MOLLUGIN
- CAS No.
- 55481-88-4
- Chemical Name:
- MOLLUGIN
- Synonyms
- Rubimaillin;MOLLUGIN;Mollugin-RM;MOLLUGIN(SH);Mollugin (Standard);Mollugin/rubiMaillin;RUBIMAILLIN; MOLLUGIN;6-hydroxy-2, 2-dimethyl-, methylester;Mollugin, 98%, from Rubia cordifolia L.;2H-Naphtho[1,2-b]pyran-5-carboxylic acid
- CBNumber:
- CB4279530
- Molecular Formula:
- C17H16O4
- Molecular Weight:
- 284.31
- MDL Number:
- MFCD02752331
- MOL File:
- 55481-88-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 132~134℃ |
|---|---|
| Boiling point | 453.2±45.0 °C(Predicted) |
| Density | 1.239±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| pka | 8.40±0.40(Predicted) |
| form | Solid |
| color | Yellow to Green |
| Major Application |
metabolomics vitamins, nutraceuticals, and natural products |
| InChI | InChI=1S/C17H16O4/c1-17(2)9-8-12-13(16(19)20-3)14(18)10-6-4-5-7-11(10)15(12)21-17/h4-9,18H,1-3H3 |
| InChIKey | VLGATXOTCNBWIT-UHFFFAOYSA-N |
| SMILES | C12=C3C(C=CC=C3)=C(O)C(C(OC)=O)=C1C=CC(C)(C)O2 |
| FDA UNII | M98N6A8Z2F |
| UNSPSC Code | 41116107 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29329990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
MOLLUGIN price More Price(81)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL80499 | Mollugin phyproof? Reference Substance | 55481-88-4 | 10MG | $457 | 2026-04-30 | Buy |
| Sigma-Aldrich | SMB00431 | Mollugin ≥98% (HPLC) | 55481-88-4 | 1MG | $137 | 2023-06-20 | Buy |
| Sigma-Aldrich | SMB00431 | Mollugin ≥98% (HPLC) | 55481-88-4 | 5MG | $340 | 2023-06-20 | Buy |
| TCI Chemical | M3091 | Mollugin >98.0%(HPLC) | 55481-88-4 | 10mg | $62 | 2026-04-30 | Buy |
| TCI Chemical | M3091 | Mollugin >98.0%(HPLC) | 55481-88-4 | 50mg | $186 | 2026-04-30 | Buy |
MOLLUGIN Chemical Properties, Uses, Production
Chemical Properties
Derived from the dried root of Rubia cordifolia L.
Uses
Mollugin is an anti-tumor agent inducing apoptosis and autophagy in various cancer models.
Definition
ChEBI: Rubimaillin is a benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-alpha-induced NF-kappaB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme. It has a role as a plant metabolite, an acyl-CoA:cholesterol acyltransferase 2 inhibitor, a NF-kappaB inhibitor, an antineoplastic agent, an apoptosis inducer, a neuroprotective agent and an anti-inflammatory agent. It is a benzochromene, a methyl ester and a member of phenols.
Biological Activity
Mollugin displays inhibitory activity in arachidonic acid- and collagen-induced platelet aggregation. Mollugin has been reported to inhibit cancer cell proliferation, and has other biological activities including anti-inflammatory and apoptotic effects.
in vivo
Mollugin (0-75 mg/kg, Orally, three times per week for 36 days) inhibits growth of HeLa cells in a xenograft tumor model[1].
| Animal Model: | BALB/c female athymic nude mice (six-week-old, subcutaneously injected with 0.2 mL HeLa cells)[1] |
| Dosage: | 0, 25 and 75 mg/kg |
| Administration: | Orally, three times per week for 36 days |
| Result: | Suppressed tumor growth, whereas the body weight did not change. Significantly reduced the protein expression of p-p65 and COX-2 in the tumors. |
MOLLUGIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Jianchuang Biotechnology Co., Ltd. | 13335389838 | 3305337057@qq.com | China | 220 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Chengdu Climax Biotech Co., Ltd. | 028-83311324 1278112614 | climaxbiotech@gmail.com | China | 925 | 58 |
| Shanghai Winherb Medical Technology Co., Ltd. | 17301719108 13341702378 | winherb@126.com | China | 1245 | 58 |
View Latest Price from MOLLUGIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Mollugin
55481-88-4
|
$39.00-128.00 | 99.87% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Mollugin
55481-88-4
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2023-02-24 | Mollugin
55481-88-4
|
5mg | Analytical Standard | 10 g | Shanghai Standard Technology Co., Ltd. |
