Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- Structure
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- structure
CAS No.
2226303-74-6
Chemical Name:
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-
Synonyms
Thalidomide-5-propargyl;Thalidomide-5-O-propargyl;2-(2,6-dioxopiperidin-3-yl)-5-(prop-2-yn-1-yloxy)isoindoline-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-
CBNumber:
CB29806740
Molecular Formula:
C16H12N2O5
Molecular Weight:
312.28
MDL Number:
MOL File:
2226303-74-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 00:53:38
Request For Quotation

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- Properties

Boiling point 587.6±50.0 °C(Predicted)
Density 1.469±0.06 g/cm3(Predicted)
storage temp. 2-8°C, stored under nitrogen
form Solid
pka 10.70±0.40(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0567223 Thalidomide-5-propargyl ≥95% 2226303-74-6 50mg $67 2026-06-04 Buy
ChemScene CS-0567223 Thalidomide-5-propargyl ≥95% 2226303-74-6 100mg $112 2026-06-04 Buy
BroadPharm bp-40517 Thalidomide-5'-O-propargyl 2226303-74-6 100MG $350 2026-05-24 Buy
BroadPharm bp-40517 Thalidomide-5'-O-propargyl 2226303-74-6 250MG $650 2026-05-24 Buy
BroadPharm bp-40517 Thalidomide-5'-O-propargyl 2226303-74-6 500MG $1100 2026-05-24 Buy
Product number Packaging Price Buy
CS-0567223 50mg $67 Buy
CS-0567223 100mg $112 Buy
bp-40517 100MG $350 Buy
bp-40517 250MG $650 Buy
bp-40517 500MG $1100 Buy

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- Chemical Properties, Uses, Production

Uses

Thalidomide-5-propargyl is a propargyl-modified Thalidomide (HY-14658), that acts as a Cereblon ligand to recruit CRBN proteins. Thalidomide-5-propargyl use alkynyl group at the end to be directly used in the synthesis of triazoles in the synthesis of PROTAC molecules, and is a key intermediate in the synthesis of PROTAC molecules based on CRBN design[1].

IC 50

Cereblon

References

[1] Crew, et al. Preparation of tau-protein targeting bifunctional compounds (PROTACS) as E3 ubiquitin ligase binding useful in treatment and prevention of diseases. United States, US20180125821 A1. 2018-05-10.

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- Preparation Products And Raw materials

Raw materials

Preparation Products

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- Suppliers

Global Suppliers ( 27)
Supplier Tel Email Country ProdList Advantage
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7917 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
BioPharmaMatrix,Inc. 0510-86010668 13395169561; sales@biopharmamatrix.com China 5018 55
SuZhou Medinoah Co.,LTD. 0512-69561983 13914027025 zhang_q@medinoah.com China 3925 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
CR Corporation Limited fred.wen@crcorporation.cn China 8642 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 025-86755008 17751752005 hszhang@bestfluorodrug.com China 2357 58
Taizhou Nanfeng Pharmaceutical Research Institute nanfengpharma@126.co 18616377689 nanfengpharma@126.com China 20008 58
Shanghai Haohong Pharmaceutical Co., Ltd. 400-8210725 4008210725 malulu@leyan.com China 54996 58
Zhejiang Huida Biotech Co., LTD 0571-89903022 18679456698 zilong@hizyme.com China 8001 58
Supplier Advantage
Daicel Chiral Technologies (China)CO.,LTD 65
Shanghai EFE Biological Technology Co., Ltd. 58
BioPharmaMatrix,Inc. 55
SuZhou Medinoah Co.,LTD. 58
Jilin Province Woda Biotechnology Co., Ltd. 58
CR Corporation Limited 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 58
Taizhou Nanfeng Pharmaceutical Research Institute 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
Zhejiang Huida Biotech Co., LTD 58

View Latest Price from 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- pictures 2026-06-30 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-
2226303-74-6
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- Spectrum

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-(2226303-74-6)1HNMR1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-(2226303-74-6)13CNMR

2226303-74-6 (1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-) Related Search:

Doxorubicin hydrochloride MonoMethyl auristatin E ANGIOTENSIN II, HUMAN Metformin Oxaliplatin
LY 294002 Hydrochloride

1of2

1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)- 2-(2,6-dioxopiperidin-3-yl)-5-(prop-2-yn-1-yloxy)isoindoline-1,3-dione Thalidomide-5-propargyl Thalidomide-5-O-propargyl 2-(2,6-Dioxo-3-piperidinyl)-5-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione 2226303-74-6