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Ethyl 3-amino-4,4,4-trifluorocrotonate

Ethyl 3-amino-4,4,4-trifluorocrotonate structure

CAS No.: 372-29-2

Chemical Name:: Ethyl 3-amino-4,4,4-trifluorocrotonate

Synonyms: Ethyl 3-amino-4,4,4-trifluorocrotote;Ethyl 3-amino-4;trifluorocrotonate;4-trifluorocrotonate;ETHYL 3-AMINO-4,4,4-TRIFLUOROCROTONATE;ethyl 3-amino-4,4,4-trifluro crotonate;3-Amino-4,4,4-trifluorobutenoate ethyl;Ethyl3-amino-4,4,4-trifluorocrotonate97%;ETHYL 3-AMINO-4,4,4-TRIFLUOROBUT-2-ENOATE;ETHYL 3-AMINO-4,4,4-TRIFLUORO-2-BUTENOATE

CBNumber:: CB2742977

Molecular Formula:: C6H8F3NO2

Molecular Weight:: 183.13

MDL Number:: MFCD00068195

MOL File:: 372-29-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:48:02

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Ethyl 3-amino-4,4,4-trifluorocrotonate Properties

Melting point	26°C
Boiling point	83 °C15 mm Hg(lit.)
Density	1.245 g/mL at 25 °C(lit.)
refractive index	n20/D 1.424(lit.)
Flash point	149 °F
storage temp.	2-8°C(protect from light)
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Colourless to Pale Yellow Low-Melting to Semi-Solid
pka	0.76±0.70(Predicted)
color	White or Colorless to Light yellow
FreezingPoint	22.0 to 26.0 ℃
Sensitive	Air Sensitive
BRN	4397839
InChI	1S/C6H8F3NO2/c1-2-12-5(11)3-4(10)6(7,8)9/h3H,2,10H2,1H3
InChIKey	NXVKRKUGIINGHD-ONEGZZNKSA-N
SMILES	CCOC(=O)C=C(N)C(F)(F)F
CAS DataBase Reference	372-29-2(CAS DataBase Reference)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS05

Signal word

Warning

Hazard statements

H302+H312-H319-H335-H314-H318-H315

Precautionary statements

P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P301+P312+P330-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,T,Xi

Risk Statements

20/21/22-36/37

Safety Statements

26-36-36/37

RIDADR

3259

WGK Germany

Hazard Note

Toxic/Irritant

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29224999

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Eye Irrit. 2
STOT SE 3

NFPA 704

	2
2		0

Ethyl 3-amino-4,4,4-trifluorocrotonate price More Price(45)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	443697	Ethyl 3-amino-4,4,4-trifluorocrotonate 96%	372-29-2	10G	$44.6	2023-01-07	Buy
TCI Chemical	A1475	Ethyl 3-Amino-4,4,4-trifluorocrotonate >97.0%(GC)	372-29-2	5g	$23	2026-04-30	Buy
TCI Chemical	A1475	Ethyl 3-Amino-4,4,4-trifluorocrotonate >97.0%(GC)	372-29-2	25g	$61	2026-04-30	Buy
TRC	TRC-E899680-500MG	Ethyl 3-amino-4,4,4-trifluorocrotonate	372-29-2	500mg	$65	2026-06-03	Buy
TRC	TRC-E899680-2.5G	Ethyl 3-amino-4,4,4-trifluorocrotonate	372-29-2	2.5g	$84	2026-06-03	Buy

Product number	Packaging	Price	Buy
443697	10G	$44.6	Buy
A1475	5g	$23	Buy
A1475	25g	$61	Buy
TRC-E899680-500MG	500mg	$65	Buy
TRC-E899680-2.5G	2.5g	$84	Buy

Ethyl 3-amino-4,4,4-trifluorocrotonate Chemical Properties, Uses, Production

Chemical Properties

Colourless liquid or white solid

Uses

Ethyl 3-amino-4,4,4-trifluorocrotonate is used as building block in chemical synthesis. Attributes Development Product Contact

Synthesis

383-63-1

141-78-6

372-29-2

A slurry of sodium enolides was prepared from ethyl trifluoroacetate (88.1 g, 1.0 mol) and ethyl acetate (71.05 g, 0.50 mol) by mixing with solid sodium ethoxide (34.05 g, 0.5 mol). The mixture was evaporated and concentrated with reference to the operation of Example 1. Subsequently, 250 ml of cyclohexane was added to the reaction system, followed by ammonium acetate (77.1 g, 1.0 mol) and anhydrous acetic acid (39.0 g, 0.65 mol). The resulting suspension was heated to boiling, water was separated by distillation and cyclohexane was refluxed into the reaction mixture. The reaction was terminated after 5 hours. The organic phase was separated by adding 300 mL of water. Cyclohexane was removed from the organic phase by distillation and the product was subsequently fractionated under vacuum. 57.0 g of ethyl 3-amino-4,4,4-trifluorobut-2-enoate was obtained with 97.4% purity and 62% yield. The product was analyzed by EI mass spectrometry ([M+] = 183 AMU), 1H-NMR (7.6 ppm, NH; 4.86 ppm, 1H, CH; 4.08 ppm, Quadruple peak, 2H, ethyl; 1.18 ppm, Triple peak, 3H, ethyl) and 13C-NMR (168 ppm, COOEt; 147 ppm, Quadruple peak, C-NH2. 120 ppm, broad quadruple peak, CF3; 82 ppm, quadruple peak, CH; 59 ppm, ethyl; 14 ppm, ethyl) were characterized.

