ChemicalBook >> CAS DataBase List >>2-Hydroxy-4-methylpyridine-3-carbonitrile

2-Hydroxy-4-methylpyridine-3-carbonitrile

2-Hydroxy-4-methylpyridine-3-carbonitrile structure

CAS No.: 93271-59-1

Chemical Name:: 2-Hydroxy-4-methylpyridine-3-carbonitrile

Synonyms: 2-hydroxy-4-Methylnicotinonitrile;4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile;4-methyl-2-oxo-1H-pyridine-3-carbonitrile;1,2-dihydro-4-Methyl-2-oxo-3-Pyridinecarbonitrile;3-Cyano-4-methyl-2-pyridone;3-Cyano-2-hydroxy-4-methylpyridine;2-Hydroxy-4-methylpyridine-3-carbonitrile;1,2-dihydro-4-Methyl-2-oxopyridine-3-carbonitrile;3-Pyridinecarbonitrile,1,2-dihydro-4-Methyl-2-oxo-;4-methyl-2-oxo-1H-pyridine-3-carbonitrile - [M87955]

CBNumber:: CB31457086

Molecular Formula:: C7H6N2O

Molecular Weight:: 134.14

MDL Number:: MFCD00716620

MOL File:: 93271-59-1.mol

MSDS File:: SDS

Last updated:2026-07-01 20:51:29

Request For Quotation

2-Hydroxy-4-methylpyridine-3-carbonitrile Properties

Melting point	234.7-236.1 °C
Boiling point	337.7±35.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	Storage temp. 2-8°C
pka	8.96±0.10(Predicted)
Appearance	Light yellow to yellow Solid
InChI	InChI=1S/C7H6N2O/c1-5-2-3-9-7(10)6(5)4-8/h2-3H,1H3,(H,9,10)
InChIKey	XSJRLWNOZDULKJ-UHFFFAOYSA-N
SMILES	C1(=O)NC=CC(C)=C1C#N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P280-P310-P305+P351+P338
HS Code	2933399990

2-Hydroxy-4-methylpyridine-3-carbonitrile price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR300781	3-Cyano-2-hydroxy-4-methylpyridine >97%	93271-59-1	1g	$21	2026-06-04	Buy
Apolloscientific	OR300781	3-Cyano-2-hydroxy-4-methylpyridine >97%	93271-59-1	5g	$44	2026-06-04	Buy
Activate Scientific	AS22536	3-Cyano-4-methyl-2-pyridone 97%	93271-59-1	1g	$32	2026-06-04	Buy
Apolloscientific	OR300781	3-Cyano-2-hydroxy-4-methylpyridine >97%	93271-59-1	25g	$134	2026-06-04	Buy
Activate Scientific	AS22536	3-Cyano-4-methyl-2-pyridone 97%	93271-59-1	5g	$79	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR300781	1g	$21	Buy
OR300781	5g	$44	Buy
AS22536	1g	$32	Buy
OR300781	25g	$134	Buy
AS22536	5g	$79	Buy

2-Hydroxy-4-methylpyridine-3-carbonitrile Chemical Properties, Uses, Production

Synthesis

5436-21-5

107-91-5

2-Hydroxy-4-methylpyridine-3-carbonitrile

93271-59-1

Ammonium acetate (79.3 mg, 1.03 mmol) and acetic acid (0.6 mL) were added to anhydrous toluene (12.4 mL) as 4,4-dimethoxy-2-butanone (2.0 g, 15.13 mmol) and cyanoacetamide (1.6 g, 18.92 mmol) in an anhydrous toluene (12.4 mL) assembled in a Dean-Stark device and stirred and refluxed for 8 hr to remove the resulting water. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure, and the residual oily substance was cooled to room temperature and ethanol (7.0 mL) was added at 25 °C with stirring. Subsequently, 50% sulfuric acid (2.6 mL) was added slowly and the mixture was heated at 50 °C with stirring for 3 hours. After the reaction mixture was cooled to 5 °C, water (1.3 mL) was slowly added. The resulting brown solid was purified by crystallization in ethanol to give 2-hydroxy-3-cyano-4-methylpyridine (0.900 g, yield: 45%); melting point: 233-236 °C. 1H NMR (400 MHz, DMSO-d6): δ 12.58 (br s, 1H, NH), 8.04 (d, J = 7.4 Hz, 1H, H-6), 6.24 ( d, J = 7.4 Hz, 1H, H-5), 2.31 (s, 3H, CH3).

