GSK-3BETA INHIBITOR XII
- CAS No.
- 601514-19-6
- Chemical Name:
- GSK-3BETA INHIBITOR XII
- Synonyms
- TWS119;TWS11;TWS S;CS-445;CS-1924;TWS119, >=98%;TWS-119; TWS 119;OTAVA-BB 7070707013;TWS119, 10 mM in DMSO;GSK-3BETA INHIBITOR XII
- CBNumber:
- CB2803764
- Molecular Formula:
- C18H14N4O2
- Molecular Weight:
- 318.33
- MDL Number:
- MFCD09037535
- MOL File:
- 601514-19-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 249 °C |
|---|---|
| Density | 1.42 |
| storage temp. | 2-8°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO |
| pka | 8.99±0.10(Predicted) |
| form | powder |
| color | white to beige |
| InChI | 1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22) |
| InChIKey | VPVLEBIVXZSOMQ-UHFFFAOYSA-N |
| SMILES | OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
GSK-3BETA INHIBITOR XII price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1271 | TWS119 ≥98% (HPLC) | 601514-19-6 | 5MG | $129 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1271 | TWS119 ≥98% (HPLC) | 601514-19-6 | 25MG | $509 | 2026-04-30 | Buy |
| Sigma-Aldrich | 361554 | GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem | 601514-19-6 | 1mg | $190 | 2026-04-30 | Buy |
| Sigma-Aldrich | 361554 | GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem | 601514-19-6 | 5mg | $586 | 2026-04-30 | Buy |
| Cayman Chemical | 10011251 | TWS119 ≥90% | 601514-19-6 | 1mg | $41 | 2026-04-30 | Buy |
GSK-3BETA INHIBITOR XII Chemical Properties, Uses, Production
Uses
Acts as an ARMS-selective inihibitor, through GSK3 (Glucose Synthase Kinase 3) inhibition.
Uses
TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.
Definition
ChEBI: 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol is a member of pyrroles.
General Description
A cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 μM) and embryonic stem cells (D3; 50-60% at 400 nM).
Biological Activity
Inhibitor of glycogen synthase kinase-3 β (IC 50 = 30 nM). Induces neuronal differentiation in pluripotent murine embryonal carcinoma cells and embryonic stem cells (ESCs).
Biochem/physiol Actions
TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.
target
GSK-3β
storage
Store at +4°C
References
[1] ding s, wu t y h, brinker a, et al. synthetic small molecules that control stem cell fate. proceedings of the national academy of sciences, 2003, 100(13): 7632-7637.
[2] wu t y h, ding s. applying chemical tools to the discovery of novel regenerative medicine. drug discovery today: technologies, 2006, 3(3): 255-260.
GSK-3BETA INHIBITOR XII Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Jinan Trio PharmaTech Co., Ltd. | 0531-88811783 | sales@trio-pharmatech.com | China | 1856 | 62 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 | sale@labgogo.com | China | 9853 | 52 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
View Latest Price from GSK-3BETA INHIBITOR XII manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | TWS119
601514-19-6
|
$43.00-137.00 | 99.63% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | GSK-3BETA INHIBITOR XII
601514-19-6
|
$2.00 | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- TWS119
601514-19-6
- $43.00-137.00
- 99.63%
- TargetMol Chemicals Inc.
-
- GSK-3BETA INHIBITOR XII
601514-19-6
- $2.00
- 99%
- Career Henan Chemical Co
