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ChemicalBook >> CAS DataBase List >> GSK-3BETA INHIBITOR XII

GSK-3BETA INHIBITOR XII

GSK-3BETA INHIBITOR XII price.
  • $37 - $2395.3
  • Product name: GSK-3BETA INHIBITOR XII
  • CAS: 601514-19-6
  • MF: C18H14N4O2
  • MW: 318.33
  • EINECS:
  • MDL Number:MFCD09037535
  • Synonyms:GSK-3BETA INHIBITOR XII;3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL;CS-1924;TWS-119; TWS 119;CS-445;OTAVA-BB 7070707013;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119
70 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • Usbiological
Package
  • 2mg
  • 10mM*1mLinDMSO(Solution)
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 20mg
  • 10
  • 2x25mg
  • 250mg
  • 500mg
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1G
  • 10mM(in1mLDMSO)
  • Manufactureraablocks
  • Product numberAA0037E5
  • Product description3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol ≥90%
  • Packaging1mg
  • Price$41
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0037E5
  • Product description3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 95%
  • Packaging5mg
  • Price$46
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0037E5
  • Product description3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 99%
  • Packaging10mg
  • Price$47
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0037E5
  • Product description3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 99%
  • Packaging25mg
  • Price$99
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA0037E5
  • Product description3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
  • Packaging100mg
  • Price$370
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberG-7191
  • Product descriptionTWS-119 98%
  • Packaging100MG
  • Price$380
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberG-7191
  • Product descriptionTWS-119 98%
  • Packaging1G
  • Price$1350
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberG-7191
  • Product descriptionTWS-119 98%
  • Packaging25MG
  • Price$125
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberG-7191
  • Product descriptionTWS-119 98%
  • Packaging5MG
  • Price$40
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product numberX7612
  • Product descriptionTWS119
  • Packaging50mg
  • Price$309
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberKIN0000114
  • Product descriptionGSK-3B INHIBITOR (XII) 95.00%
  • Packaging5MG
  • Price$499.26
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1540
  • Product descriptionTWS119
  • Packaging50mg
  • Price$363
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1540
  • Product descriptionTWS119
  • Packaging100mg
  • Price$517
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1540
  • Product descriptionTWS119
  • Packaging10mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1540
  • Product descriptionTWS119
  • Packaging10mg
  • Price$94
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1540
  • Product descriptionTWS119
  • Packaging10mM(in1mLDMSO)
  • Price$99
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA0037E5 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol ≥90% 1mg $41 2026-05-28 Buy
aablocks AA0037E5 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 95% 5mg $46 2026-05-28 Buy
aablocks AA0037E5 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 99% 10mg $47 2026-05-28 Buy
aablocks AA0037E5 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 99% 25mg $99 2026-05-28 Buy
aablocks AA0037E5 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 100mg $370 2026-05-28 Buy
ACHEMBLOCK G-7191 TWS-119 98% 100MG $380 2026-05-27 Buy
ACHEMBLOCK G-7191 TWS-119 98% 1G $1350 2026-05-27 Buy
ACHEMBLOCK G-7191 TWS-119 98% 25MG $125 2026-05-27 Buy
ACHEMBLOCK G-7191 TWS-119 98% 5MG $40 2026-05-27 Buy
AK Scientific X7612 TWS119 50mg $309 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000114 GSK-3B INHIBITOR (XII) 95.00% 5MG $499.26 2021-12-16 Buy
ApexBio Technology B1540 TWS119 50mg $363 2026-05-06 Buy
ApexBio Technology B1540 TWS119 100mg $517 2026-05-06 Buy
ApexBio Technology B1540 TWS119 10mg $85 2021-12-16 Buy
ApexBio Technology B1540 TWS119 10mg $94 2026-05-06 Buy
ApexBio Technology B1540 TWS119 10mM(in1mLDMSO) $99 2026-05-06 Buy

Properties

Melting point :249 °C
Density :1.42
storage temp. :2-8°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
pka :8.99±0.10(Predicted)
form :powder
color :white to beige
InChI :1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChIKey :VPVLEBIVXZSOMQ-UHFFFAOYSA-N
SMILES :OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

GSK-3β Inhibitor XII, TWS119 is a cell-permeable pyrrolopyrimidine compound that has been shown to act as a potent inhibitor of GSK-3β (IC50 = 30 nM). In addition, GSK-3β Inhibitor XII, TWS119 is thought to bind GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. This activity has been shown to selectively induce neuronal differentiation in both embryonic stem cells (D3; 50-60% at 400 nM) and pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1μM). As result of GSK-3β Inhibitor XII, TWS119 T cell-specific killing and IFN-g release are reduced via preservation of IL-2 production.