2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
![2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Structure](CAS/GIF/35604-67-2.gif)
- CAS No.
- 35604-67-2
- Chemical Name:
- 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
- Synonyms
- Viloxazine HCl;Viloxazine hydrochloride;Vivalan;Vivilan;Vicilan;Catatrol;Vivarint;ICI-58834;Viloxazin Hydrochloride;Adrenaline Impurity 43-13C6
- CBNumber:
- CB2933621
- Molecular Formula:
- C13H20ClNO3
- Molecular Weight:
- 273.7558
- MDL Number:
- MFCD00661100
- MOL File:
- 35604-67-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Viloxazine hydrochloride ≥95% (HPLC) | SML3133 | 10 mg | $78.4 |
| Viloxazine hydrochloride ≥95% (HPLC) | SML3133 | 50 mg | $316 |
| Viloxazine (hydrochloride) ≥98% | 39679 | 10mg | $32 |
| Viloxazine (hydrochloride) ≥98% | 39679 | 50mg | $145 |
| Viloxazine (hydrochloride) ≥98% | 39679 | 100mg | $208 |
| More product size | |||
| Melting point | 178-180°C |
|---|---|
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| InChI | InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H |
| InChIKey | HJOCKFVCMLCPTP-UHFFFAOYSA-N |
| SMILES | C1(C=CC=CC=1OCC)OCC1OCCNC1.Cl |
| FDA UNII | OQW30I1332 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501 |
| HazardClass | IRRITANT |
| Toxicity | LD50 in mice (mg/kg): 1000 orally, 60 i.v. (Brosnan) |
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3133 | Viloxazine hydrochloride ≥95% (HPLC) | 35604-67-2 | 10 mg | $78.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3133 | Viloxazine hydrochloride ≥95% (HPLC) | 35604-67-2 | 50 mg | $316 | 2026-04-30 | Buy |
| Cayman Chemical | 39679 | Viloxazine (hydrochloride) ≥98% | 35604-67-2 | 10mg | $32 | 2026-04-30 | Buy |
| Cayman Chemical | 39679 | Viloxazine (hydrochloride) ≥98% | 35604-67-2 | 50mg | $145 | 2026-04-30 | Buy |
| Cayman Chemical | 39679 | Viloxazine (hydrochloride) ≥98% | 35604-67-2 | 100mg | $208 | 2026-04-30 | Buy |
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Originator
Vivalan,I.C.I. ,UK,1974
Uses
Rac Viloxazine Hydrochloride is research useful chemical used as an antidepressant.
Manufacturing Process
2-Ethoxyphenol is first reacted with epichlorohydrin to give 1,2-epoxy-3-(o-
ethoxyphenoxy)-propane.
A mixture of crude (83%) 1,2-epoxy-3-(o-ethoxyphenoxy)propane (19.4
grams), 70.5 grams 2-aminoethyl hydrogen sulfate, 40.0 grams sodium
hydroxide, 400 ml ethanol and 200 ml water is stirred at 60°C for 18 hours
and is then evaporated to dryness. The residue is dissolved in 200 ml water
and the mixture is extracted three times with 150 ml of diethyl ether each
time. The combined extracts are dried over magnesium sulfate and
evaporated to dryness, The crude product (21.5 grams) is dissolved in
isopropanol (20 ml), 10.5 ml concentrated aqueous hydrochloric acid and 75
ml ethyl acetate are added and the mixture is cooled. The mixture is filtered
and there is thus obtained as solid product 2-(o-ethoxyphenoxymethyl)
morpholine hydrochloride, MP 179° to 182°C (8.6 grams; 38% yield based on
total epoxide used), according to US Patent 3,712,890.
Therapeutic Function
Psychotropic
Biological Activity
Viloxazine (ICI 58,834) is an orally active serotonin norepinephrine modulating agent (SNMA) originally reported as a norepinephrine reuptake inhibitor (NRI) with antidepressant (ED10 from 0.3-1 mg/kg p.o. against reserpine-induced hypothermia in mice), while exhibiting less sedative efficacy (locomotor activity reduction ED10 from 3-10 mg/kg p.o. in mice) and no monoamine oxidase inhibitory potency. Viloxazine shows 5-HT2B antagonist and 5-HT2C agonist activity in vitro and increases extracellular 5-HT levels in the prefrontal cortex (PFC) in vivo, a brain area implicated in Attention deficit hyperactivity disorder (ADHD).
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Guangzhou Weiaokang Pharmaceutical Technology Co., Ltd | +86-13424074264 | pengguizi@cti-cert.com | China | 156 | 58 |
| Zhejiang Hengkang Pharmaceutical Co.Ltd. | +86-13858064988 | commercial@hengkangpharm.cn | China | 45 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Chongqing Soarwin Technology Co., Ltd | +86-15790943001 | crystal@sorawin.cn | China | 419 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21531 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32997 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3969 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
Related articles
- Viloxazine Hydrochloride: Synthesis and Introduction
- Viloxazine hydrochloride was synthesised using 2-ethoxyphenol as a raw material by a 4-step reaction.
- Jan 15，2024
View Lastest Price from 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride pictures](/ProductImageEN/2024-04/Small/8125d810-4a31-4f91-8acc-06fadfd4093d.gif) |
2026-08-14 | 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
35604-67-2
|
$2.00-8.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
![2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride pictures](/ProductImageEN3/2026-07/Small/5f2f8a7e-721a-47f9-924f-151cf4a5c2c8.jpg) |
2026-07-02 | 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
35604-67-2
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-08-27 | Viloxazine hydrochloride，PhEur/USP(DMF)
35604-67-2
|
1kg | 99% | 500kg | Guangzhou Weiaokang Pharmaceutical Technology Co., Ltd |
-
- 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
35604-67-2
- $2.00-8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
35604-67-2
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- Viloxazine hydrochloride，PhEur/USP(DMF)
35604-67-2
- 99%
- Guangzhou Weiaokang Pharmaceutical Technology Co., Ltd
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