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2-Hydroxy-4-methylpyridine-3-carbonitrile

2-Hydroxy-4-methylpyridine-3-carbonitrile structure

CAS No.: 93271-59-1

Chemical Name:: 2-Hydroxy-4-methylpyridine-3-carbonitrile

Synonyms: 2-hydroxy-4-Methylnicotinonitrile;4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;4-methyl-2-oxo-1H-pyridine-3-carbonitrile;1,2-dihydro-4-Methyl-2-oxo-3-Pyridinecarbonitrile;3-Cyano-4-methyl-2-pyridone;3-Cyano-2-hydroxy-4-methylpyridine;2-Hydroxy-4-methylpyridine-3-carbonitrile;1,2-dihydro-4-Methyl-2-oxopyridine-3-carbonitrile;3-Pyridinecarbonitrile,1,2-dihydro-4-Methyl-2-oxo-;4-methyl-2-oxo-1H-pyridine-3-carbonitrile - [M87955]

CBNumber:: CB31457086

Molecular Formula:: C7H6N2O

Molecular Weight:: 134.14

MDL Number:: MFCD00716620

MOL File:: 93271-59-1.mol

MSDS File:: SDS

Last updated:2026-07-01 20:51:29

Product description	Number	Pack Size	Price
3-Cyano-2-hydroxy-4-methylpyridine >97%	OR300781	1g	$21
3-Cyano-2-hydroxy-4-methylpyridine >97%	OR300781	5g	$44
3-Cyano-4-methyl-2-pyridone 97%	AS22536	1g	$32
3-Cyano-2-hydroxy-4-methylpyridine >97%	OR300781	25g	$134
3-Cyano-4-methyl-2-pyridone 97%	AS22536	5g	$79
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2-Hydroxy-4-methylpyridine-3-carbonitrile Properties

Melting point	234.7-236.1 °C
Boiling point	337.7±35.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	Storage temp. 2-8°C
pka	8.96±0.10(Predicted)
Appearance	Light yellow to yellow Solid
InChI	InChI=1S/C7H6N2O/c1-5-2-3-9-7(10)6(5)4-8/h2-3H,1H3,(H,9,10)
InChIKey	XSJRLWNOZDULKJ-UHFFFAOYSA-N
SMILES	C1(=O)NC=CC(C)=C1C#N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P280-P310-P305+P351+P338
HS Code	2933399990

2-Hydroxy-4-methylpyridine-3-carbonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR300781	3-Cyano-2-hydroxy-4-methylpyridine >97%	93271-59-1	1g	$21	2026-06-04	Buy
Apolloscientific	OR300781	3-Cyano-2-hydroxy-4-methylpyridine >97%	93271-59-1	5g	$44	2026-06-04	Buy
Activate Scientific	AS22536	3-Cyano-4-methyl-2-pyridone 97%	93271-59-1	1g	$32	2026-06-04	Buy
Apolloscientific	OR300781	3-Cyano-2-hydroxy-4-methylpyridine >97%	93271-59-1	25g	$134	2026-06-04	Buy
Activate Scientific	AS22536	3-Cyano-4-methyl-2-pyridone 97%	93271-59-1	5g	$79	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR300781	1g	$21	Buy
OR300781	5g	$44	Buy
AS22536	1g	$32	Buy
OR300781	25g	$134	Buy
AS22536	5g	$79	Buy

