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R(+)-SKF-81297 hydrobromide selective d1 dopamine

R(+)-SKF-81297 hydrobromide selective d1 dopamine structure

CAS No.: 253446-15-0

Chemical Name:: R(+)-SKF-81297 hydrobromide selective d1 dopamine

Synonyms: R(+)-SKF-81297;R(+)-SKF-81297 hydrobromide selective d1 dopamine;(5R)-9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol

CBNumber:: CB2972828

Molecular Formula:: C16H16ClNO2.BrH

Molecular Weight:: 370.672

MDL Number:: MFCD00671792

MOL File:: 253446-15-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:51:31

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R(+)-SKF-81297 hydrobromide selective d1 dopamine Properties

solubility	H2O: soluble6mg/mL
form	solid
color	white to off-white
optical activity	[α]22/D +15.14°, c = 0.52 in DMF(lit.)
Water Solubility	H2O: 6mg/mL DMSO: soluble
InChI	1S/C16H16ClNO2.BrH/c17-15-11-6-7-18-9-13(10-4-2-1-3-5-10)12(11)8-14(19)16(15)20;/h1-5,8,13,18-20H,6-7,9H2;1H/t13-;/m1./s1
InChIKey	RMIJGBMRNYUZRG-BTQNPOSSSA-N
SMILES	Br[H].Oc1cc2[C@H](CNCCc2c(Cl)c1O)c3ccccc3
FDA UNII	J494DH8JRC
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
Storage Class	11 - Combustible Solids

R(+)-SKF-81297 hydrobromide selective d1 dopamine price More Price(9)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	S179	R(+)-SKF-81297 hydrobromide ≥98% (HPLC), solid	253446-15-0	5mg	$863	2026-04-30	Buy
Biosynth	BS162625	R(+)-SKF-81297 hydrobromide	253446-15-0	1mg	$649	2026-06-04	Buy
Biosynth	BS162625	R(+)-SKF-81297 hydrobromide	253446-15-0	2mg	$1038.4	2026-06-04	Buy
Biosynth	BS162625	R(+)-SKF-81297 hydrobromide	253446-15-0	5mg	$1622.5	2026-06-04	Buy
Biosynth	BS162625	R(+)-SKF-81297 hydrobromide	253446-15-0	10mg	$2855.6	2026-06-04	Buy

Product number	Packaging	Price	Buy
S179	5mg	$863	Buy
BS162625	1mg	$649	Buy
BS162625	2mg	$1038.4	Buy
BS162625	5mg	$1622.5	Buy
BS162625	10mg	$2855.6	Buy

R(+)-SKF-81297 hydrobromide selective d1 dopamine Chemical Properties, Uses, Production

Uses

R(+)-SKF-81297 Hydrobromide is a dopamine D1 agonist.

Uses

R(+)-SKF-81297 hydrobromide has used as D1-type dopamine receptor agonist:

to test it effect on the spike firing in rat retinal ganglion cells
in human embryonic kidney (HEK) 293T cells
to test its inhibitory effect in microglial cells

Biochem/physiol Actions

SKF-81297 administration in spontaneously hypertensive rats (SHR) induces an increase in expression of proto-oncogene c-fos mRNA leading to biphasic effect on locomotion. It favors the turnover of phosphoinositide and adenylyl cyclase. SKF-81297 is involved in the stimulation of neurons, in particular the postsynaptic striatal neurons.

R(+)-SKF-81297 hydrobromide selective d1 dopamine Preparation Products And Raw materials

Raw materials

Preparation Products

R(+)-SKF-81297 hydrobromide selective d1 dopamine Suppliers

Global Suppliers ( 12)

Supplier	Tel	Email	Country	ProdList	Advantage
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai Anhua Biotechnology Co., Ltd.	021-61263375 18168859245		China	5955	58
Wuxi maimo topp biotechnology co., LTD	15861600115	lisa-li@mimotopes.cn	China	5795	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29874	58

Supplier	Advantage
Sigma-Aldrich	80
Shanghai Anhua Biotechnology Co., Ltd.	58
Wuxi maimo topp biotechnology co., LTD	58
TargetMol Chemicals Inc.	58

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R(+)-SKF-81297 (5R)-9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol R(+)-SKF-81297 hydrobromide selective d1 dopamine 253446-15-0