References

[1] Patent: WO2004/16579, 2004, A1. Location in patent: Page 9; 10

Ethyl 3-amino-4,4,4-trifluorocrotonate Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Ammonium hydroxide Ethanol Ammonium acetate Ethyl trifluoroacetate

Ethyl acetate Acetic acid Cyclohexane

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Preparation Products

Ethyl 3-amino-4,4,4-trifluorocrotonate Suppliers

Global Suppliers ( 376)

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Wanxingda New Material Technology Co., Ltd.	0531-88064106 18253116016	zhangjia@wxdchem.com	China	44	58
Shandong Zhanhua Yonghao Pharmaceutical Technology Co., Ltd	0576-88685096 13989620089	sales@yfchem.cn	China	7	65
Shanghai Yihe Biological Technology Co., Ltd.	021-68882955 17721395025	2423903095@qq.com	China	4999	58
Ningbo Jiaheshan New Material Co., LTD	13758655631	2573039014@qq.com	China	18	58
Jinan Langhua Chemical Co., Ltd	0531-85906691 18660816586	325912681@qq.com	China	212	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
Jinan Wanxingda New Material Technology Co., Ltd.	58
Shandong Zhanhua Yonghao Pharmaceutical Technology Co., Ltd	65
Shanghai Yihe Biological Technology Co., Ltd.	58
Ningbo Jiaheshan New Material Co., LTD	58
Jinan Langhua Chemical Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56

View Latest Price from Ethyl 3-amino-4,4,4-trifluorocrotonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-25	Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2	$2.00-5.00	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-05-28	Ethyl 3-Amino-4, 4, 4-Trifluorocrotonate 372-29-2	$2.00-5.00	1KG	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2026-03-20	Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2		1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd

Ethyl 3-amino-4,4,4-trifluorocrotonate
372-29-2
$2.00-5.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Ethyl 3-Amino-4, 4, 4-Trifluorocrotonate
372-29-2
$2.00-5.00
99%
Hebei Chuanghai Biotechnology Co,.LTD

Ethyl 3-amino-4,4,4-trifluorocrotonate
372-29-2
99%
Hebei Chuanghai Biotechnology Co., Ltd

Ethyl 3-amino-4,4,4-trifluorocrotonate Spectrum

Ethyl 3-amino-4,4,4-trifluorocrotonate(372-29-2)MS Ethyl 3-amino-4,4,4-trifluorocrotonate(372-29-2)¹HNMR Ethyl 3-amino-4,4,4-trifluorocrotonate(372-29-2)¹³CNMR Ethyl 3-amino-4,4,4-trifluorocrotonate(372-29-2)IR1

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4-trifluorocrotonate Ethyl 3-amino-4 Ethyl 3-amino-4,4,4-trifluorocrotonate, 98.5% 3-Amino-4,4,4-trifluor-crotonsaeure-aethylester ETHYL 3-AMINO-4,4,4-TRIFLUORO-2-BUTENOATE ETHYL 3-AMINO-4,4,4-TRIFLUOROBUT-2-ENOATE ETHYL 3-AMINO-4,4,4-TRIFLUOROCROTONATE 2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUORO, ETHYL ESTER 3-AMINO-4,4,4-TRIFLUOROCROTONIC ACID ETHYL ESTER 3-AMINO-4,4,4-TRIFLUOROCROTONIC ETHYL ESTER Ethyl 3-Amino-4,4,4-Trifluorocrotonate Ethyl 3-Amino-4,4,4-Trifluoro-2-Butenoate Ethyl 3-amino-4,4,4-trifluorocrotonate 97% Ethyl3-amino-4,4,4-trifluorocrotonate97% Ethyl 3-amino-4,4,4-trifluorocrotonate,96% 2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUOR Ethyl 3-amino-4,4,4-trifluorocrotonate ,99% ethyl (2Z)-3-aMino-4,4,4-trifluorobut-2-enoate (Z)-ethyl 3-aMino-4,4,4-trifluorobut-2-enoate Ethyl 3-Amino-4,4,4-trifluorocrotonate > 3- Amino-4,4, 4-trifluorobartanate, ethyl ester TIANFU CHEM---Ethyl 3-amino-4,4,4-trifluorocrotonate ethyl 3-amino-4,4,4-trifluro crotonate 3-Amino-4,4,4-trifluoroprotonate ethyl ester 3-Amino-4,4,4-trifluorobutenoate ethyl Ethyl 3-amino-4,4,4-trifluorocrotote trifluorocrotonate 372-29-2 C6H8F3NO2 C6H8NO2F3 CF3CNH2CHCO2C2H5 Building Blocks Carbonyl Compounds C6 to C7 AMINE Organic Building Blocks Esters Fluorinated ketene derivatives Ketene derivatives