Indole-4-boronic acid
- CAS No.
- 220465-43-0
- Chemical Name:
- Indole-4-boronic acid
- Synonyms
- 4-BORONOINDOLE;1H-INDOL-4-YLBORONIC ACID;AKOS BRN-0119;Indole-4-Boronic;4-Borono-1H-indole;4-INDOLEBORONIC ACID;ndole-4-boronic acid;INDOLE-4-BORONIC ACID;4-INDOLYLBORONIC ACID;1H-indol-4-ylboronicaci
- CBNumber:
- CB5704374
- Molecular Formula:
- C8H8BNO2
- Molecular Weight:
- 160.97
- MDL Number:
- MFCD03095175
- MOL File:
- 220465-43-0.mol
- MSDS File:
- SDS
| Boiling point | 433.2±37.0 °C(Predicted) |
|---|---|
| Density | 1.33 |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| pka | 9.00±0.30(Predicted) |
| form | solid |
| color | Grey |
| Sensitive | Air Sensitive |
| InChI | 1S/C8H8BNO2/c11-9(12)7-2-1-3-8-6(7)4-5-10-8/h1-5,10-12H |
| InChIKey | USJUQEVUEBCLLR-UHFFFAOYSA-N |
| SMILES | OB(O)c1cccc2[nH]ccc12 |
| CAS DataBase Reference | 220465-43-0(CAS DataBase Reference) |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41-36/37/38 | |||||||||
| Safety Statements | 26-39-36/37/39 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| TSCA | N | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Indole-4-boronic acid price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 280425 | Indole-4-boronic acid | 220465-43-0 | 100mg | $406 | 2026-06-03 | Buy |
| Usbiological | 280425 | Indole-4-boronic acid | 220465-43-0 | 250mg | $605 | 2026-06-03 | Buy |
| Usbiological | 280425 | Indole-4-boronic acid | 220465-43-0 | 500mg | $914 | 2026-06-03 | Buy |
| Usbiological | 280425 | Indole-4-boronic acid | 220465-43-0 | 1g | $1413 | 2026-06-03 | Buy |
| Usbiological | 280425 | Indole-4-boronic acid | 220465-43-0 | 2g | $2262 | 2026-06-03 | Buy |
Indole-4-boronic acid Chemical Properties, Uses, Production
Chemical Properties
Light yellow to grey powder
Uses
An arylboronic acid-based fluorescent biosensor.
Synthesis
52488-36-5
220465-43-0
The general procedure for the synthesis of 4-indoleboronic acid from 4-bromoindole was as follows: a mixture of potassium hydride (35% w/w, dispersed in mineral oil, 4.5 g, 39.3 mmol) and ether (105 mL) was added to a round-bottomed flask at 0 °C, followed by the slow addition of a solution of 4-bromo-1H-indole (7.0 g, 35.7 mmol) in ether (35 mL). The reaction mixture was transferred to a cold bath at -78 °C with continuous stirring for 45 min. A solution of tert-butyllithium (1.7 M in pentane, 46.2 mL, 78.5 mmol) pre-cooled to -78 °C was added to the reaction system via cannula. At -78 °C, tributyl borate (29 mL, 107.1 mmol) was added to the reaction slurry. The reaction system was gradually warmed to room temperature for 21 hours. Subsequently, the reaction mixture was placed in a 0 °C bath and phosphoric acid solution (350 mL, 1 M) was added. The mixture was stirred for 30 min and then extracted with ether, the organic phase was dried with anhydrous sodium sulfate and concentrated in vacuum to afford the target product 4-indoleboronic acid (4.01 g, 70% yield) as a beige solid. The product was characterized by 1H NMR ((CD3)2CO/15% D2O, 400 MHz) and mass spectrometry (MS).
References
[1] Journal of Organic Chemistry, 1999, vol. 64, # 4, p. 1372 - 1374
[2] Organic Letters, 2004, vol. 6, # 1, p. 3 - 5
[3] Patent: WO2009/73777, 2009, A1. Location in patent: Page/Page column 195-196
Indole-4-boronic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Indole-4-boronic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from Indole-4-boronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2022-01-27 | Indole-4-boronic acid
220465-43-0
|
1KG | 97.2% | 100 tons | Honest Joy Holdings Limited | ||
 |
2019-12-23 | Indole-4-boronic acid
220465-43-0
|
1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. | ||
 |
2019-12-23 | Indole-4-boronic acid
220465-43-0
|
1g | 95%min | 20kg/month | Nanjing jinheyou Trading Co., Ltd. |
-
- Indole-4-boronic acid
220465-43-0
- $0.00
- 97.2%
- Honest Joy Holdings Limited
-
- Indole-4-boronic acid
220465-43-0
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
-
- Indole-4-boronic acid
220465-43-0
- $0.00
- 95%min
- Nanjing jinheyou Trading Co., Ltd.
