methyl indoline-5-carboxylate
- CAS No.
- 141452-01-9
- Chemical Name:
- methyl indoline-5-carboxylate
- Synonyms
- methyl indoline-5-carboxylate;Methyl 2,3-dihydro-1H-indole-5-carboxylate;2,3-Dihydro-1H-indol-5-carboxylic acid methyl ester;1H-Indole-5-carboxylicacid, 2,3-dihydro-, methyl ester
- CBNumber:
- CB31094203
- Molecular Formula:
- C10H11NO2
- Molecular Weight:
- 177.2
- MDL Number:
- MFCD07371630
- MOL File:
- 141452-01-9.mol
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 5-Methoxycarbonyl-2,3-dihydro-1H-indole Asreported | 284086 | 250mg | $382 |
| 5-Methoxycarbonyl-2,3-dihydro-1H-indole Asreported | 284086 | 500mg | $531 |
| 5-Methoxycarbonyl-2,3-dihydro-1H-indole Asreported | 284086 | 1g | $958 |
| 5-Methoxycarbonyl-2,3-dihydro-1H-indole Asreported | 284086 | 2g | $1371 |
| 5-Methoxycarbonyl-2,3-dihydro-1H-indole Asreported | 284086 | 5g | $1988 |
| More product size | |||
| Melting point | 67-69 °C |
|---|---|
| Boiling point | 331.0±31.0 °C(Predicted) |
| Density | 1.162±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | 2.65±0.20(Predicted) |
| color | Off-White |
| InChI | InChI=1S/C10H11NO2/c1-13-10(12)8-2-3-9-7(6-8)4-5-11-9/h2-3,6,11H,4-5H2,1H3 |
| InChIKey | VVAPQJBMJBCZMH-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=C(C(OC)=O)C=C2)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H312-H332 |
| Precautionary statements | P280 |
| HS Code | 2933998090 |
methyl indoline-5-carboxylate price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 284086 | 5-Methoxycarbonyl-2,3-dihydro-1H-indole Asreported | 141452-01-9 | 250mg | $382 | 2026-06-03 | Buy |
| Usbiological | 284086 | 5-Methoxycarbonyl-2,3-dihydro-1H-indole Asreported | 141452-01-9 | 500mg | $531 | 2026-06-03 | Buy |
| Usbiological | 284086 | 5-Methoxycarbonyl-2,3-dihydro-1H-indole Asreported | 141452-01-9 | 1g | $958 | 2026-06-03 | Buy |
| Usbiological | 284086 | 5-Methoxycarbonyl-2,3-dihydro-1H-indole Asreported | 141452-01-9 | 2g | $1371 | 2026-06-03 | Buy |
| Usbiological | 284086 | 5-Methoxycarbonyl-2,3-dihydro-1H-indole Asreported | 141452-01-9 | 5g | $1988 | 2026-06-03 | Buy |
methyl indoline-5-carboxylate Chemical Properties,Uses,Production
Synthesis
1011-65-0
141452-01-9
The general procedure for the synthesis of indoline-5-carboxylic acid methyl ester from indole-5-carboxylic acid was as follows: to a 10 mL solution of 1H-indole-5-carboxylic acid methyl ester (1 g, 5.71 mmol) in acetic acid was slowly added sodium cyano-borohydride (1.08 g, 17.18 mmol) at 0 °C, with the addition time being controlled to be within 5 minutes. The reaction mixture was stirred at room temperature for 1 hour. Upon completion of the reaction, water (3 mL) was added and all solvent was evaporated under reduced pressure. The residue was dissolved in ethyl acetate (150 mL) and saturated sodium bicarbonate solution (150 mL) for liquid-liquid separation. The aqueous phase was further extracted with ethyl acetate (3 x 75 mL). All organic phases were combined, washed with saturated saline (150 mL), dried over anhydrous sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The crude product was purified by fast column chromatography (eluent: 0-50% hexane solution of ethyl acetate containing 0.1% triethylamine) to afford the target product methyl indoline-5-carboxylate (0.99 g, 99% yield).
References
[1] Patent: WO2010/149685, 2010, A1. Location in patent: Page/Page column 51
[2] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 20, p. 5684 - 5688
[3] Patent: US2015/368195, 2015, A1. Location in patent: Paragraph 0072
[4] Organic and Biomolecular Chemistry, 2014, vol. 12, # 44, p. 8966 - 8976
[5] Journal of Medicinal Chemistry, 2006, vol. 49, # 14, p. 4425 - 4436
methyl indoline-5-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63645 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21135 | 58 |
| Blocksynth Pharmaceutical Technology Co.,Ltd | 0086-19817745290; 19817745290 | bd@blocksynth.com | China | 5971 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52693 | 58 |
| Labnetwork lnc. | +86-27-50766799 +86-18062016861 | contact@labnetwork.com | China | 19981 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +86-18949823763 | sales@tnjchem.com | China | 25333 | 58 |
| Taizhou Blazer Biomedical Technology Co., Ltd. | 0523-86112008 13915404123 | sales@blazerbio.com | China | 88 | 58 |
View Lastest Price from methyl indoline-5-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-06-02 | Methyl-indole-5-carboxylate in stock Factory
141452-01-9
|
$1.00 | 1KG | TOP 3 Factory in China | Chemwill Asia Co.,Ltd. | ||
 |
2019-07-06 | methyl indoline-5-carboxylate
141452-01-9
|
$8.00 | 1kg | 99% | 10tons | Career Henan Chemical Co |
-
- Methyl-indole-5-carboxylate in stock Factory
141452-01-9
- $1.00
- TOP 3 Factory in China
- Chemwill Asia Co.,Ltd.
-
- methyl indoline-5-carboxylate
141452-01-9
- $8.00
- 99%
- Career Henan Chemical Co
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