5-Bromoisoquinoline
- CAS No.
- 34784-04-8
- Chemical Name:
- 5-Bromoisoquinoline
- Synonyms
- 5-BromoisoquinoL;AKOS BBS-00003132;BUTTPARK 44\07-76;5-BROMOISOQUINOLINE;5-Bromo Isoquinolin;Isoquinoline, 5-bromo-;5-Bromoisoquinoline,97%;5-Bromoisoquinoline,98%;5-Bromoisoquinoline >5-Bromoisoquinoline, HCl
- CBNumber:
- CB3135741
- Molecular Formula:
- C9H6BrN
- Molecular Weight:
- 208.05
- MDL Number:
- MFCD01646405
- MOL File:
- 34784-04-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 83-87 °C (lit.) |
|---|---|
| Boiling point | 95-97°C 0,1mm |
| Density | 1.564±0.06 g/cm3(Predicted) |
| Flash point | 95-97°C/0.1mm |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Dichloromethane, Ethyl Acetate, Methanol |
| form | Solid |
| pka | 4.39±0.13(Predicted) |
| color | Yellow |
| BRN | 114468 |
| InChI | InChI=1S/C9H6BrN/c10-9-3-1-2-7-6-11-5-4-8(7)9/h1-6H |
| InChIKey | CYJZJGYYTFQQBY-UHFFFAOYSA-N |
| SMILES | C1C2=C(C(Br)=CC=C2)C=CN=1 |
| CAS DataBase Reference | 34784-04-8(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-21/22-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29334900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
5-Bromoisoquinoline price More Price(88)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 594261 | 5-Bromoisoquinoline 98% | 34784-04-8 | 1g | $25 | 2023-01-07 | Buy |
| Sigma-Aldrich | 594261 | 5-Bromoisoquinoline 98% | 34784-04-8 | 5g | $29 | 2023-01-07 | Buy |
| TCI Chemical | B3313 | 5-Bromoisoquinoline >96.0%(GC)(T) | 34784-04-8 | 1g | $27 | 2026-04-30 | Buy |
| TCI Chemical | B3313 | 5-Bromoisoquinoline >96.0%(GC)(T) | 34784-04-8 | 5g | $80 | 2026-04-30 | Buy |
| Cayman Chemical | 10007079 | 5-Bromoisoquinoline ≥99% | 34784-04-8 | 500mg | $32 | 2026-04-30 | Buy |
5-Bromoisoquinoline Chemical Properties, Uses, Production
Description
5-
Chemical Properties
White to yellow-brown crystals
Uses
Starting material employed in palladium-catalyzed aminomethylation and amination reactions.
Synthesis Reference(s)
[1] W. Brown, A. Gouliaev. “Bromination of Isoquinoline, Quinoline, Quinazoline and Quinoxaline in Strong Acid.” ChemInform 98 1 (2002).
Synthesis
To mechanically stirred concd H2SO4 (42.5 mL) at 0 °C, isoquinoline (1; 5 mL, 42.5 mmol) was slowly added. The mixture was cooled to –25 °C, and NBS (9.83 g, 55.2 mmol) was added at such a rate that the reaction temperature was kept between –25 °C and –22 °C. The mixture was stirred at -22±1 °C for 2 h and at -18±1 °C for 3h. The mixture was then worked up as described above to give 6.16 g (72%) as a slightly off-white solid after chromatography; mp 81–82 °C. The solid was further purified by sublimation (75 °C/0.2 mmHg) to give 5-Bromoisoquinoline as a white powder[1].
References
[1] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 22
[2] Patent: WO2009/23844, 2009, A2. Location in patent: Page/Page column 105-106
[3] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 45; 45-46
[4] Patent: US2010/16297, 2010, A1. Location in patent: Page/Page column 25
[5] Patent: WO2010/21797, 2010, A1. Location in patent: Page/Page column 68
5-Bromoisoquinoline Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Anchor Biological Technology Co., Ltd | 0519-85519868 18915088878 | sales@ankerbio.com | China | 260 | 58 |
| Tongchuang Pharma(Suzhou). Co., Ltd. | 0512-63263366 18912765016 | tongtf110@sina.com | China | 984 | 62 |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
| Fuxin Kaituo Fine Chemical Technology Co., Ltd | 15714082442 | 3757845877@qq.com | China | 343 | 58 |
| Nantong Xiaochang Pharmaceutical Trading Co., Ltd. | 0513-82104991 15152894157 | sales11@btcpharm.com | China | 860 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Bridge Organics | +1269-649-4200 | ab@bridgeorganics.com | United States | 160 | 55 |
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
View Latest Price from 5-Bromoisoquinoline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-Bromoisoquinoline
34784-04-8
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited | |
 |
2021-10-14 | 5-Bromoisoquinoline
34784-04-8
|
$10.00 | 1KG | 99% | 20 tons | Hebei Zhanyao Biotechnology Co. Ltd | |
 |
2019-07-06 | 5-Bromoisoquinoline
34784-04-8
|
$1.00 | 1kg | 99% | 200kg | Career Henan Chemical Co |
-
- 5-Bromoisoquinoline
34784-04-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Bromoisoquinoline
34784-04-8
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
-
- 5-Bromoisoquinoline
34784-04-8
- $1.00
- 99%
- Career Henan Chemical Co
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