GSK-3BETA INHIBITOR XII
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- $40 - $2395.3
- Product name: GSK-3BETA INHIBITOR XII
- CAS: 601514-19-6
- MF: C18H14N4O2
- MW: 318.33
- EINECS:
- MDL Number:MFCD09037535
- Synonyms:GSK-3BETA INHIBITOR XII;3-[6-(3-AMINO-PHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YLOXY]-PHENOL;CS-1924;TWS-119; TWS 119;CS-445;OTAVA-BB 7070707013;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxyphenolditrifluoroacetate;3-[[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol TWS 119
59 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Sigma-Aldrich
- Tocris
- Usbiological
Package
- 2mg
- 10mM*1mLinDMSO(Solution)
- 10mM*1mLinDMSO(Solid+Solvent)
- 20mg
- 10
- 2x25mg
- 250mg
- 500mg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 1G
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA0037E5
- Product description3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol ≥90%
- Packaging1mg
- Price$41
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037E5
- Product description3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 95%
- Packaging5mg
- Price$46
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037E5
- Product description3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 99%
- Packaging10mg
- Price$47
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037E5
- Product description3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 99%
- Packaging25mg
- Price$99
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0037E5
- Product description3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol
- Packaging100mg
- Price$370
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-7191
- Product descriptionTWS-119 98%
- Packaging100MG
- Price$380
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-7191
- Product descriptionTWS-119 98%
- Packaging1G
- Price$1350
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-7191
- Product descriptionTWS-119 98%
- Packaging25MG
- Price$125
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberG-7191
- Product descriptionTWS-119 98%
- Packaging5MG
- Price$40
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product numberX7612
- Product descriptionTWS119
- Packaging50mg
- Price$309
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000114
- Product descriptionGSK-3B INHIBITOR (XII) 95.00%
- Packaging5MG
- Price$499.26
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB1540
- Product descriptionTWS119
- Packaging100mg
- Price$517
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1540
- Product descriptionTWS119
- Packaging50mg
- Price$363
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1540
- Product descriptionTWS119
- Packaging10mM(in1mLDMSO)
- Price$99
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1540
- Product descriptionTWS119
- Packaging20mg
- Price$165
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberB1540
- Product descriptionTWS119
- Packaging10mg
- Price$94
- Updated2026-05-06
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0037E5 | 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol ≥90% | 1mg | $41 | 2026-05-28 | Buy |
| aablocks | AA0037E5 | 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 95% | 5mg | $46 | 2026-05-28 | Buy |
| aablocks | AA0037E5 | 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 99% | 10mg | $47 | 2026-05-28 | Buy |
| aablocks | AA0037E5 | 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol 99% | 25mg | $99 | 2026-05-28 | Buy |
| aablocks | AA0037E5 | 3-[[6-(3-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenol | 100mg | $370 | 2026-05-28 | Buy |
| ACHEMBLOCK | G-7191 | TWS-119 98% | 100MG | $380 | 2026-05-27 | Buy |
| ACHEMBLOCK | G-7191 | TWS-119 98% | 1G | $1350 | 2026-05-27 | Buy |
| ACHEMBLOCK | G-7191 | TWS-119 98% | 25MG | $125 | 2026-05-27 | Buy |
| ACHEMBLOCK | G-7191 | TWS-119 98% | 5MG | $40 | 2026-05-27 | Buy |
| AK Scientific | X7612 | TWS119 | 50mg | $309 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000114 | GSK-3B INHIBITOR (XII) 95.00% | 5MG | $499.26 | 2021-12-16 | Buy |
| ApexBio Technology | B1540 | TWS119 | 100mg | $517 | 2026-05-06 | Buy |
| ApexBio Technology | B1540 | TWS119 | 50mg | $363 | 2026-05-06 | Buy |
| ApexBio Technology | B1540 | TWS119 | 10mM(in1mLDMSO) | $99 | 2026-05-06 | Buy |
| ApexBio Technology | B1540 | TWS119 | 20mg | $165 | 2026-05-06 | Buy |
| ApexBio Technology | B1540 | TWS119 | 10mg | $94 | 2026-05-06 | Buy |
Properties
Melting point :249 °C
Density :1.42
storage temp. :2-8°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
pka :8.99±0.10(Predicted)
form :powder
color :white to beige
InChI :1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChIKey :VPVLEBIVXZSOMQ-UHFFFAOYSA-N
SMILES :OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
Density :1.42
storage temp. :2-8°C
solubility :insoluble in H2O; insoluble in EtOH; ≥15.9 mg/mL in DMSO
pka :8.99±0.10(Predicted)
form :powder
color :white to beige
InChI :1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
InChIKey :VPVLEBIVXZSOMQ-UHFFFAOYSA-N
SMILES :OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
GSK-3β Inhibitor XII, TWS119 is a cell-permeable pyrrolopyrimidine compound that has been shown to act as a potent inhibitor of GSK-3β (IC50 = 30 nM). In addition, GSK-3β Inhibitor XII, TWS119 is thought to bind GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. This activity has been shown to selectively induce neuronal differentiation in both embryonic stem cells (D3; 50-60% at 400 nM) and pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1μM). As result of GSK-3β Inhibitor XII, TWS119 T cell-specific killing and IFN-g release are reduced via preservation of IL-2 production.Related product price
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