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4,4'-Oxybis(phenyl isocyanate)

CAS No.
4128-73-8
Chemical Name:
4,4'-Oxybis(phenyl isocyanate)
Synonyms
OXYBIS(4-PHENYL ISOCYANATE);4,4'-Oxybis(isocyanatobenzene);4,4'-Oxybis(phenyl isocyanate);4,4'-diisocyanatodiphenyl ether;1,1’-oxybis[4-isocyanato-benzen;4,4'-Bis(isocyanatophenyl)oxide;Oxybis(4-phenyl isocyanate),99%;Oxybis(1,4-phenylene)diisocyanate;Benzene, 1,1'-oxybis[4-isocyanato-;Oxybis(1,4-phenylene)bisisocyanate
CBNumber:
CB2772668
Molecular Formula:
C14H8N2O3
Molecular Weight:
252.22
MDL Number:
MFCD00216648
MOL File:
4128-73-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:51:26

4,4'-Oxybis(phenyl isocyanate) Properties

Melting point 64-68 °C(lit.)
Boiling point 196 °C5 mm Hg(lit.)
Density 1.2700 (rough estimate)
refractive index 1.5910 (estimate)
solubility Acetonitrile (Soluble)
form Solid
color White to Off-White
Stability Moisture Sensitive
CAS DataBase Reference 4128-73-8
FDA UNII FY74W1G2FI
EPA Substance Registry System 4,4'-Diisocyanatodiphenyl ether (4128-73-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H312-H315-H317-H319-H330-H334-H335
Precautionary statements  P260-P280-P284-P301+P310-P305+P351+P338-P310
Hazard Codes  Xn,T+
Risk Statements  20/21/22-36/37/38-42/43-26-25-21
Safety Statements  23-26-36/37/39-45-36/37-28-22
RIDADR  UN 2206 6.1/PG 3
WGK Germany  3
TSCA  TSCA listed

4,4'-Oxybis(phenyl isocyanate) price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FO00269 4,4'-Oxybis(phenyl isocyanate) 4128-73-8 1g $154.2 2026-06-04 Buy
aablocks AA003KB6 4,4'-Bis(isocyanatophenyl)oxide 4128-73-8 100mg $184 2026-05-28 Buy
aablocks AA003KB6 4,4'-Bis(isocyanatophenyl)oxide 4128-73-8 250mg $241 2026-05-28 Buy
aablocks AA003KB6 4,4'-Bis(isocyanatophenyl)oxide 4128-73-8 500mg $316 2026-05-28 Buy
aablocks AA003KB6 4,4'-Bis(isocyanatophenyl)oxide 4128-73-8 2g $513 2026-05-28 Buy
Product number Packaging Price Buy
FO00269 1g $154.2 Buy
AA003KB6 100mg $184 Buy
AA003KB6 250mg $241 Buy
AA003KB6 500mg $316 Buy
AA003KB6 2g $513 Buy

4,4'-Oxybis(phenyl isocyanate) Chemical Properties, Uses, Production

Chemical Properties

WHITE CRYSTALLINE SOLID

Uses

4,4'-Bis(isocyanatophenyl)oxide is a reagent used in the synthesis of lipid-conjugated Smac analogs with antitumor activity against human breast cancer cell lines.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.

Reactivity Profile

Isocyanates and thioisocyanates are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.

75-44-5
101-80-4
4128-73-8
Synthesis of 4,4'-Oxybis(phenyl isocyanate) from Phosgene and 4,4'-Oxydianiline

4,4'-Oxybis(phenyl isocyanate) Preparation Products And Raw materials

Raw materials

Preparation Products

4,4'-Oxybis(phenyl isocyanate) Suppliers

Global Suppliers ( 22)
Supplier Tel Email Country ProdList Advantage
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Nanjing crow LuNing pharmaceutical technology co., LTD 13382066392 CHINA 4851 58
Shaanxi Dideu Newmaterial Co., Ltd. 029-63373950 17392216152 1035@dideu.com China 9991 58
LGC Science (Shanghai) Ltd. 17717235263 offer.de@lgcgroup.com China 19036 58
Shanghai Haohong Scientific Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 39319 58
Hangzhou Bingochem Co., Ltd. 0571-87658025 sales@bingochem.com China 21532 58
DAYANG CHEM (HANGZHOU) CO.,LTD +86-88938639 +86-17705817739 info@dycnchem.com China 53589 58
HANGZHOU LEAP CHEM CO., LTD. +86-571-87711850 +8619957148339 market18@leapchem.com China 24569 58
OXYBIS(4-PHENYL ISOCYANATE) 1,1’-oxybis[4-isocyanato-benzen 4,4'-Diisocyanato[1,1'-oxybisbenzene] 4,4'-Oxybis(isocyanatobenzene) Oxybis(1,4-phenylene)bisisocyanate Oxybis(1,4-phenylene)diisocyanate Oxybis(4-phenyl isocyanate),99% 1-isocyanato-4-(4-isocyanatophenoxy)benzene 4,4'-Bis(isocyanatophenyl)oxide Benzene, 1,1'-oxybis[4-isocyanato- 4,4'-diisocyanatodiphenyl ether 4,4'-Oxybis(phenyl isocyanate) 4128-73-8 C14H8N2O3 OC6H4NCO2 Building Blocks Organic Building Blocks Nitrogen Compounds Isocyanates Isocyanates Nitrogen Compounds Organic Building Blocks