1H-Indole-3-aceticacid,4-bromo-(9CI)
- CAS No.
- 89245-41-0
- Chemical Name:
- 1H-Indole-3-aceticacid,4-bromo-(9CI)
- Synonyms
- 2-(4-bromo-1H-indol-3-yl)acetic acid;4-Bromoindole-3-acetic Acid;4-Bromo-3-indoleacetic acid;4-broMo-1H-indole-3-acetic acid;1H-Indole-3-acetic acid, 4-broMo-;(4-Bromo-1H-indol-3-yl)-acetic acid;1H-Indole-3-aceticacid,4-bromo-(9CI)
- CBNumber:
- CB31297828
- Molecular Formula:
- C10H8BrNO2
- Molecular Weight:
- 254.08
- MDL Number:
- MFCD09751717
- MOL File:
- 89245-41-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
1H-Indole-3-aceticacid,4-bromo-(9CI) price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Matrix Scientific | 075814 | 2-(4-Bromo-1H-indol-3-yl)acetic acid | 89245-41-0 | 1.00g | $98 | 2026-05-18 | Buy |
| Matrix Scientific | 075814 | 2-(4-Bromo-1H-indol-3-yl)acetic acid | 89245-41-0 | 5.00g | $333 | 2026-05-18 | Buy |
| Matrix Scientific | 075814 | 2-(4-Bromo-1H-indol-3-yl)acetic acid | 89245-41-0 | 25.00g | $1285 | 2026-05-18 | Buy |
| aablocks | AA0042FY | 2-(4-bromo-1H-indol-3-yl)acetic acid 98% | 89245-41-0 | 100mg | $32 | 2026-05-28 | Buy |
| aablocks | AA0042FY | 2-(4-bromo-1H-indol-3-yl)acetic acid 98% | 89245-41-0 | 250mg | $38 | 2026-05-28 | Buy |
1H-Indole-3-aceticacid,4-bromo-(9CI) Chemical Properties,Uses,Production
Synthesis
65018-18-0
89245-41-0
To a dry three-necked flask was added 98.0 kg of 4-bromoindole, 307.0 kg of aluminum trichloride and 500 L of methylene chloride, and 79.0 kg of acetyl chloride was added slowly and dropwise to the three-necked flask. The reaction mixture was heated to 40 °C and kept for 8 hours. Upon completion of the reaction, the mixture was poured into 800 L of ice water, the organic phase was separated and the solvent was recovered to give 1,3-diacetyl-4-bromoindole. Subsequently, 161 kg of morpholine and 40.0 kg of sulfur were added directly to the reaction system, heated to 120 °C and kept for 5 hours. After the rearrangement reaction was completed, 500 L of methanol was added, heated to dissolve, decolorized with activated carbon, filtered and cooled. To the filtrate, 300 L of 70% ethanol and 200 L of 15% sodium hydroxide solution were added and heated to reflux for 4 hours. After completion of the reaction, filter and recover the solvent under vacuum. To the residue, appropriate amount of water was added and the pH was adjusted to 1-2 with dilute hydrochloric acid to precipitate a solid. It was filtered, washed with water to neutral, and finally recrystallized with 60% ethanol to obtain 102.2 kg of 4-bromoindole-3-acetic acid in 85.2% yield.
References
[1] Patent: CN104311469, 2016, B. Location in patent: Paragraph 0070-0072
1H-Indole-3-aceticacid,4-bromo-(9CI) Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2283 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Shanghai Jovan Biochemical Technology Co. Ltd. | +86-021-61654350 | 1245958370@qq.com | China | 2979 | 50 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
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