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ZM 449829

ZM 449829 Structure
ZM 449829 structure
CAS No.
4452-06-6
Chemical Name:
ZM 449829
Synonyms
ZM 449829;JAK3 INHIBITOR V;2'-Acrylonaphthone;naphthyl vinyl ketone;2-NAPHTHYLVINYL KETONE;ZM 449829, JAK3 inhibitor;1-Naphthalen-2-yl-propenone;1-(2-Naphthyl)-2-propen-1-one;1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE;1-(Naphthalen-2-yl)prop-2-en-1-one
CBNumber:
CB2716532
Molecular Formula:
C13H10O
Molecular Weight:
182.22
MDL Number:
MFCD04974535
MOL File:
4452-06-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:44:58
Product description Number Pack Size Price
JAK3 Inhibitor V - CAS 932258 - Calbiochem
The JAK3 Inhibitor V, also referenced under CAS 932258, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. 		420122 10mg $308
ZM 449829 ≥95% 32820 5mg $95
ZM 449829 ≥95% 32820 10mg $168
ZM 449829 ≥95% 32820 25mg $392
ZM 449829 ≥95% 32820 50mg $739
Request For Quotation

ZM 449829 Properties

Boiling point 319.3±15.0 °C(Predicted)
Density 1.093±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form White waxy solid
color white
InChI InChI=1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2
InChIKey FOTCGZPFSUWZBN-UHFFFAOYSA-N
SMILES C(C1=CC=C2C(=C1)C=CC=C2)(=O)C=C
UNSPSC Code 12352200

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H311-H331-H341
Precautionary statements  P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

ZM 449829 price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 420122 JAK3 Inhibitor V - CAS 932258 - Calbiochem
The JAK3 Inhibitor V, also referenced under CAS 932258, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. 		4452-06-6 10mg $308 2023-01-07 Buy
Cayman Chemical 32820 ZM 449829 ≥95% 4452-06-6 5mg $95 2026-04-30 Buy
Cayman Chemical 32820 ZM 449829 ≥95% 4452-06-6 10mg $168 2026-04-30 Buy
Cayman Chemical 32820 ZM 449829 ≥95% 4452-06-6 25mg $392 2026-04-30 Buy
Cayman Chemical 32820 ZM 449829 ≥95% 4452-06-6 50mg $739 2026-04-30 Buy
Product number Packaging Price Buy
420122 10mg $308 Buy
32820 5mg $95 Buy
32820 10mg $168 Buy
32820 25mg $392 Buy
32820 50mg $739 Buy

ZM 449829 Chemical Properties,Uses,Production

Uses

ZM 449829, is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. Also inhibits STAT-5 phosphorylation and T-cell proliferation.

Definition

ChEBI: 1-(2-naphthalenyl)-2-propen-1-one is a member of naphthalenes.

Biological Activity

Cell permeable: no', 'Product does not compete with ATP.', 'Reversible: no', 'pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1

IC 50

JAK3: 6.8 (pIC50); JAK1: 4.7 (pIC50); EGFR: 5.0 (pIC50)

ZM 449829 synthesis

50-00-0
93-08-3
4452-06-6
Synthesis of ZM 449829 from Formaldehyde and 2-Acetonaphthone

ZM 449829 Preparation Products And Raw materials

Raw materials

1-Propanone, 3-chloro-1-(2-naphthalenyl)- 2-Naphthalenemethanol, α-ethenyl- N-methoxy-N-methylnaphthalene-2-carboxamide 4,4,4-TRIFLUORO-1-(2-NAPHTHYL)-1,3-BUTANEDIONE 4-(2-NAPHTHYL)-4-OXOBUTANOICACID
2-Naphthoyl chloride Methanol Dimethyl sulfoxide 2-Acetonaphthone Formaldehyde
2-Naphthaldehyde N,N-Dimethylacetamide Vinylmagnesium bromide

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Preparation Products

ZM 449829 Suppliers

Global( 75)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32466 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43333 58
Aladdin Scientific 		tp@aladdinsci.com United States 52923 58
DAYANG CHEM (HANGZHOU) CO.,LTD 		+86-88938639 +86-17705817739 info@dycnchem.com China 53803 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
ChemeGen 18818260767 2625930290@qq.com China 6973 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15838 69
BeiJing Hwrk Chemicals Limted 0757-86329057 18934348241 sales4.gd@hwrkchemical.com China 14063 55
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Shanghai Jian Chao Chemical Technology Co., Ltd. 150-2103-5486 18017383231 983544897@qq.com China 9340 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
DAYANG CHEM (HANGZHOU) CO.,LTD 		58
Amadis Chemical Company Limited 		58
ChemeGen 58
3B Pharmachem (Wuhan) International Co.,Ltd. 69
BeiJing Hwrk Chemicals Limted 55
VDM Biochemicals 64
Shanghai Jian Chao Chemical Technology Co., Ltd. 55

View Lastest Price from ZM 449829 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ZM 449829 pictures 2026-05-11 ZM 449829
4452-06-6
 $297.00-1290.00 10g TargetMol Chemicals Inc.
  • ZM 449829 pictures
  • ZM 449829
    4452-06-6
  • $297.00-1290.00
  • TargetMol Chemicals Inc.

ZM 449829 Spectrum

ZM 449829(4452-06-6)1HNMR

4452-06-6(ZM 449829)Related Search:

α-Naphthoflavone 1,4-CHRYSENEQUINONE 3-(4-METHOXYPHENYL)-1-(2-NAPHTHYL)-PROP-2-EN-1-ONE 1,4-ANTHRAQUINONE 1-(2-NAPHTHYL)-3-(2-THIENYL)-2-PROPEN-1-ONE
A-NAPHTHOFLAVONOL 4'-HYDROXY-ALPHA-NAPHTHOFLAVONE 3-(1,3-BENZODIOXOL-5-YL)-1-(2-NAPHTHYL)PROP-2-EN-1-ONE (E)-3-(2-FURYL)-1-(2-NAPHTHYL)-2-PROPEN-1-ONE 2'-METHOXY-7,8-BENZOFLAVONE
4'-METHOXY-ALPHA-NAPHTHOFLAVONE ETHYL 2-(2,6-DIBROMO-4-[3-(2-NAPHTHYL)-3-OXOPROP-1-ENYL]PHENOXY)ACETATE 1-(2-NAPHTHYL)-3-(3,4,5-TRIMETHOXYPHENYL)PROP-2-EN-1-ONE 3',4'-DIMETHOXY-ALPHA-NAPHTHOFLAVONE 4-[(E)-3-(2-naphthyl)-3-oxo-1-propenyl]phenyl 2-thiophenecarboxylate
3-(2-CHLOROPHENYL)-1-(2-NAPHTHYL)PROP-2-EN-1-ONE 3',4'-DIHYDROXY-ALPHA-NAPHTHOFLAVONE 3-(4-ISOPROPYLPHENYL)-1-(2-NAPHTHYL)PROP-2-EN-1-ONE

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2-NAPHTHYLVINYL KETONE 1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE JAK3 INHIBITOR V 2-Propen-1-one, 1-(2-naphthalenyl)- 1-Naphthalen-2-yl-propenone 1-(2-Naphthyl)-2-propen-1-one 2'-Acrylonaphthone ZM 449829 JAK3 Inhibitor V - CAS 932258 - Calbiochem 1-(Naphthalen-2-yl)prop-2-en-1-one naphthyl vinyl ketone ZM 449829, JAK3 inhibitor 4452-06-6 4452-6-6 Intracellular Signaling