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Ethyl 3-amino-4,4,4-trifluorocrotonate

Ethyl 3-amino-4,4,4-trifluorocrotonate structure

CAS No.: 372-29-2

Chemical Name:: Ethyl 3-amino-4,4,4-trifluorocrotonate

Synonyms: Ethyl 3-amino-4;4-trifluorocrotonate;Ethyl 3-amino-4,4,4-trifluorocrotote;ETHYL 3-AMINO-4,4,4-TRIFLUOROCROTONATE;ethyl 3-amino-4,4,4-trifluro crotonate;3-Amino-4,4,4-trifluorobutenoate ethyl;Ethyl3-amino-4,4,4-trifluorocrotonate97%;ETHYL 3-AMINO-4,4,4-TRIFLUOROBUT-2-ENOATE;ETHYL 3-AMINO-4,4,4-TRIFLUORO-2-BUTENOATE;2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUOR

CBNumber:: CB2742977

Molecular Formula:: C6H8F3NO2

Molecular Weight:: 183.13

MDL Number:: MFCD00068195

MOL File:: 372-29-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:46

Product description	Number	Pack Size	Price
Ethyl 3-amino-4,4,4-trifluorocrotonate 96%	443697	10G	$44.6
Ethyl 3-Amino-4,4,4-trifluorocrotonate >97.0%(GC)	A1475	5g	$23
Ethyl 3-Amino-4,4,4-trifluorocrotonate >97.0%(GC)	A1475	25g	$61
Ethyl 3-amino-4,4,4-trifluorocrotonate ≥97%(GC)	45244	5G	$48.77
Ethyl 3-amino-4,4,4-trifluorocrotonate ≥97%(GC)	45244	25G	$165.65
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Ethyl 3-amino-4,4,4-trifluorocrotonate Properties

Melting point	26°C
Boiling point	83 °C15 mm Hg(lit.)
Density	1.245 g/mL at 25 °C(lit.)
refractive index	n20/D 1.424(lit.)
Flash point	149 °F
storage temp.	2-8°C(protect from light)
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	0.76±0.70(Predicted)
form	Colourless to Pale Yellow Low-Melting to Semi-Solid
color	White or Colorless to Light yellow
FreezingPoint	22.0 to 26.0 ℃
Sensitive	Air Sensitive
BRN	4397839
InChI	1S/C6H8F3NO2/c1-2-12-5(11)3-4(10)6(7,8)9/h3H,2,10H2,1H3
InChIKey	NXVKRKUGIINGHD-ONEGZZNKSA-N
SMILES	CCOC(=O)C=C(N)C(F)(F)F
CAS DataBase Reference	372-29-2(CAS DataBase Reference)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS05

Signal word

Warning

Hazard statements

H302+H312-H319-H335-H314-H318-H315

Precautionary statements

P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P260h-P301+P330+P331-P303+P361+P353-P405-P501a-P280-P301+P312+P330-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Xn,T,Xi

Risk Statements

20/21/22-36/37

Safety Statements

26-36-36/37

RIDADR

3259

WGK Germany

Hazard Note

Toxic/Irritant

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29224999

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Dermal
Acute Tox. 4 Oral
Eye Irrit. 2
STOT SE 3

NFPA 704

	2
2		0

Ethyl 3-amino-4,4,4-trifluorocrotonate price More Price(38)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	443697	Ethyl 3-amino-4,4,4-trifluorocrotonate 96%	372-29-2	10G	$44.6	2023-01-07	Buy
TCI Chemical	A1475	Ethyl 3-Amino-4,4,4-trifluorocrotonate >97.0%(GC)	372-29-2	5g	$23	2026-04-30	Buy
TCI Chemical	A1475	Ethyl 3-Amino-4,4,4-trifluorocrotonate >97.0%(GC)	372-29-2	25g	$61	2026-04-30	Buy
Chem-Impex	45244	Ethyl 3-amino-4,4,4-trifluorocrotonate ≥97%(GC)	372-29-2	5G	$48.77	2026-05-19	Buy
Chem-Impex	45244	Ethyl 3-amino-4,4,4-trifluorocrotonate ≥97%(GC)	372-29-2	25G	$165.65	2026-05-19	Buy

Product number	Packaging	Price	Buy
443697	10G	$44.6	Buy
A1475	5g	$23	Buy
A1475	25g	$61	Buy
45244	5G	$48.77	Buy
45244	25G	$165.65	Buy

Ethyl 3-amino-4,4,4-trifluorocrotonate Chemical Properties,Uses,Production

Chemical Properties

Colourless liquid or white solid

Uses

Ethyl 3-amino-4,4,4-trifluorocrotonate is used as building block in chemical synthesis. Attributes Development Product Contact