References

[1] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 155 - 171

2-Hydroxy-4-methylpyridine-3-carbonitrile Preparation Products And Raw materials

Raw materials

Acetylacetaldehyde dimethyl acetal Propanedinitrile, 2-[(2E)-3-methoxy-1-methyl-2-propen-1-ylidene]- Propanedinitrile, 2-(3,3-diMethoxy-1-Methylpropylidene)- 2-Cyanoacetamide Ammonium acetate

Acetic acid Sulfuric acid Ethanol Water Toluene

1of2

Preparation Products

2-Hydroxy-4-methylpyridine-3-carbonitrile Suppliers

Global Suppliers ( 125)

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Guanzhongtong Technology Co.,LTD	0716-7227299 13507251920	finecq@163.com	China	34	58
Suzhou Skenoson Biological Technology Co. LTD	19951323309	1158718798@qq.com	China	352	58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.	13761987713; 13761987713	hxzheng@sunwaypharm.cn	China	9905	58
Hangzhou Copiore Chemical Co., Ltd.	17300981287 13757145729	sales@copiore.com	China	291	58
PharmaBlock Sciences (Nanjing),Inc.	025-86918202 4000255188	sales@pharmablock.com	China	5000	55
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Ennopharm Co., Ltd.	+86 (21) 6435-5022		China	4263	65
China Langchem Inc.	021-58956006,021-58950017 15800617331	sales@langchem.com	China	209	57

Supplier	Advantage
Hubei Guanzhongtong Technology Co.,LTD	58
Suzhou Skenoson Biological Technology Co. LTD	58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.	58
Hangzhou Copiore Chemical Co., Ltd.	58
PharmaBlock Sciences (Nanjing),Inc.	55
Capot Chemical Co., Ltd	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Accela ChemBio Co.,Ltd.	64
Shanghai Ennopharm Co., Ltd.	65
China Langchem Inc.	57

View Latest Price from 2-Hydroxy-4-methylpyridine-3-carbonitrile manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2026-07-01	2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1		1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2025-04-04	2-Hydroxy-4-methylpyridine-3-carbonitrile 93271-59-1		1KG	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

2-Hydroxy-4-methylpyridine-3-carbonitrile
93271-59-1
$1.10
99.00%
Dideu Industries Group Limited

2-Hydroxy-4-methylpyridine-3-carbonitrile
93271-59-1
98%
Shaanxi Dideu New Materials Co. Ltd

2-Hydroxy-4-methylpyridine-3-carbonitrile
93271-59-1
98%
Henan Aochuang Chemical Co.,Ltd.

2-Hydroxy-4-methylpyridine-3-carbonitrile Spectrum

2-Hydroxy-4-methylpyridine-3-carbonitrile(93271-59-1)¹HNMR

93271-59-1 (2-Hydroxy-4-methylpyridine-3-carbonitrile) Related Search:

7'-Methyl-5'-oxo-3',5'-dihydro-2'H-spiro[[1,3]dioxolane-2,1'-indolizine]-6'-carbonitrile 2-Hydroxy-4-methoxymethyl-6-methylnicotinonitrile N-Butyl-3-cyano-6-hydroxy-4-methyl-2-pyridone 3-Cyano-4,6-dimethyl-2-hydroxypyridine 3-Cyano-2,6-dihydroxy-4-methylpyridine

1-Ethyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 1,4-Dimethyl-3-cyano-6-hydroxypyrid-2-one Ethyl 2-(6'-cyano-5'-oxo-3',5'-dihydro-2'H-spiro[[1,3]dioxolane-2,1'-indolizine]-7'-yl)acetate 5-Bromo-2-hydroxy-4,6-dimethyl-nicotinonitrile 6-hydroxy-1-(3-methoxypropyl)-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile

1-Amino-4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 2-Hydroxy-4,5,6-trimethylnicotinonitrile Quinoxalin-5-amine Methyl 6-cyano-1-hydroxy-7-methyl-5-oxo-3,5-dihydroindolizine-2-carboxylate 7-Methyl-1,5-dioxo-1,2,3,5-tetrahydro-indolizine-6-carbonitrile

Ethyl 3-cyano-2-hydroxy-6-methylisonicotinate 5-Chloro-2-hydroxy-4,6-dimethylnicotinonitrile 2-Hydroxy-6-(2-thienyl)-4-(trifluoromethyl)nicotinonitrile

1of4

2-Hydroxy-4-methylpyridine-3-carbonitrile 3-Cyano-4-methyl-2-pyridone 1,2-dihydro-4-Methyl-2-oxopyridine-3-carbonitrile 3-Cyano-2-hydroxy-4-methylpyridine 3-Pyridinecarbonitrile,1,2-dihydro-4-Methyl-2-oxo- 2-Hydroxy-4-methylpyridine-3-carbonitrile ISO 9001：2015 REACH 4-methyl-2-oxo-1H-pyridine-3-carbonitrile - [M87955] 1,2-dihydro-4-Methyl-2-oxo-3-Pyridinecarbonitrile 2-hydroxy-4-Methylnicotinonitrile 4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile 4-methyl-2-oxo-1H-pyridine-3-carbonitrile 93271-59-1 Pyridine