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JAK-IN-30

JAK-IN-30 Structure
JAK-IN-30 structure
CAS No.
2891469-99-9
Chemical Name:
JAK-IN-30
Synonyms
JAK-IN-30;JAK Inhibitor 31;3-Azetidineacetonitrile, 1-[5-methyl-2-[(3-methyl-5-isothiazolyl)amino]-4-pyrimidinyl]-3-(4-methyl-1-piperazinyl)-
CBNumber:
CB314133733
Molecular Formula:
C19H26N8S
Molecular Weight:
398.53
MDL Number:
MOL File:
2891469-99-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:58:52
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JAK-IN-30 Properties

Boiling point 565.197±60.00 °C(Press: 760.00 Torr)(predicted)
Density 1.304±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
solubility DMF: 30 mg/ml
DMSO: 30 mg/ml
Ethanol: 10 mg/mlPBS (pH 7.2): Slightly soluble
pka 8.074±0.42(predicted)

JAK-IN-30 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 39387 JAK Inhibitor 31 ≥98% 2891469-99-9 1mg $55 2026-04-30 Buy
Cayman Chemical 39387 JAK Inhibitor 31 ≥98% 2891469-99-9 5mg $220 2026-04-30 Buy
Cayman Chemical 39387 JAK Inhibitor 31 ≥98% 2891469-99-9 10mg $385 2026-04-30 Buy
ChemScene CS-0880259 JAK-IN-30 2891469-99-9 1mg $141 2026-06-04 Buy
ChemScene CS-0880259 JAK-IN-30 2891469-99-9 5mg $536 2026-06-04 Buy
Product number Packaging Price Buy
39387 1mg $55 Buy
39387 5mg $220 Buy
39387 10mg $385 Buy
CS-0880259 1mg $141 Buy
CS-0880259 5mg $536 Buy

JAK-IN-30 Chemical Properties, Uses, Production

Uses

JAK-IN-30 (compound 31) is a water-soluble JAK inhibitor with IC50 values of 2, 15, 18 and 2 nM for JAK2, JAK1, JAK3 and TYK2, respectively. JAK-IN-30 has research potential for dry eye disease (DED)[1].

IC 50

JAK1: 15 nM (IC50); JAK2: 2 nM (IC50); JAK3: 18 nM (IC50); Tyk2: 2 nM (IC50)

References

[1] Gordhan HM, et al. Eyes on Topical Ocular Disposition: The Considered Design of a Lead Janus Kinase (JAK) Inhibitor That Utilizes a Unique Azetidin-3-Amino Bridging Scaffold to Attenuate Off-Target Kinase Activity, While Driving Potency and Aqueous Solubility. J Med Chem. 2023 Jul 13;66(13):8929-8950. DOI:10.1021/acs.jmedchem.3c00519

JAK-IN-30 Preparation Products And Raw materials

Raw materials

Preparation Products

JAK-IN-30 Suppliers

Global Suppliers ( 6)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58

2891469-99-9 (JAK-IN-30) Related Search:

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2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-(2,2-dimethyl-1-propoxypropyl)-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)-

1of2

JAK-IN-30 JAK Inhibitor 31 3-Azetidineacetonitrile, 1-[5-methyl-2-[(3-methyl-5-isothiazolyl)amino]-4-pyrimidinyl]-3-(4-methyl-1-piperazinyl)- 2891469-99-9