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2,5-Bis(trifluoromethyl)aniline

2,5-Bis(trifluoromethyl)aniline Structure
2,5-Bis(trifluoromethyl)aniline structure
CAS No.
328-93-8
Chemical Name:
2,5-Bis(trifluoromethyl)aniline
Synonyms
2,5-DI;2,5-Bis(trifL;TIMTEC-BB SBB000691;2,5-Bis(trifluoromet;Dutasteride Impurity 34;Duetasteride impurity 13;2,5-DI(TRIFLUOROMETHYL)ANILINE;2,5-BIS(TRIFLUOROMETHYL)AMILINE;2,5-BIS(TRIFLUOROMETHYL)ANILINE;2,5-DIS(TRIFLUOROMETHYL)ANILINE
CBNumber:
CB8124180
Molecular Formula:
C8H5F6N
Molecular Weight:
229.12
MDL Number:
MFCD00074940
MOL File:
328-93-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:55:59
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2,5-Bis(trifluoromethyl)aniline Properties

Boiling point 70-71 °C15 mm Hg(lit.)
Density 1.467 g/mL at 25 °C(lit.)
refractive index n20/D 1.432(lit.)
Flash point 160 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Oil
pka 0.24±0.10(Predicted)
Specific Gravity 1.467
color Clear Colourless
BRN 2653046
InChI InChI=1S/C8H5F6N/c9-7(10,11)4-1-2-5(6(15)3-4)8(12,13)14/h1-3H,15H2
InChIKey XWMVIJUAZAEWIE-UHFFFAOYSA-N
SMILES C1(N)=CC(C(F)(F)F)=CC=C1C(F)(F)F
CAS DataBase Reference 328-93-8(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,T,Xi
Risk Statements  20/21/22-36/37/38
Safety Statements  26-36/37/39-45-36
RIDADR  2810
WGK Germany  3
Hazard Note  Toxic/Irritant
HazardClass  6.1
PackingGroup  III
HS Code  29214990
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
2
2 0

2,5-Bis(trifluoromethyl)aniline price More Price(62)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 331546 2,5-Bis(trifluoromethyl)aniline 99% 328-93-8 5g $96.4 2026-04-30 Buy
TCI Chemical B2544 2,5-Bis(trifluoromethyl)aniline >98.0%(GC) 328-93-8 5g $26 2026-04-30 Buy
TCI Chemical B2544 2,5-Bis(trifluoromethyl)aniline >98.0%(GC) 328-93-8 25g $104 2026-04-30 Buy
TRC TRC-B585490-50G 2,5-Bis(trifluoromethyl)aniline 328-93-8 50g $491 2026-06-03 Buy
TRC TRC-B585490-1G 2,5-Bis(trifluoromethyl)aniline 328-93-8 1g $65 2026-06-03 Buy
Product number Packaging Price Buy
331546 5g $96.4 Buy
B2544 5g $26 Buy
B2544 25g $104 Buy
TRC-B585490-50G 50g $491 Buy
TRC-B585490-1G 1g $65 Buy

2,5-Bis(trifluoromethyl)aniline Chemical Properties, Uses, Production

Chemical Properties

Clear colorless liquid

Uses

2,5-Bis(trifluoromethyl)aniline is a haloalkul substituted aniline used in the preparation of anti-benign prostatic hyperplasia drug, Dutasteride (D735000).

Uses

2,5-Bis(trifluoromethyl)aniline may be used in chemical synthesis.

Synthesis

2,5-Bis(trifluoromethyl)nitrobenzene

320-88-7

2,5-Bis(trifluoromethyl)aniline

328-93-8

Example 8: To an autoclave was added 1.05 g of Raney nickel catalyst (10 wt%) and 100 mL of isopropanol followed by 10.0 g of 2,5-bis(trifluoromethyl)nitrobenzene. Hydrogen was passed under stirring until the pressure reached 5 kg/cm2 and the temperature was raised to 70 °C. The reaction was continued at 70-90°C for 8 hours. After completion of the reaction, the temperature was allowed to drop to room temperature, the hydrogen pressure was released, the catalyst was removed by filtration and the filtrate was washed with isopropanol. The filtrate was concentrated to give 6.42 g of 2,5-bis(trifluoromethyl)aniline in 73% yield and 99.4% GC purity. The structure of the product was confirmed by GC-MS, 1H-NMR and 19F-NMR analysis.

