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GW-501516

GW-501516 Structure
GW-501516 structure
CAS No.
317318-70-0
Chemical Name:
GW-501516
Synonyms
CARDARINE;GW 1516;2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid;ENDUROBOL;CS-788;GSK-516;CARDAROL;GW-501615;Cardrarine;GW501516 20mg
CBNumber:
CB31476045
Molecular Formula:
C21H18F3NO3S2
Molecular Weight:
453.5
MDL Number:
MFCD09033000
MOL File:
317318-70-0.mol
MSDS File:
SDS
Last updated:2025-09-28 08:52:25
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GW-501516 Properties

Melting point 134-136°C
Boiling point 584.5±60.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: soluble20mg/mL, clear
form powder
pka 3.17±0.10(Predicted)
color white to beige
BRN 18515150
Stability Light Sensitive
InChI InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)
InChIKey YDBLKRPLXZNVNB-UHFFFAOYSA-N
SMILES C(O)(=O)COC1=CC=C(SCC2SC(C3=CC=C(C(F)(F)F)C=C3)=NC=2C)C=C1C
CAS DataBase Reference 317318-70-0
FDA UNII 7I2HA1NU22
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
WGK Germany  3
RTECS  AI9105500
NFPA 704
0
2 0

GW-501516 price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1491 {2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid ≥98% (HPLC) 317318-70-0 5mg $108.3 2025-07-31 Buy
Sigma-Aldrich 43732 {2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid analytical standard 317318-70-0 25mg $281 2022-05-15 Buy
Cayman Chemical 10004272 GW 501516 ≥98% 317318-70-0 1mg $44 2024-03-01 Buy
Cayman Chemical 10004272 GW 501516 ≥98% 317318-70-0 5mg $87 2024-03-01 Buy
Sigma-Aldrich SML1491 {2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid ≥98% (HPLC) 317318-70-0 25mg $462 2025-07-31 Buy
Product number Packaging Price Buy
SML1491 5mg $108.3 Buy
43732 25mg $281 Buy
10004272 1mg $44 Buy
10004272 5mg $87 Buy
SML1491 25mg $462 Buy

GW-501516 Chemical Properties,Uses,Production

Description

GW501516, also known as GW-1516 or cardarine and endurobol, is a peroxisome proliferator-activated receptor delta (PPAR-δ) agonist. Activation of the receptor will increase fat-burning capacity and muscle production, as it changes the body's fuel preference from glucose to lipids.

Description

Peroxisome proliferator-activated receptor δ (PPARδ) stimulation or over-expression in adipocytes leads to increased fatty acid oxidation, improved exercise tolerance, and resistance to obesity. GW 501516 is the first highly selective synthetic PPARδ agonist available. GW 501516 binds to human PPARδ with an IC50 value of 1 nM, and is at least 100-fold selective for PPARδ compared to PPARα and PPARγ. In obese primates, GW 501516 increases high density lipoprotein cholesterol and apolipoprotein A-1 specific reverse cholesterol transport. GW 501516 is therefore a model compound for a new type of obesity therapeutic, as well as a selective pharmacological tool for understanding lipid metabolism.

Chemical Properties

White Solid

History

GW501516, also known as Cardarine, was originally discovered in the early 1990s during a research collaboration between two large pharmaceutical companies. The initial proposed use was for the treatment of hyperlipidemia (elevated fats in the blood), though later studies looked at its effectiveness for treating obesity, diabetes, and cardiovascular disease.

Uses

GW501516 has been used to study its effect on mutation-driven colorectal tumorigenesis and tumor invasion using mouse model.

Uses

An experimental drug meant to control lipids and increase the level of HDL, or good cholesterol, in the bloodstream. A cell-permeable, thiazolyl compound that acts as a potent, high affinity, PPARd agonist. Exhibits selectivity for PPARd compared t

Definition

ChEBI: An aromatic ether that is phenoxyacetic acid in which the phenyl group is substituted at position 2 by a methyl group and at position 4 by a (1,3-thiazol-5-ylmethyl)sulfanediyl group, and in which the 1,3-thiazolyl group is substituted at positions 2 and 4 by p-trifluoromethylphenyl and methyl groups, respectively.

General Description

GW501516 is the most selective and potent PPARβ (EC50=1.1nM) agonist that has been demonstrated to be 1,000-fold more selective in comparison to existing subtypes. It can regulate expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells and has been shown to block insulin resistance and fatty acid-induced nuclear factor-κB (NF-κB) activation.

