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ZM 449829

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ZM 449829 manufacturers

  • ZM 449829
  • ZM 449829 pictures
  • $297.00
  • 2026-07-27
  • CAS:4452-06-6
  • Purity:
  • Supply Ability: 10g
ZM 449829 Basic information
Product Name:ZM 449829
Synonyms:2-NAPHTHYLVINYL KETONE;1-(2-NAPHTHALENYL)-2-PROPEN-1-ONE;JAK3 INHIBITOR V;2-Propen-1-one, 1-(2-naphthalenyl)-;1-Naphthalen-2-yl-propenone;1-(2-Naphthyl)-2-propen-1-one;2'-Acrylonaphthone;ZM 449829
CAS:4452-06-6
MF:C13H10O
MW:182.22
EINECS:
Product Categories:Intracellular Signaling
Mol File:4452-06-6.mol
ZM 449829 Structure
ZM 449829 Chemical Properties
Melting point 38-40 °C
Boiling point 319.3±15.0 °C(Predicted)
density 1.093±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form White waxy solid
color white
InChIInChI=1S/C13H10O/c1-2-13(14)12-8-7-10-5-3-4-6-11(10)9-12/h2-9H,1H2
InChIKeyFOTCGZPFSUWZBN-UHFFFAOYSA-N
SMILESC(C1=CC=C2C(=C1)C=CC=C2)(=O)C=C
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
ZM 449829 Usage And Synthesis
UsesZM 449829, is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site. Also inhibits STAT-5 phosphorylation and T-cell proliferation.
DefinitionChEBI: 1-(2-naphthalenyl)-2-propen-1-one is a member of naphthalenes.
Biological ActivityCell permeable: no', 'Product does not compete with ATP.', 'Reversible: no', 'pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1
IC 50JAK3: 6.8 (pIC50); JAK1: 4.7 (pIC50); EGFR: 5.0 (pIC50)
Tag:ZM 449829(4452-06-6) Related Product Information
1,4-Chrysenequinone 3-(4-METHOXYPHENYL)-1-(2-NAPHTHYL)-PROP-2-EN-1-ONE α-Naphthoflavone 1,4-ANTHRAQUINONE 1-(2-NAPHTHYL)-3-(2-THIENYL)-2-PROPEN-1-ONE α-Naphthoflavonol 3',4'-Dihydroxy-alpha-naphthoflavone 4'-Hydroxy-alpha-naphthoflavone 3-(4-Isopropylphenyl)-1-(2-naphthyl)prop-2-en-1-one Ethyl 2-(2,6-dibromo-4-[3-(2-naphthyl)-3-oxoprop-1-enyl]phenoxy)acetate 4'-Methoxy-alpha-naphthoflavone 2'-Methoxy-7,8-benzoflavone 3-(1,3-BENZODIOXOL-5-YL)-1-(2-NAPHTHYL)PROP-2-EN-1-ONE (E)-3-(2-FURYL)-1-(2-NAPHTHYL)-2-PROPEN-1-ONE 1-(2-NAPHTHYL)-3-(3,4,5-TRIMETHOXYPHENYL)PROP-2-EN-1-ONE 3',4'-DIMETHOXY-ALPHA-NAPHTHOFLAVONE 4-[(E)-3-(2-naphthyl)-3-oxo-1-propenyl]phenyl 2-thiophenecarboxylate 3-(2-CHLOROPHENYL)-1-(2-NAPHTHYL)PROP-2-EN-1-ONE