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1-(4-Trifluoromethylpyrimidin-2-yl)piperazine

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine structure

CAS No.: 179756-91-3

Chemical Name:: 1-(4-Trifluoromethylpyrimidin-2-yl)piperazine

Synonyms: 2-PIPERAZIN-YL-4-(TRIFLUOROMETHYL)PYRIMIDINE;1-(4-Trifluoromethylpyrimidin-2-yl)piperazine;2-(1-Piperazinyl)-4-(trifluoromethyl)pyrimidine;2-(Piperazin-1-yl)-4-(trifluoromethyl)pyrimidine;1-[4-(Trifluoromethyl)pyrimid-2-yl]piperazine ,97%;Pyrimidine, 2-(1-piperazinyl)-4-(trifluoromethyl)-;1-[4-(Trifluoromethyl)-2-pyrimidinyl]piperazine, 97%;1-[4-(TrifluoroMethyl)-2-pyriMidinyl]piperazine, 97%;1-(4-Trifluoromethylpyrimidin-2-yl)piperazine ISO 9001：2015 REACH

CBNumber:: CB41471012

Molecular Formula:: C9H11F3N4

Molecular Weight:: 232.21

MDL Number:: MFCD00203912

MOL File:: 179756-91-3.mol

MSDS File:: SDS

Last updated:2026-05-28 01:16:53

Request For Quotation

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine Properties

Melting point	50-52°C
Boiling point	331.3±52.0 °C(Predicted)
Density	1.306±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
pka	8.56±0.10(Predicted)
Appearance	White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

Hazard Codes

HS Code

29335990

NFPA 704

	1
3		0

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	PC4564	1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperazine ≥95%	179756-91-3	250mg	$28	2026-06-04	Buy
Apolloscientific	PC4564	1-[4-(Trifluoromethyl)pyrimidin-2-yl]piperazine ≥95%	179756-91-3	1g	$69	2026-06-04	Buy
Matrix Scientific	085434	2-Piperazin-1-yl-4-(trifluoromethyl)pyrimidine	179756-91-3	250.00mg	$31	2026-05-18	Buy
Matrix Scientific	085434	2-Piperazin-1-yl-4-(trifluoromethyl)pyrimidine	179756-91-3	1.00g	$60	2026-05-18	Buy
Matrix Scientific	085434	2-Piperazin-1-yl-4-(trifluoromethyl)pyrimidine	179756-91-3	5.00g	$175	2026-05-18	Buy

Product number	Packaging	Price	Buy
PC4564	250mg	$28	Buy
PC4564	1g	$69	Buy
085434	250.00mg	$31	Buy
085434	1.00g	$60	Buy
085434	5.00g	$175	Buy

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine Chemical Properties,Uses,Production

Chemical Properties

Gray solid

Synthesis

110-85-0

33034-67-2

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine

179756-91-3

2-Chloro-4-trifluoromethylpyrimidine (2.0 g, 11 mmol) and piperazine (2.8 g, 33 mmol) were dissolved in DMF (10 mL) and triethylamine (3.0 mL, 22 mmol) was added as base. The reaction mixture was placed in a sealed tube and the reaction was stirred at 100 °C overnight. After completion of the reaction, most of the solvent was removed under reduced pressure. The crude product was purified by silica gel column chromatography with EtOAc to EtOAc/MeOH/NEt3 (9:1:0.5) as eluent to afford 1-(4-trifluoromethylpyrimidin-2-yl)piperazine (1.48 g, 56% yield). Mass spectrometry analysis: the calculated value (M+H) of C9H11F3N4 was 233 and the measured value was 233.1.

References

[1] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 37

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine Preparation Products And Raw materials

Raw materials

Piperazine 2-Chloro-4-(trifluoromethyl)pyrimidine Triethylamine N,N-Dimethylformamide

Preparation Products

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine Suppliers

Global( 86)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Nanjing Vital Chemical Co., Ltd.	Please Send Email 18652950785	chemweiao@163.com	China	4368	65
Shanghai Yolne Chemical Co., Ltd.	021-62960152	934678158@qq.com	China	9886	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
ShangHai AmK Pharmaceutical Technology Co., Ltd.	微信 18019252918 18019252918	sale@amkchem.com	China	14982	55
Shanghai Song Yuan Chemical Technology Co., Ltd.	010-1234567 18521000990	sonyuanchemical@163.com	China	6467	50

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Wuhan Chemwish Technology Co., Ltd	56
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Nanjing Vital Chemical Co., Ltd.	65
Shanghai Yolne Chemical Co., Ltd.	55
Bide Pharmatech Ltd.	60
ShangHai AmK Pharmaceutical Technology Co., Ltd.	55
Shanghai Song Yuan Chemical Technology Co., Ltd.	50

View Lastest Price from 1-(4-Trifluoromethylpyrimidin-2-yl)piperazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	1-(4-Trifluoromethylpyrimidin-2-yl)piperazine 179756-91-3	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2022-04-22	1-(4-Trifluoromethylpyrimidin-2-yl)piperazine 179756-91-3			98%min	100kgs/month	Shanghai Rlavie Technology Co ltd
2019-07-06	1-(4-Trifluoromethylpyrimidin-2-yl)piperazine 179756-91-3	$1.00	1kg	98%	200kg	Career Henan Chemical Co

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine
179756-91-3
$1.10
99.00%
Dideu Industries Group Limited

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine
179756-91-3
$0.00
98%min
Shanghai Rlavie Technology Co ltd

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine
179756-91-3
$1.00
98%
Career Henan Chemical Co

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine Spectrum

1-(4-Trifluoromethylpyrimidin-2-yl)piperazine(179756-91-3)¹HNMR

179756-91-3(1-(4-Trifluoromethylpyrimidin-2-yl)piperazine)Related Search:

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1-Benzhydrylpiperazine BUTTPARK 77\12-15 2-[4-[4-(Trifluoromethyl)pyrimidin-2-yl]piperazino]ethan-1-ol 2-(4-[4-(Trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl)ethylamine 1-(4-Trifluoromethylpyrimidin-2-yl)piperazine

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1-[4-(Trifluoromethyl)pyrimid-2-yl]piperazine ,97% 1-(4-Trifluoromethylpyrimidin-2-yl)piperazine 2-(Piperazin-1-yl)-4-(trifluoromethyl)pyrimidine 2-PIPERAZIN-YL-4-(TRIFLUOROMETHYL)PYRIMIDINE 1-[4-(TrifluoroMethyl)-2-pyriMidinyl]piperazine, 97% Pyrimidine, 2-(1-piperazinyl)-4-(trifluoromethyl)- 1-(4-Trifluoromethylpyrimidin-2-yl)piperazine ISO 9001：2015 REACH 2-(1-Piperazinyl)-4-(trifluoromethyl)pyrimidine 1-[4-(Trifluoromethyl)-2-pyrimidinyl]piperazine, 97% 179756-91-3 179765-91-3 pharmacetical