Biological Activity

GW 501516 is a potent and selective PPARδ agonist (EC50 = 1.2 nM). Displays <1000-fold selectivity over other PPAR subtypes. Increases ABC A1 transporter expression and induces apolipoprotein A1-mediated cholesterol efflux in vitro. Also increase serum HDL cholesterol and lowers small, dense LDL levels in obesity in vivo models.

Biochem/physiol Actions

PPARδ activation by GW501516, retards weight gain through fatty acid catabolism in adipose tissue and skeletal muscles. GW501516 causes an increase in the levels high-density lipoprotein cholesterol and apolipoprotein A (apoA) and reduction in the low density-lipoprotein cholesterol, apoB, and triglyceride.

Mechanism of action

GW501516 is a selective agonist (activator) of the PPARδ receptor. It displays high affinity (Ki = 1 nM) and potency (EC50 = 1 nM) for PPARδ with > 1,000 fold selectivity over PPARα and PPARγ.In rats, binding of GW501516 to PPARδ recruits the coactivator PGC-1α. The PPARδ/coactivator complex in turn upregulates the expression of proteins involved in energy expenditure.[31] Furthermore, in rats treated with GW501516, increased fatty acid metabolism in skeletal muscle and protection against diet-induced obesity and type II diabetes was observed. In obese rhesus monkeys, GW501516 increased high-density lipoprotein (HDL) and lowered very-low-density lipoprotein (VLDL).

storage

Store at -20°C

References

[1] W. OLIVER. A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport[J]. Proceedings of the National Academy of Sciences of the United States of America, 2001, 26 1: 5306-5311. DOI:10.1073/pnas.091021198
[2] KEISUKE ITO. A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance[J]. Nature Medicine, 2012, 18 9: 1350-1358. DOI:10.1038/nm.2882
[3] EMMA BARROSO. The PPARβ/δ activator GW501516 prevents the down-regulation of AMPK caused by a high-fat diet in liver and amplifies the PGC-1α-Lipin 1-PPARα pathway leading to increased fatty acid oxidation.[J]. Endocrinology, 2011: 1848-1859. DOI:10.1210/en.2010-1468
[4] MIZUHO OKAZAKI. PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1.[J]. Endocrine journal, 2010, 57 5: 403-413. DOI:10.1507/endocrj.k10e-004
[5] VIHANG A NARKAR. AMPK and PPARdelta agonists are exercise mimetics.[J]. Journal of Chemical Theory and Computation, 2008: 405-415. DOI:10.1016/j.cell.2008.06.051

GW-501516 Preparation Products And Raw materials

Raw materials

Preparation Products

GW-501516 Suppliers

Global( 281)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Wolid Technology Co., Ltd. 		+447593789807 David@biopeplab.com China 48 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211 info@longyupharma.com China 2557 58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
+86-519-85525359 +86-15995072465 sales@xuanmingchem.com China 907 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 sales@sarms4muscle.com China 10473 58
Wuhan Kejiefeng Trading Co.,Ltd
+undefined18827003015 dong19981022@gmail.com China 178 58
Hebei Jiafan Trading Company Limited
+86-15354498258 sales01@jiafan88.com China 180 58
Shanghai Yimeixin Technology Co., LTD
China 195 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Firsky International Trade (Wuhan) Co., Ltd 		+8615387054039 admin@firsky-cn.com China 427 58
qingdao future trading Co., Ltd 		+86-13335044410 cui56813@163.com China 110 58
Supplier Advantage
Shenzhen Wolid Technology Co., Ltd. 		58
Shanghai Longyu Biotechnology Co., Ltd.
58
Changzhou Xuanming Pharmaceutical Technology Co., Ltd.
58
Zhejiang J&C Biological Technology Co.,Limited
58
Wuhan Kejiefeng Trading Co.,Ltd
58
Hebei Jiafan Trading Company Limited
58
Shanghai Yimeixin Technology Co., LTD
58
Hebei Yanxi Chemical Co., Ltd. 		58
Firsky International Trade (Wuhan) Co., Ltd 		58
qingdao future trading Co., Ltd 		58

