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ChemicalBook >> CAS DataBase List >>(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Structure
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine structure
CAS No.
477600-70-7
Chemical Name:
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
Synonyms
7H-[4,7'-bipyrrolo[2,3-d]pyrimidin]-4'-ol;(3R,4R)-(1-benzyl-4-Methylpiperidin-3-yl)MethylaMine;Tofacitinib int;Tofacitinib Impurity 16;Tofacitinib intermediate 2;(3R,4R)-1-Benzyl-N,4-diMe...;(Cis)-Benzyl-N,4-diMethylpiperidin-3-aMine;(3R,4R)-1-BENYL-N,4-DIMETHYLPIPERIDIN-3-AMINE;(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine;CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE
CBNumber:
CB9947702
Molecular Formula:
C14H22N2
Molecular Weight:
218.34
MDL Number:
MFCD09475548
MOL File:
477600-70-7.mol
MSDS File:
SDS
Last updated:2026-05-28 05:21:04
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(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Properties

Boiling point 302.6±35.0 °C(Predicted)
Density 1.00±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
pka 10.26±0.40(Predicted)
Appearance Colorless to light yellow Liquid
InChI InChI=1S/C14H22N2/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13/h3-7,12,14-15H,8-11H2,1-2H3/t12-,14+/m1/s1
InChIKey NVKDDQBZODSEIN-OCCSQVGLSA-N
SMILES N1(CC2=CC=CC=C2)CC[C@@H](C)[C@@H](NC)C1
FDA UNII TJY7EV26LJ

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
HS Code  2933399990

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR321454 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 97% 477600-70-7 1g $21 2026-06-04 Buy
Activate Scientific AS3022-3R4R (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 97%EE 477600-70-7 1g $42 2026-06-04 Buy
Apolloscientific OR321454 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 97% 477600-70-7 5g $60 2026-06-04 Buy
Activate Scientific AS3022-3R4R (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 97%EE 477600-70-7 5g $84 2026-06-04 Buy
Apolloscientific OR321454 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 97% 477600-70-7 25g $192 2026-06-04 Buy
Product number Packaging Price Buy
OR321454 1g $21 Buy
AS3022-3R4R 1g $42 Buy
OR321454 5g $60 Buy
AS3022-3R4R 5g $84 Buy
OR321454 25g $192 Buy

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Chemical Properties,Uses,Production

Uses

(3R,4R)-N,4-Dimethyl-1-benzyl-3-piperidinamine (D464895) is a reagent used in the preparation of Janus tyrosine kinase inhibitors for the treatment of autoimmune diseases.

Synthesis

Pyridinium, 4-methyl-3-(methylamino)-1-(phenylmethyl)-, bromide (1:1)

1615709-89-1

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine

477600-70-7

The general procedure for the synthesis of (3R,4R)-1-benzyl-4-methyl-3-(methylamino)pyridin-1-ium bromide as a raw material for the synthesis of (3R,4R)-1-benzyl-4-methyl-3-methylamino-piperidines was as follows: 1-benzyl-3-methylamino-4-methyl-pyridinium bromide (10 g, 34.1 mmol) was placed in a 250 ml reaction flask, ethanol (100 g) was added, and a temperature of below 30°C and stirring was started. Sodium borohydride (3.87 g, 102.3 mmol) was added slowly and after addition, the reaction was continued with stirring for 16 h. The reaction was monitored by HPLC until the content of raw material was below 1%. Subsequently, 2M HCl solution was slowly added dropwise to the reaction system until no bubbles were generated. The reaction solution was concentrated to one third of the original volume under reduced pressure. It was extracted twice with dichloromethane, the organic phases were combined and concentrated under reduced pressure to remove the solvent. To the resulting crude product, ethanol (40 g) was added and 2M hydrochloric acid ethanol solution (20 ml) was slowly added dropwise at a temperature below 30 °C. A solid precipitated. After dropwise addition, stirring was continued for 1 h. Subsequently, filtration was carried out and the filter cake was dried under reduced pressure. The final white solid product (3R,4R)-1-benzyl-4-methyl-3-methylamino-piperidine (6.9 g, 23.8 mmol) was obtained in 70% yield.

References

[1] Patent: CN108610279, 2018, A. Location in patent: Paragraph 0014; 0016

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine synthesis

1615709-89-1
477600-70-7
Synthesis of (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine from Pyridinium, 4-methyl-3-(methylamino)-1-(phenylmethyl)-, bromide (1:1)

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Preparation Products And Raw materials

Raw materials

Pyridinium, 4-methyl-3-(methylamino)-1-(phenylmethyl)-, bromide (1:1) 1-benzyl-3-((Methoxycarbonyl)aMino)-4-Methylpyridin-1-iuM broMide Methanamine Acetate 1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE 1-benzyl-4-methylpiperidin-3-one
(1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester

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Preparation Products

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Suppliers

Global( 220)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Boc Chemical Co.,Ltd 021-34975603-808 18721111801 sales@bocpharma.com China 991 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
T&W GROUP 021-61551611 13296011611 contact@trustwe.com China 9884 58
Shanghai Coupling Pharmaceutical R&D Co.,Ltd.（Former company is Brother Chemistry） 021-50106671 China 49 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
Shanghai Boc Chemical Co.,Ltd 64
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Nanjing Vital Chemical Co., Ltd. 65
T&W GROUP 58
Shanghai Coupling Pharmaceutical R&D Co.,Ltd.（Former company is Brother Chemistry） 58

View Lastest Price from (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine pictures 2026-09-02 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
477600-70-7
 $5.00 1KG 99% Henan Fengda Chemical Co., Ltd
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine pictures 2026-08-20 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
477600-70-7
 $1.10 1g 99.0% Min 100 Tons Dideu Industries Group Limited
(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine pictures 2026-08-08 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine
477600-70-7
 1KG 98% 200 Hangzhou ICH Biofarm Co., Ltd

477600-70-7((3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine)Related Search:

Chloropretadalafil cis-Octahydroisoindole Tetrahydro-5-oxo-2- furancarboxyli (2S,4S)-4-METHOXY-PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER (+)-(3R,4R)-3,4-DIMETHYL-4-(3-HYDROXYPHENYL)PIPERIDINE
cis-tert-butyl 4-fluoro-3-hydroxypiperidine-1-carboxylate cis-3-azabicyclo[3,3,0]oct-2-ene (1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester Tofacitinib Impurity 6 (3R,4R)-3-[(6-amino-4-pyrimidinyl)methylamino]-4-methyl-β-oxo-1-Piperidinepropanenitrile
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2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 3-bis(4-Methylbenzoyloxy)succinate) 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-

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(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine (Cis)-Benzyl-N,4-diMethylpiperidin-3-aMine (3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine hydrochloride 3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, (3R,4R)- (3R,4R)-1-Benzyl-N,4-diMe... (3R,4R)-1-Benzyl-N-Methyl-4-Methylpiperidin-3-aMine (3R,4R)-1-BENYL-N,4-DIMETHYLPIPERIDIN-3-AMINE (3R,4R)-N,4-DiMethyl-1-benzyl-3-piperidinaMine CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE (3R,4R)-1-Benzyl-N-methyl-4-methylpiperdin-3-amine Tofacitinib int-1 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine Tofacitinib intermediate 2 Tofacitinib Impurity 16 Cis-1-benzyl-4-methyl-3-methylamino-piperidine Tofacitinib int (3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine ISO 9001：2015 REACH (3R,4R)-(1-benzyl-4-Methylpiperidin-3-yl)MethylaMine 7H-[4,7'-bipyrrolo[2,3-d]pyrimidin]-4'-ol 477600-70-7