1-Amino-2-(isopropylsulphonyl)benzene
- CAS No.
- 76697-50-2
- Chemical Name:
- 1-Amino-2-(isopropylsulphonyl)benzene
- Synonyms
- 2-(isopropylsulfonyl)aniline;2-(isopropylsulfonyl)a;2-propan-2-ylsulfonylaniline;2-(Isopropylsulphonyl)aniline;2-(propane-2-sulfonyl)aniline;362-(IsoPropylsulfonyl)Aniline;2-AMinophenyl Isopropyl Sulfone;2-(isopropylsulfonyl)benzenaMine;2-(Isopropylsulphonyl)aniline 98%;2-(Propane-2-sulfonyl)-phenylaMine
- CBNumber:
- CB2727345
- Molecular Formula:
- C9H13NO2S
- Molecular Weight:
- 199.27
- MDL Number:
- MFCD08445603
- MOL File:
- 76697-50-2.mol
- MSDS File:
- SDS
| Melting point | 83.0 to 87.0 °C |
|---|---|
| Boiling point | 381.1±34.0 °C(Predicted) |
| Density | 1.194±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | solid |
| pka | -0.79±0.10(Predicted) |
| color | Beige |
| InChI | InChI=1S/C9H13NO2S/c1-7(2)13(11,12)9-6-4-3-5-8(9)10/h3-7H,10H2,1-2H3 |
| InChIKey | GMLAMRMKROYXNZ-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=CC=C1S(C(C)C)(=O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2930909899 | |||||||||
| NFPA 704 |
|
1-Amino-2-(isopropylsulphonyl)benzene price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | I1033 | 2-(Isopropylsulfonyl)aniline >98.0%(GC) | 76697-50-2 | 1g | $40 | 2026-04-30 | Buy |
| TCI Chemical | I1033 | 2-(Isopropylsulfonyl)aniline >98.0%(GC) | 76697-50-2 | 5g | $121 | 2026-04-30 | Buy |
| AstaTech | 62882 | 2-(ISOPROPYLSULPHONYL)ANILINE 97% | 76697-50-2 | 1G | $17 | 2026-04-30 | Buy |
| AstaTech | 62882 | 2-(ISOPROPYLSULPHONYL)ANILINE 97% | 76697-50-2 | 5G | $21 | 2026-04-30 | Buy |
| Activate Scientific | AS35652 | 1-Amino-2-(isopropylsulphonyl)benzene 95% | 76697-50-2 | 5g | $31 | 2026-06-04 | Buy |
1-Amino-2-(isopropylsulphonyl)benzene Chemical Properties, Uses, Production
Uses
2-Aminophenyl Isopropyl Sulfone is a reagent used in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment.
Synthesis
70415-86-0
76697-50-2
Step 3: Preparation of 2-(isopropylsulfonyl)aniline (4); 1-(isopropylsulfonyl)-2-nitrobenzene (3, 2 g, 8.73 mmol) was dissolved in methanol (25 ml) to form a homogeneous mixture. 10% palladium carbon (200 mg, 10 mol%) was added to the mixture and the reaction mixture was stirred under hydrogen atmosphere for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) to confirm the complete conversion of feedstock 3 to product 4. Upon completion of the reaction, the mixture was filtered through diatomaceous earth, and the filtrate was concentrated under reduced pressure to afford 2-(isopropylsulfonyl)aniline (4, 1.73 g, quantitative yield).' HNMR (CDCl3): δ 7.66-7.62 (d, 1H), 7.40-7.30 (t, 1H), 6.85-6.78 (t, 1H), 6.73-6.70 (d, 1H), 5.10 (br s, 1H), 3.40-3.30 (m, 1H), 1.30 (s, 6H).
References
[1] Patent: WO2011/140338, 2011, A1. Location in patent: Page/Page column 46-47
[2] Patent: CN106854200, 2017, A. Location in patent: Paragraph 0064
[3] Patent: CN106146468, 2016, A. Location in patent: Paragraph 0088; 0101; 0102
[4] Patent: CN106336382, 2017, A. Location in patent: Paragraph 0099; 0141; 0142; 0143
[5] Patent: US2018/57457, 2018, A1. Location in patent: Paragraph 0260; 0262
1-Amino-2-(isopropylsulphonyl)benzene Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan XuanDe Chemical Co., Ltd. | 0531-88803958 19862127196 | zhangxu@shiningpharm.com | China | 201 | 58 |
| Hangzhou Dingxin Biotechnology Co., Ltd. | 0571-88194596 15558156576 | sales@disynchem.com | China | 94 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Tetranov Biopharm | 13526569071 | sales@leadmedpharm.com | China | 7881 | 64 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 1-Amino-2-(isopropylsulphonyl)benzene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-26 | 2-(Isopropylsulfonyl)aniline
76697-50-2
|
99%(HPLC) | 5000kg/Year | Nanjing Fred Technology Co., Ltd | |||
 |
2023-05-04 | 2-(isopropyl sulfonyl) aniline
7669-50-2
|
$40.00-48.00 | 10公斤 | 99% | 200tons | Guangzhou Sunton Biotechnology Co., Ltd. | |
 |
2019-07-06 | 1-AMINO-2-(ISOPROPYLSULPHONYL)BENZENE
76697-50-2
|
$100.00 | 1KG | 98% | 100KG | Career Henan Chemical Co |
-
- 2-(Isopropylsulfonyl)aniline
76697-50-2
- 99%(HPLC)
- Nanjing Fred Technology Co., Ltd
-
- 2-(isopropyl sulfonyl) aniline
7669-50-2
- $40.00-48.00
- 99%
- Guangzhou Sunton Biotechnology Co., Ltd.
-
- 1-AMINO-2-(ISOPROPYLSULPHONYL)BENZENE
76697-50-2
- $100.00
- 98%
- Career Henan Chemical Co
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