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  • Sep 27，2023

View Lastest Price from GW-501516 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
GW-501516 pictures 2025-10-08 GW-501516
317318-70-0
 US $10.00 / ASSAYS 1ASSAYS 99% 1 ton RongNa Biotechnology Co.,Ltd
Cardarine;GW501516;GW1516 pictures 2025-10-08 Cardarine;GW501516;GW1516
317318-70-0
 US $30.00-10.00 / g 100g 99% 1000kg Shenzhen Aoxi Technology Co., Ltd.
GW-501516 pictures 2025-10-05 GW-501516
317318-70-0
 US $0.00-0.00 / g 10g 0.99 50t Wuhan Kejiefeng Trading Co.,Ltd
  • GW-501516 pictures
  • GW-501516
    317318-70-0
  • US $10.00 / ASSAYS
  • 99%
  • RongNa Biotechnology Co.,Ltd
  • GW-501516 pictures
  • GW-501516
    317318-70-0
  • US $0.00-0.00 / g
  • 0.99
  • Wuhan Kejiefeng Trading Co.,Ltd

GW-501516 Spectrum

GW-501516(317318-70-0)1HNMR

317318-70-0(GW-501516)Related Search:

PHENYL VALERATE Methyl methoxyacetate Acetoxyacetic acid Triphenyltin acetate Methoxyacetic acid
Diphenyldiethoxysilane Phenylhydrazine Diethoxymethyl acetate 4-Methoxyphenylacetone 4-Methoxyphenylacetic acid
2-Methyl-4-isothiazolin-3-one Daptomycin Tobramycin sulfate (2-METHYLPHENOXY)ACETIC ACID Sodelglitazar
Trifluoromethyl GW0742 GW-501516

1of4

2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid GW 501516, >=98% ENDUROBOL (GW-501516)/CARDARINE/ Cardarine(GW501516, GSK-516) GW-501615 2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a {2-Methyl-4-[4-Methyl-2-(4-trifluoroMethyl-phenyl)-thiazol-5-ylMethylsulfanyl]-phenoxy}-acetic acid Aceticacid, [2-Methyl-4-[[[4-Methyl-2-[4-(trifluoroMethyl)phenyl]-5-thiazolyl]Methyl]thio]phenoxy]-(9CI) GW 1516 ,GSK-516 {2-Methyl-4-{{4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl}methylthio}phenoxy}acetic acid CARDARINE ENDUROBOL GW501516(GSK-516) 2-(4-((2-(4-(TRIFLUOROMETHYL)PHENYL)-5-METHYLTHIAZOL-4-YL)METHYLTHIO)-2-METHYLPHENOXY)ACETIC ACID 2-[2-Methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]acetic Acid Methyl-methyl-trifluoromethylphenyl -thiazolyl-methylsulfanyl-phenoxy-acetic Acid 2-(4-((2-(4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid GW 1516 2-(2-methyl-4-((5-methyl-2-(4-(trifluoromethyl)phenyl)thiazol-4-yl)methylthio)phenoxy)acetic acid GW501516, Free Acid GSK-516 GW501516/GW1516/GW-1516/GW501516 GW-501516;GW 501516;GSK516;GSK 516 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic GW501516 (Cardarine) GW501516(GSK-516; GW1516) GW501516 White powder 99% GW501516 Mass Lean Fat Burning Steroids Sarms Bodybuilding Supplements White Powder Hot sale GW-501516 CAS NO.317318-70-0 CAS NO.317318-70-0 CS-788 (2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic acid GW501516(CARDARINE) ENDUROBOL GW501516 whnohe_lucy(at)163.com Endurobol，Cardarine GW-501516（Endurobol，Cardarine） hot sale high quality for GW-501516,4BB22 4bb22 powder with favorite price GW-501516,GW501516 Acetic acid, 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]methyl]thio]phenoxy]- 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)acetic acid USP/EP/BP GW1516 Cardarine Cardarine(GW501516,GSK-516) 99% purity Top Quality GW-501516 SARMS GW501516 Pharmaceutical Grade GW-501516 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)methylthio)-2-methylphenoxy)aceticaci GW501516 endurobol Cardarine(GW-501516 GW-501516(GSK-516,Cardarine) 2-(4-((2-(4-(Trifluoromethyl)phenyl)-5-methylthiazol-4-yl)me... GW501516 (Cardarine,GW)-1 gram(45) CARDAROL Cardrarine GW1516,GSK 516,GW-1516,GW-501516,Inhibitor,GW 501516,Peroxisome proliferator-activated receptors,PPAR,GSK516,inhibit,Autophagy ENDUROBOLGW501516 GW 501516（GW 1516 GW-501516?/?Cardarine 10mg Tablets GW 501516, 10 mM in DMSO GW501516 20mg