FRG 8701
- CAS No.
- 108498-50-6
- Chemical Name:
- FRG 8701
- Synonyms
- FRG 8701;FRG8701,FRG-8701;N-(3-(3-(Piperidinylmethyl)phenoxy)propyl)-2-(furfurylsulfinyl)acetamide;Acetamide, 2-[(2-furanylmethyl)sulfinyl]-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-
- CBNumber:
- CB31376213
- Molecular Formula:
- C22H30N2O4S
- Molecular Weight:
- 418.55
- MDL Number:
- MFCD00876895
- MOL File:
- 108498-50-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
FRG 8701 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | IEA49850 | N-(3-(3-(Piperidinylmethyl)phenoxy)propyl)-2-(furfurylsulfinyl)acetamide | 108498-50-6 | 1mg | $3883.62 | 2026-06-04 | Buy |
| Arctom | BD-A1371246 | FRG8701 98+% | 108498-50-6 | 5mg | $2203 | 2026-05-26 | Buy |
| CSNpharm | CSN22023 | FRG8701 | 108498-50-6 | 1mg | $1306 | 2021-12-16 | Buy |
| CSNpharm | CSN22023 | FRG8701 | 108498-50-6 | 25mg | $7834 | 2021-12-16 | Buy |
FRG 8701 Chemical Properties, Uses, Production
Uses
FRG-8701 is a new Histamine H2-receptor antagonist with an IC50 of ranging from 0.25 to 0.43 μM.
in vivo
In the pylorus-ligated (4 hr) rats, each drug, given intraduodenally, dose-dependently inhibits the total acid output. FRG8701 at 10 or 30 mg/kg, given orally or intraperitoneally, significantly prevent the formation of the gastric mucosal lesions induced by 0.4 N HCI+50% ethanol (HCIethanol). Other necrotizing agents-induced gastric lesions are also inhibited by treatment of FRG8701. The oral ED50 values against the lesions range from 1.1 to 9.4 mg/kg. FRG8701, given orally, dose-dependently prevents the development of gastric lesions induced by stress and indomethacin. Duodenal ulcer induced by mepirizole is also inhibited with FRG8701. The ED50 values of FRG8701 for each ulcer model range from 1.7 to 6.9 mg/kg[1].
References
[1] Shibata M,et al. Effects of FRG-8701 on gastric acid secretion, gastric mucosal lesions by necrotizing agents and experimental gastric or duodenal ulcer in rats. Jpn J Pharmacol. 1990 Nov;54(3):277-85. DOI:10.1254/jjp.54.277
FRG 8701 Preparation Products And Raw materials
Raw materials
Preparation Products
FRG 8701 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
