ISOLIQUIRITIN
- CAS No.
- 5041-81-6
- Chemical Name:
- ISOLIQUIRITIN
- Synonyms
- Isoliquiritoside;neoisoliquritin;(E)-1-(2,4-Dihydroxyphenyl)-3-(4-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)prop-2-en-1-one;Aids004475;Aids-004475;ISOLIQUIRITIN;Isoliquiriiin;Isoliquiritin-RM;Isoliquiritin, >=98%;ISOLIQUIRITIN USP/EP/BP
- CBNumber:
- CB2765101
- Molecular Formula:
- C21H22O9
- Molecular Weight:
- 418.39
- MDL Number:
- MFCD00272145
- MOL File:
- 5041-81-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 185-186℃ |
|---|---|
| Boiling point | 743.5±60.0 °C(Predicted) |
| Density | 1.528 |
| storage temp. | 4°C, protect from light |
| solubility | Soluble in methan |
| form | powder |
| pka | 7.46±0.35(Predicted) |
| color | Ochre |
| biological source | plant |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| InChI | InChI=1/C21H22O9/c22-10-17-18(26)19(27)20(28)21(30-17)29-13-5-1-11(2-6-13)3-8-15(24)14-7-4-12(23)9-16(14)25/h1-9,17-23,25-28H,10H2/b8-3+/t17-,18-,19+,20-,21-/s3 |
| InChIKey | YNWXJFQOCHMPCK-RQOZFYCLNA-N |
| SMILES | [C@@H]1([C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O)OC1=CC=C(/C=C/C(=O)C2C=CC(O)=CC=2O)C=C1 |&1:0,1,3,4,6,r| |
| FDA UNII | 2Y348H1V4W |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
ISOLIQUIRITIN price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB01045 | Isoliquiritin ≥90% (LC/MS-ELSD) | 5041-81-6 | 1mg | $334 | 2026-04-30 | Buy |
| TCI Chemical | I1144 | Isoliquiritin | 5041-81-6 | 25MG | $238 | 2026-04-30 | Buy |
| Cayman Chemical | 30270 | Isoliquiritin ≥98% | 5041-81-6 | 5mg | $196 | 2026-04-30 | Buy |
| Cayman Chemical | 30270 | Isoliquiritin ≥98% | 5041-81-6 | 10mg | $351 | 2026-04-30 | Buy |
| Cayman Chemical | 30270 | Isoliquiritin ≥98% | 5041-81-6 | 25mg | $631 | 2026-04-30 | Buy |
ISOLIQUIRITIN Chemical Properties, Uses, Production
Chemical Properties
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from licorice.
Uses
It is a natural product derived from plant source th at finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Definition
ChEBI: A monosaccharide derivative that is trans-chalcone substituted by hydroxy groups at positions 2' and 4' and a beta-D-glucopyranosyloxy group at position 4 respectively.
Biological Activity
Isoliquiritin triggers apoptotic cell death by increasing the levels of p53 and p21 in A549 non-small cell lung cancer cells while also inhibiting the p53-dependent pathway and revealing interactions with Akt activities. Futher, Isoliquiritin has demonstrated neuroprotective activity against oxidative stress and has the capability to restrain the growth of microbial pathogens.
in vivo
Isoliquiritin (0.31-3.1 mg/kg, i.p., once a day for 5 days) inhibits granuloma angiogenesis in mice[1].
Isoliquiritin (10-40 mg/kg, oral gavage) shows antidepressant-like effects in FST and TST tests in mice[2].
Isoliquiritin ((10 mg/kg/bw/day, p.o.) shows anti-oxidative and anti-Inflammatory properties, and relieves cationic BSA-Induced membranous glomerulonephritis in experimental rat model[5].
| Animal Model: | Mice in Forced Swimming Test (FST) and the Tail Suspension Test (TST)[2] |
| Dosage: | 10, 20 and 40 mg/kg |
| Administration: | oral gavage |
| Result: | Reduced the immobility time in the FST and TST in mice. Increased 5-HT and NE level and Reduced the ratio of 5-HIAA/5-HT in the hippocampus, hypothalamus and cortex. |
target
HIV
ISOLIQUIRITIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Aktin Chemicals, Inc. | 86-28-85159085 | info@aktinchem.com | China | 297 | 62 |
| Shenzhen Sungening Bio-Tech Co., Ltd | +86-0755-89668383 | sales@sungening.com | China | 1319 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Chengdu Climax Biotech Co., Ltd. | 028-83311324 1278112614 | climaxbiotech@gmail.com | China | 925 | 58 |
View Latest Price from ISOLIQUIRITIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Isoliquiritin
5041-81-6
|
$39.00-123.00 | 98.65% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Isoliquiritin
5041-81-6
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2021-07-13 | isoliquiritin
5041-81-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Isoliquiritin
5041-81-6
- $39.00-123.00
- 98.65%
- TargetMol Chemicals Inc.
-
- Isoliquiritin
5041-81-6
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- isoliquiritin
5041-81-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