References

[1] Patent: EP1468983, 2004, A1. Location in patent: Page 6
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 4967
[3] Patent: WO2011/150156, 2011, A2. Location in patent: Page/Page column 132

2,5-Bis(trifluoromethyl)aniline synthesis

320-88-7
328-93-8
Synthesis of 2,5-Bis(trifluoromethyl)aniline from 2,5-Bis(trifluoromethyl)nitrobenzene

2,5-Bis(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

2-Pyridinecarboxamide, N-[3-(trifluoromethyl)phenyl]- 1,4-Bis(trifluoromethyl)-benzene 1,4-Bis(trichloromethyl)-2-chlorobenzene 2,5-Bis(trifluoromethyl)nitrobenzene Nickel
2,5-Bis(trifluoromethyl)chlorobenzene Isopropyl alcohol Hydrogen

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Preparation Products

4-Trifluoromethylsalicylic acid

2,5-Bis(trifluoromethyl)aniline Suppliers

Global Suppliers ( 368)
Supplier Tel Email Country ProdList Advantage
Fuxin Simai Chemical Technology Co., Ltd. 13841818553 929964679@qq.com China 446 58
iFar Chemical Technology 0086-510-83488850 sales@ifar.com.cn China 49 50
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Fuxin Simai Chemical Technology Co., Ltd. 58
iFar Chemical Technology 50
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61

View Latest Price from 2,5-Bis(trifluoromethyl)aniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,5-Bis(trifluoromethyl)aniline pictures 2026-09-15 2,5-Bis(trifluoromethyl)aniline
328-93-8
 25KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2,5-Bis(trifluoromethyl)aniline pictures 2026-08-20 2,5-Bis(trifluoromethyl)aniline
328-93-8
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2,5-Bis(trifluoromethyl)aniline pictures 2026-03-20 2,5-Bis(trifluoromethyl)aniline
328-93-8
 $1.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd

2,5-Bis(trifluoromethyl)aniline Spectrum

2,5-Bis(trifluoromethyl)aniline(328-93-8)1HNMR2,5-Bis(trifluoromethyl)aniline(328-93-8)IR2,5-Bis(trifluoromethyl)aniline(328-93-8)FT-IR2,5-Bis(trifluoromethyl)aniline(328-93-8)Raman

328-93-8 (2,5-Bis(trifluoromethyl)aniline) Related Search:

N-Methylaniline 3-(Trifluoromethyl)benzaldehyde Acid Blue 93 p-Toluidine 3-Aminobenzotrifluoride
2-(Trifluoromethyl)benzoic acid 4-Aminobenzotrifluoride 4-(Trifluoromethoxy)aniline 2-Fluoroaniline 3,3',5,5'-Tetramethylbenzidine dihydrochloride
4-Fluoroaniline N,N-Dimethylaniline Dutasteride N,N-Dimethyl-1,4-phenylenediamine 2,5-Bis(trifluoromethyl)nitrobenzene
2-Aminobenzotrifluoride Aniline o-Toluidine

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ALPHA,ALPHA,ALPHA,ALPHA',ALPHA',ALPHA'-HEXAFLUORO-2,5-XYLIDINE 2,5-DI(TRIFLUOROMETHYL)ANILINE 2,5-BIS(TRIFLUOROMETHYL)ANILINE TIMTEC-BB SBB000691 2,5-BIS(TRIFLUOROMETHYL)AMILINE 2,5-Bis(trifluoromethyl)aniline 98% 2,5-Bis(trifluoromethyl)aniline98% 2,5-DIS(TRIFLUOROMETHYL)ANILINE 2,5-Bis-trifluoromethyl-phenylamine 2,5-bis(trifluoromethyl)benzenamine 2,5-DI 2,5-Bis(trifluoromet 2,5-BIS(TRIFLUORO METHUYL) ANILINE 1-Amino-2,5-bis(trifluoromethyl)benzene α,α,α,α',α',α'-Hexafluoro-2,5-xylidine Dutasteride Impurity 34 2, 5 - two (three fluorinated Methyl) aniline 2,5-Bis(trifluoromethyl)aniline,99% 2,5-Bis(trifluoromethyl)aniline > 2,5-Bis(trifL Benzenamine, 2,5-bis(trifluoromethyl)- 2,5-Bis(trifluoromethyl)aniline ISO 9001：2015 REACH 2,5-bis(trifluoromethyl)aniline/Manufacturer/High quality/Best price Duetasteride impurity 13 328-93-8 328-93-9 28-93-8 CF32C6H3NH2 AMINE Nitrogen Compounds Organic Building Blocks Building Blocks Amines C8 Aniline series Nitrogen Compounds Amines C8 Anilines, Aromatic Amines and Nitro Compounds Fluorobenzene