Synthesis

383-63-1

141-78-6

372-29-2

A slurry of sodium enolides was prepared from ethyl trifluoroacetate (88.1 g, 1.0 mol) and ethyl acetate (71.05 g, 0.50 mol) by mixing with solid sodium ethoxide (34.05 g, 0.5 mol). The mixture was evaporated and concentrated with reference to the operation of Example 1. Subsequently, 250 ml of cyclohexane was added to the reaction system, followed by ammonium acetate (77.1 g, 1.0 mol) and anhydrous acetic acid (39.0 g, 0.65 mol). The resulting suspension was heated to boiling, water was separated by distillation and cyclohexane was refluxed into the reaction mixture. The reaction was terminated after 5 hours. The organic phase was separated by adding 300 mL of water. Cyclohexane was removed from the organic phase by distillation and the product was subsequently fractionated under vacuum. 57.0 g of ethyl 3-amino-4,4,4-trifluorobut-2-enoate was obtained with 97.4% purity and 62% yield. The product was analyzed by EI mass spectrometry ([M+] = 183 AMU), 1H-NMR (7.6 ppm, NH; 4.86 ppm, 1H, CH; 4.08 ppm, Quadruple peak, 2H, ethyl; 1.18 ppm, Triple peak, 3H, ethyl) and 13C-NMR (168 ppm, COOEt; 147 ppm, Quadruple peak, C-NH2. 120 ppm, broad quadruple peak, CF3; 82 ppm, quadruple peak, CH; 59 ppm, ethyl; 14 ppm, ethyl) were characterized.

References

[1] Patent: WO2004/16579, 2004, A1. Location in patent: Page 9; 10

Ethyl 3-amino-4,4,4-trifluorocrotonate Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Ammonium hydroxide Ethanol Ammonium acetate Ethyl trifluoroacetate

Ethyl acetate Acetic acid Cyclohexane

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Preparation Products

Ethyl 3-amino-4,4,4-trifluorocrotonate Suppliers

Global( 363)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8738	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5233	58
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	sales@aochuangchem.com	China	9333	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13901	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29815	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58

Supplier	Advantage
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Henan Aochuang Chemical Co.,Ltd.	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58

View Lastest Price from Ethyl 3-amino-4,4,4-trifluorocrotonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2	US $2.00-5.00 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-03-20	Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2	US $0.00-0.00 / KG	1KG	99%	20 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-12-25	Ethyl 3-amino-4,4,4-trifluorocrotonate 372-29-2	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

Ethyl 3-amino-4,4,4-trifluorocrotonate
372-29-2
US $2.00-5.00 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Ethyl 3-amino-4,4,4-trifluorocrotonate
372-29-2
US $0.00-0.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Ethyl 3-amino-4,4,4-trifluorocrotonate
372-29-2
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

Ethyl 3-amino-4,4,4-trifluorocrotonate Spectrum

Ethyl 3-amino-4,4,4-trifluorocrotonate(372-29-2)MS Ethyl 3-amino-4,4,4-trifluorocrotonate(372-29-2)¹HNMR Ethyl 3-amino-4,4,4-trifluorocrotonate(372-29-2)¹³CNMR Ethyl 3-amino-4,4,4-trifluorocrotonate(372-29-2)IR1

372-29-2(Ethyl 3-amino-4,4,4-trifluorocrotonate)Related Search:

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Ethyl 3-amino-4,4,4-trifluorocrotote 4-trifluorocrotonate Ethyl 3-amino-4 Ethyl 3-amino-4,4,4-trifluorocrotonate, 98.5% 3-Amino-4,4,4-trifluor-crotonsaeure-aethylester ETHYL 3-AMINO-4,4,4-TRIFLUORO-2-BUTENOATE ETHYL 3-AMINO-4,4,4-TRIFLUOROBUT-2-ENOATE ETHYL 3-AMINO-4,4,4-TRIFLUOROCROTONATE 2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUORO, ETHYL ESTER 3-AMINO-4,4,4-TRIFLUOROCROTONIC ACID ETHYL ESTER 3-AMINO-4,4,4-TRIFLUOROCROTONIC ETHYL ESTER Ethyl 3-Amino-4,4,4-Trifluorocrotonate Ethyl 3-Amino-4,4,4-Trifluoro-2-Butenoate Ethyl 3-amino-4,4,4-trifluorocrotonate 97% Ethyl3-amino-4,4,4-trifluorocrotonate97% Ethyl 3-amino-4,4,4-trifluorocrotonate,96% 2-BUTENOIC ACID, 3-AMINO-4,4,4-TRIFLUOR Ethyl 3-amino-4,4,4-trifluorocrotonate ,99% ethyl (2Z)-3-aMino-4,4,4-trifluorobut-2-enoate (Z)-ethyl 3-aMino-4,4,4-trifluorobut-2-enoate Ethyl 3-Amino-4,4,4-trifluorocrotonate > 3- Amino-4,4, 4-trifluorobartanate, ethyl ester TIANFU CHEM---Ethyl 3-amino-4,4,4-trifluorocrotonate ethyl 3-amino-4,4,4-trifluro crotonate 3-Amino-4,4,4-trifluoroprotonate ethyl ester 3-Amino-4,4,4-trifluorobutenoate ethyl 372-29-2 C6H8F3NO2 C6H8NO2F3 CF3CNH2CHCO2C2H5 Building Blocks Carbonyl Compounds C6 to C7 AMINE Organic Building Blocks Esters Fluorinated ketene derivatives Ketene derivatives