CARDAMONIN
- CAS No.
- 19309-14-9
- Chemical Name:
- CARDAMONIN
- Synonyms
- (8CI);Cardamomin-RM;CARDAMONIN(RG);(E)-Cardamonin;Cardamonin, >=98%;Alpinetin chalcone;6-Diaminocaproic acid;CAS19309-14-9 CARDAMONIN;(E)-Cardamonin, 10 mM in DMSO;(E)-Cardamonin ((E)-Cardamomin)
- CBNumber:
- CB31092214
- Molecular Formula:
- C16H14O4
- Molecular Weight:
- 270.28
- MDL Number:
- MFCD00238554
- MOL File:
- 19309-14-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Cardamonin ≥98% (HPLC) | C8249 | 5mg | $164.35 |
| Wnt/β-catenin Inhibitor, Cardamonin | 681672 | 2mg | $150 |
| Cardamonin ≥98% | 18310 | 5mg | $59 |
| Cardamonin ≥98% | 18310 | 10mg | $112 |
| Cardamomin phyproof Reference Substance | PHL80379 | 10mg | $353 |
| More product size | |||
| Melting point | 199～200℃ |
|---|---|
| Boiling point | 484.5±45.0 °C(Predicted) |
| Density | 1.282±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: ≥20mg/mL |
| form | powder |
| pka | 7.00±0.40(Predicted) |
| color | yellow |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 weeks. |
| InChI | InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+ |
| InChIKey | NYSZJNUIVUBQMM-BQYQJAHWSA-N |
| SMILES | C(C1=C(OC)C=C(O)C=C1O)(=O)/C=C/C1=CC=CC=C1 |
| FDA UNII | H8KP1OJ8JX |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
CARDAMONIN price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C8249 | Cardamonin ≥98% (HPLC) | 19309-14-9 | 5mg | $164.35 | 2025-07-31 | Buy |
| Sigma-Aldrich | 681672 | Wnt/β-catenin Inhibitor, Cardamonin | 19309-14-9 | 2mg | $150 | 2025-07-31 | Buy |
| Cayman Chemical | 18310 | Cardamonin ≥98% | 19309-14-9 | 5mg | $59 | 2024-03-01 | Buy |
| Cayman Chemical | 18310 | Cardamonin ≥98% | 19309-14-9 | 10mg | $112 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL80379 | Cardamomin phyproof Reference Substance | 19309-14-9 | 10mg | $353 | 2025-07-31 | Buy |
CARDAMONIN Chemical Properties,Uses,Production
Description
Cardamonin (19309-14-9) inhibits NF-κB activation via inhibition of IκBα degradation and phosphorylation, IκB kinase activation and NF-κB nuclear translocation.1,2 Cardamonin displays anti-inflammatory activity in various models.3?Cell permeable.
Uses
Cardamonin has been used as a glycogen synthase kinase 3 (GSK3) inhibitor to study its effects on β-catenin loss and gain-of-function in human preimplantation embryos.
Definition
ChEBI: Cardamonin is a member of chalcones.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
Chalone analog that display anti-inflammatory activity. Inhibits NO and PGE 2 production from LPS- and IFN- γ -induced RAW cells and inhibits TXB 2 production via the COX-1 and COX-2 pathways. Inhibits NF- κ B activation via inhibition of I κ B α degradation and phosphorylation, I κ B kinase activation and NF- κ B nuclear translocation.
Biochem/physiol Actions
Cardamonin is a calchone from Aplinia species (zingiberaceous plant species). Cardamonin inhibits pigmentation in melanocytes through suppression of Wnt/b-catenin signaling pathway. Cardamonin suppressed Wnt/b-catenin signaling by a mechanism involving proteasome-mediated degradation of b-catenin (GSK-3b-independent pathway). Research has shown that Cardamonin possesses anti-inflammatory activity via suppression of NF-kB nuclear translocation and Ik-Ba phosphorylation.
storage
Store at +4°C
References
[1] JEONG-HYUNG LEE. Blockade of nuclear factor-kappaB signaling pathway and anti-inflammatory activity of cardamomin, a chalcone analog from Alpinia conchigera.[J]. Journal of Pharmacology and Experimental Therapeutics, 2006, 316 1: 271-278. DOI:10.1124/jpet.105.092486
[2] D.A. ISRAF . Cardamonin inhibits COX and iNOS expression via inhibition of p65NF-κB nuclear translocation and Iκ-B phosphorylation in RAW 264.7 macrophage cells[J]. Molecular immunology, 2007, 44 5: Pages 673-679. DOI:10.1016/j.molimm.2006.04.025
[3] SYAHIDA AHMAD . Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood[J]. European journal of pharmacology, 2006, 538 1: Pages 188-194. DOI:10.1016/j.ejphar.2006.03.070
CARDAMONIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21620 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29852 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | 52513593@qq.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
View Lastest Price from CARDAMONIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-17 | (E)-Cardamonin
19309-14-9
|
US $30.00-79.00 / mg | 99.07% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Cardamonin
19309-14-9
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2023-02-24 | Cardamonin
19309-14-9
|
US $0.00 / mg | 5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- (E)-Cardamonin
19309-14-9
- US $30.00-79.00 / mg
- 99.07%
- TargetMol Chemicals Inc.
-
- Cardamonin
19309-14-9
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Cardamonin
19309-14-9
- US $0.00 / mg
- Analytical Standard
- Shanghai Standard Technology Co., Ltd.
