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Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Structure
Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) structure
CAS No.
59215-36-0
Chemical Name:
Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
Synonyms
1-(4-Methyl-2-pyrimidinyl)piperazine;4-Methyl-2-(1-piperazinyl)pyrimidine;1-(4-methyl-pyrimidin-2-yl)piperazine;Pyrimidine,4-methyl-2-(1-piperazinyl);Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
CBNumber:
CB31302986
Molecular Formula:
C9H14N4
Molecular Weight:
178.23
MDL Number:
MFCD00885955
MOL File:
59215-36-0.mol
MSDS File:
SDS
Last updated:2026-05-28 00:57:27
Product description Number Pack Size Price
4-Methyl-2-piperazin-1-ylpyrimidine 085667 1.00g $360
4-Methyl-2-(1-piperazinyl)pyrimidine 95+% AA00EAEI 100mg $144
4-Methyl-2-(1-piperazinyl)pyrimidine 95+% AA00EAEI 250mg $245
4-Methyl-2-(1-piperazinyl)pyrimidine 95+% AA00EAEI 1g $612
4-Methyl-2-(1-piperazinyl)pyrimidine 95+% AA00EAEI 5g $2141
Request For Quotation

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Properties

Melting point 45-48℃
Boiling point 170 °C(Press: 20 Torr)
Density 1+-.0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
pka 8.68±0.10(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 085667 4-Methyl-2-piperazin-1-ylpyrimidine 59215-36-0 1.00g $360 2026-05-18 Buy
aablocks AA00EAEI 4-Methyl-2-(1-piperazinyl)pyrimidine 95+% 59215-36-0 100mg $144 2026-05-28 Buy
aablocks AA00EAEI 4-Methyl-2-(1-piperazinyl)pyrimidine 95+% 59215-36-0 250mg $245 2026-05-28 Buy
aablocks AA00EAEI 4-Methyl-2-(1-piperazinyl)pyrimidine 95+% 59215-36-0 1g $612 2026-05-28 Buy
aablocks AA00EAEI 4-Methyl-2-(1-piperazinyl)pyrimidine 95+% 59215-36-0 5g $2141 2026-05-28 Buy
Product number Packaging Price Buy
085667 1.00g $360 Buy
AA00EAEI 100mg $144 Buy
AA00EAEI 250mg $245 Buy
AA00EAEI 1g $612 Buy
AA00EAEI 5g $2141 Buy

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Chemical Properties,Uses,Production

Synthesis

Piperazine

110-85-0

2-Chloro-4-methylpyrimidine

13036-57-2

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)

59215-36-0

GENERAL METHOD: 2-Chloro-4,6-disubstituted pyrimidines were prepared by reacting the diazonium salt of 4,6-disubstituted pyrimidin-2-amines with concentrated hydrochloric acid and zinc chloride. In the reference, 23 compounds were synthesized by improving the method. The procedure was as follows: 2-chloro-4-methylpyrimidine (18 mmol) was added batchwise to a stirred solution of piperazine (45 mmol) and potassium carbonate (16.5 mmol) in water (20 mL) at 50-60 °C. The reaction mixture was stirred at 60-65 °C for 1 h and subsequently cooled to room temperature. The resulting yellow solid 1,4-bis(4,6-disubstituted pyrimidin-2-yl)piperazine was collected by filtration. The filtrate was extracted three times with chloroform, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford the target product 4-methyl-2-(1-piperazinyl)pyrimidine, which could be used in the subsequent reaction without further purification. Product 3a is a yellow solid with 81% yield and 45-48°C melting point; product 3b is a yellow solid with 79% yield and 82-84°C melting point.

References

[1] Chinese Journal of Chemistry, 2015, vol. 33, # 10, p. 1124 - 1134
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 2016, vol. 191, # 1, p. 48 - 54
[3] Letters in Drug Design and Discovery, 2016, vol. 13, # 4, p. 343 - 351
[4] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 167 - 178
[5] Journal of Fluorine Chemistry, 2016, vol. 184, p. 36 - 44

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) synthesis

110-85-0
13036-57-2
59215-36-0
Synthesis of Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) from Piperazine and 2-Chloro-4-methylpyrimidine

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Preparation Products And Raw materials

Raw materials

Piperazine 2-Chloro-4-methylpyrimidine Potassium carbonate

Preparation Products

Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) Suppliers

Global( 39)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Nanjing Moldeep Biochemical Co., Ltd. 		+86-25-58282389 +8618913958656 inquiries@moldeep.com China 19946 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131956 58
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 969 56
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10186 62
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4378 65
SynAsst Chemical. 021-60343070 China 12740 55
Supplier Advantage
Alchem Pharmtech,Inc. 		58
career henan chemical co 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Nanjing Moldeep Biochemical Co., Ltd. 		58
Amadis Chemical Company Limited 		58
Carbott PharmTech Inc. 56
Pure Chemistry Scientific Inc. 62
Nanjing Vital Chemical Co., Ltd. 65
SynAsst Chemical. 55

View Lastest Price from Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI) pictures 2020-01-13 Pyrimidine,4-methyl-2-(1-piperazinyl)-(9CI)
59215-36-0
 $1.00 1g 98% 100KG Career Henan Chemical Co

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