2-Methyl hydrogen pyridine-2,5-dicarboxylate
- CAS No.
- 17874-76-9
- Chemical Name:
- 2-Methyl hydrogen pyridine-2,5-dicarboxylate
- Synonyms
- 6-(METHOXYCARBONYL)NICOTINIC ACID;6-Methoxycarbonylpyridine-3-carboxylicaci;(Methoxycarbonyl)pyridine-3-carboxylic acid;2-Methyl hydrogen pyridine-2,5-dicarboxylate;2-Methylhydrogenpyridin-2,5-dicarboxylic acid;2,5-Pyridinedicarboxylic acid, 2-methyl ester;6-(Methoxycarbonyl)pyridine-3-carboxylic acid;5-Carboxy-2-(methoxycarbonyl)pyridine, 6-(Methoxycarbonyl)pyridine-3-carboxylic acid
- CBNumber:
- CB31486826
- Molecular Formula:
- C8H7NO4
- Molecular Weight:
- 181.15
- MDL Number:
- MFCD09702182
- MOL File:
- 17874-76-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
2-Methyl hydrogen pyridine-2,5-dicarboxylate price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR300619 | 6-(Methoxycarbonyl)nicotinic acid ≥95% | 17874-76-9 | 1g | $39 | 2026-06-04 | Buy |
| Apolloscientific | OR300619 | 6-(Methoxycarbonyl)nicotinic acid ≥95% | 17874-76-9 | 5g | $162 | 2026-06-04 | Buy |
| aablocks | AA00266Y | 6-(Methoxycarbonyl)pyridine-3-carboxylic Acid 97% | 17874-76-9 | 100mg | $7 | 2026-05-28 | Buy |
| aablocks | AA00266Y | 6-(Methoxycarbonyl)pyridine-3-carboxylic Acid 97% | 17874-76-9 | 250mg | $8 | 2026-05-28 | Buy |
| aablocks | AA00266Y | 6-(Methoxycarbonyl)pyridine-3-carboxylic Acid 97% | 17874-76-9 | 1g | $19 | 2026-05-28 | Buy |
2-Methyl hydrogen pyridine-2,5-dicarboxylate Chemical Properties, Uses, Production
Synthesis
67-56-1
100-26-5
17874-76-9
The general procedure for the synthesis of 6-(methoxycarbonyl)nicotinic acid from methanol and 2,5-dipyridinecarboxylic acid is as follows: with reference to the literature method 66, a selective esterification reaction was first carried out on 2,5-pyridinedicarboxylic acid (58). 58 was dissolved in methanol, a catalytic amount of sulfuric acid was added and the reaction was refluxed for 2 hours. Upon completion of the reaction, the monomethyl ester product (59) was purified by recrystallization from water in 42% yield. Subsequently, the monomethyl ester 59 was converted to the corresponding acyl chloride (60) by reflux reaction with an excess of thionyl chloride. Finally, the acylation of compound 35 was completed using the reflux reaction of the chloride 60 with an excess of aluminum trichloride in dichloromethane (DCM) (Scheme 10).
References
[1] Patent: WO2011/103321, 2011, A1. Location in patent: Page/Page column 23
[2] Patent: US2006/293319, 2006, A1. Location in patent: Page/Page column 47
[3] Patent: WO2007/70173, 2007, A2. Location in patent: Page/Page column 145-146
[4] European Journal of Inorganic Chemistry, 2010, # 13, p. 1913 - 1928
[5] Patent: WO2012/121973, 2012, A1. Location in patent: Page/Page column 89
2-Methyl hydrogen pyridine-2,5-dicarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| ChemCell Biomedicine Co.,Ltd. | 020-13556033878 2965585218 13556033878 | chemcell@hotmail.com | China | 369 | 52 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Shanghai Run-Biotech Co., Ltd. | 021-57171705 13817537615 | sales@run-biotech.com | China | 2277 | 58 |