2-Hydroxy-4-methylpyridine-3-carbonitrile Chemical Properties,Uses,Production

Synthesis

5436-21-5

107-91-5

2-Hydroxy-4-methylpyridine-3-carbonitrile

93271-59-1

Ammonium acetate (79.3 mg, 1.03 mmol) and acetic acid (0.6 mL) were added to anhydrous toluene (12.4 mL) as 4,4-dimethoxy-2-butanone (2.0 g, 15.13 mmol) and cyanoacetamide (1.6 g, 18.92 mmol) in an anhydrous toluene (12.4 mL) assembled in a Dean-Stark device and stirred and refluxed for 8 hr to remove the resulting water. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure, and the residual oily substance was cooled to room temperature and ethanol (7.0 mL) was added at 25 °C with stirring. Subsequently, 50% sulfuric acid (2.6 mL) was added slowly and the mixture was heated at 50 °C with stirring for 3 hours. After the reaction mixture was cooled to 5 °C, water (1.3 mL) was slowly added. The resulting brown solid was purified by crystallization in ethanol to give 2-hydroxy-3-cyano-4-methylpyridine (0.900 g, yield: 45%); melting point: 233-236 °C. 1H NMR (400 MHz, DMSO-d6): δ 12.58 (br s, 1H, NH), 8.04 (d, J = 7.4 Hz, 1H, H-6), 6.24 ( d, J = 7.4 Hz, 1H, H-5), 2.31 (s, 3H, CH3).

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 155 - 171

2-Hydroxy-4-methylpyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Acetylacetaldehyde dimethyl acetal Propanedinitrile, 2-[(2E)-3-methoxy-1-methyl-2-propen-1-ylidene]- Propanedinitrile, 2-(3,3-diMethoxy-1-Methylpropylidene)- 2-Cyanoacetamide Ammonium acetate

Acetic acid Sulfuric acid Ethanol Water Toluene

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Preparation Products

2-Hydroxy-4-methylpyridine-3-carbonitrile Suppliers

Global( 126)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2994	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29792	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	9976	58
Shanghai Rlavie Technology Co ltd	+86-021-67759270 +8617717059219	sales@rlavie.com	China	1030	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30224	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Zhejiang ZETian Fine Chemicals Co. LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Shanghai Rlavie Technology Co ltd	58
Career Henan Chemica Co	58

View Lastest Price from 2-Hydroxy-4-methylpyridine-3-carbonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-01	2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2025-11-18	2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2025-04-04	2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1		1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2-Hydroxy-4-methylpyridine-3-carbonitrile
93271-59-1
98%
Shaanxi Dideu New Materials Co. Ltd

2-Hydroxy-4-methylpyridine-3-carbonitrile
93271-59-1
$1.10
99.00%
Dideu Industries Group Limited

2-Hydroxy-4-methylpyridine-3-carbonitrile
93271-59-1
98%
Henan Aochuang Chemical Co.,Ltd.

2-Hydroxy-4-methylpyridine-3-carbonitrile Spectrum

2-Hydroxy-4-methylpyridine-3-carbonitrile(93271-59-1)¹HNMR

93271-59-1(2-Hydroxy-4-methylpyridine-3-carbonitrile)Related Search:

1-Ethyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one ETHYL 2-(6'-CYANO-5'-OXO-3',5'-DIHYDRO-2'H-SPIRO[[1,3]DIOXOLANE-2,1'-INDOLIZINE]-7'-YL)ACETATE 2-HYDROXY-4-METHOXYMETHYL-6-METHYLNICOTINONITRILE 3-Cyano-4,6-dimethyl-2-hydroxypyridine

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ETHYL 3-CYANO-2-HYDROXY-6-METHYLISONICOTINATE 7-METHYL-1,5-DIOXO-1,2,3,5-TETRAHYDRO-INDOLIZINE-6-CARBONITRILE METHYL 6-CYANO-1-HYDROXY-7-METHYL-5-OXO-3,5-DIHYDROINDOLIZINE-2-CARBOXYLATE

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2-Hydroxy-4-methylpyridine-3-carbonitrile 3-Cyano-4-methyl-2-pyridone 1,2-dihydro-4-Methyl-2-oxopyridine-3-carbonitrile 3-Cyano-2-hydroxy-4-methylpyridine 3-Pyridinecarbonitrile,1,2-dihydro-4-Methyl-2-oxo- 2-Hydroxy-4-methylpyridine-3-carbonitrile ISO 9001：2015 REACH 4-methyl-2-oxo-1H-pyridine-3-carbonitrile - [M87955] 1,2-dihydro-4-Methyl-2-oxo-3-Pyridinecarbonitrile 2-hydroxy-4-Methylnicotinonitrile 4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 4-methyl-2-oxo-1H-pyridine-3-carbonitrile 93271-59-1 Pyridine