: ZM 449829

Synonyms: ZM 449829;JAK3 INHIBITOR V;2'-Acrylonaphthone;naphthyl vinyl ketone;2-NAPHTHYLVINYL KETONE;ZM 449829, JAK3 inhibitor;1-Naphthalen-2-yl-propenone;1-(2-Naphthyl)-2-propen-1-one;1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE;1-(Naphthalen-2-yl)prop-2-en-1-one

CBNumber:: CB2716532

Molecular Formula:: C13H10O

Molecular Weight:: 182.22

MDL Number:: MFCD04974535

MOL File:: 4452-06-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-28 08:09:15

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ZM 449829 Properties

Melting point	38-40 °C
Boiling point	319.3±15.0 °C(Predicted)
Density	1.093±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	White waxy solid
color	white
InChI	InChI=1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2
InChIKey	FOTCGZPFSUWZBN-UHFFFAOYSA-N
SMILES	C(C1=CC=C2C(=C1)C=CC=C2)(=O)C=C
UNSPSC Code	12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS08
Signal word	Danger
Hazard statements	H301-H311-H331-H341
Precautionary statements	P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

ZM 449829 price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	420122	JAK3 Inhibitor V - CAS 932258 - Calbiochem The JAK3 Inhibitor V, also referenced under CAS 932258, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.	4452-06-6	10mg	$308	2023-01-07	Buy
Cayman Chemical	32820	ZM 449829 ≥95%	4452-06-6	5mg	$95	2026-04-30	Buy
Cayman Chemical	32820	ZM 449829 ≥95%	4452-06-6	10mg	$168	2026-04-30	Buy
Cayman Chemical	32820	ZM 449829 ≥95%	4452-06-6	25mg	$392	2026-04-30	Buy
Cayman Chemical	32820	ZM 449829 ≥95%	4452-06-6	50mg	$739	2026-04-30	Buy

Product number	Packaging	Price	Buy
420122	10mg	$308	Buy
32820	5mg	$95	Buy
32820	10mg	$168	Buy
32820	25mg	$392	Buy
32820	50mg	$739	Buy

ZM 449829 Chemical Properties, Uses, Production

Uses

ZM 449829, is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. Also inhibits STAT-5 phosphorylation and T-cell proliferation.

Definition

ChEBI: 1-(2-naphthalenyl)-2-propen-1-one is a member of naphthalenes.

Biological Activity

Cell permeable: no', 'Product does not compete with ATP.', 'Reversible: no', 'pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1

IC 50

JAK3: 6.8 (pIC₅₀); JAK1: 4.7 (pIC₅₀); EGFR: 5.0 (pIC₅₀)

ZM 449829 synthesis

Synthesis of ZM 449829 from Formaldehyde and 2-Acetonaphthone

ZM 449829 Preparation Products And Raw materials

Raw materials

1-Propanone, 3-chloro-1-(2-naphthalenyl)- 2-Naphthalenemethanol, α-ethenyl- N-methoxy-N-methylnaphthalene-2-carboxamide 4,4,4-Trifluoro-1-(2-naphthyl)-1,3-butanedione 4-(2-Naphthyl)-4-oxobutanoicacid

2-Naphthoyl chloride Methanol Dimethyl sulfoxide 2-Acetonaphthone Formaldehyde

2-Naphthaldehyde N,N-Dimethylacetamide Vinylmagnesium bromide

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Preparation Products

ZM 449829 Suppliers

Global Suppliers ( 75)

Supplier	Tel	Email	Country	ProdList	Advantage
ChemeGen	18818260767	2625930290@qq.com	China	6966	58
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Shanghai HuanChuan Industry Co.,Ltd.	021-61478794	sales@hcshhai.com	China	9781	50
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8435	60
Zhengzhou Alfachem Co., Ltd.	0371-53765687 18937137882	3969243885@qq.com	China	7734	55
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9729	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58

Supplier	Advantage
ChemeGen	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
VDM Biochemicals	64
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
Bide Pharmatech Ltd.	60
Shanghai HuanChuan Industry Co.,Ltd.	50
EMMX Biotechnology LLC	60
Zhengzhou Alfachem Co., Ltd.	55
Shanghai Chaolan Chemical Technology Center	58
Amadis Chemical Company Limited	58

View Latest Price from ZM 449829 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-27	ZM 449829 4452-06-6	$297.00-1290.00			10g	TargetMol Chemicals Inc.

ZM 449829
4452-06-6
$297.00-1290.00
TargetMol Chemicals Inc.

ZM 449829 Spectrum

ZM 449829(4452-06-6)¹HNMR

4452-06-6 (ZM 449829) Related Search:

1,4-ANTHRAQUINONE α-Naphthoflavone 1,4-Chrysenequinone 3-(4-Methoxyphenyl)-1-(2-naphthyl)-prop-2-en-1-one 1-(2-Naphthyl)-3-(2-thienyl)-2-propen-1-one

α-Naphthoflavonol 3',4'-Dihydroxy-alpha-naphthoflavone 4'-Hydroxy-alpha-naphthoflavone 3-(4-Isopropylphenyl)-1-(2-naphthyl)prop-2-en-1-one Ethyl 2-(2,6-dibromo-4-[3-(2-naphthyl)-3-oxoprop-1-enyl]phenoxy)acetate

4'-Methoxy-alpha-naphthoflavone 2'-Methoxy-7,8-benzoflavone 4-[(E)-3-(2-naphthyl)-3-oxo-1-propenyl]phenyl 2-thiophenecarboxylate 3-(1,3-Benzodioxol-5-yl)-1-(2-naphthyl)prop-2-en-1-one 1-(2-Naphthyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one

3',4'-Dimethoxy-alpha-naphthoflavone 3-(2-Chlorophenyl)-1-(2-naphthyl)prop-2-en-1-one (E)-3-(2-Furyl)-1-(2-naphthyl)-2-propen-1-one

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2-NAPHTHYLVINYL KETONE 1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE JAK3 INHIBITOR V 2-Propen-1-one, 1-(2-naphthalenyl)- 1-Naphthalen-2-yl-propenone 1-(2-Naphthyl)-2-propen-1-one 2'-Acrylonaphthone ZM 449829 JAK3 Inhibitor V - CAS 932258 - Calbiochem 1-(Naphthalen-2-yl)prop-2-en-1-one naphthyl vinyl ketone ZM 449829, JAK3 inhibitor 4452-06-6 4452-6-6 Intracellular Signaling