ChemicalBook >> CAS DataBase List >>tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate structure

CAS No.: 221050-88-0

Chemical Name:: tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

Synonyms: tert-Butyl 4-(2-chloropyrimidin-4-yl);2-Chloro-4-(4-Boc-1-piperazinyl)pyriMidine;1-Boc-4-(2-chloropyrimidin-4-yl)piperazine;2-Chloro-4-(4-BOC-piperazin-1-yl)pyrimidine;2-Chloro-4-[1-(4-tert-butoxycarbonyl)piperazinyl]pyrimidine;ert-butyl4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate;tert-Butyl 4-(2-Chloro-4-pyrimidinyl)-1-piperazinecarboxylate;tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate;4-(2-Chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 4-(2-chloro-4-pyrimidinyl)-, 1,1-dimethylethyl ester

CBNumber:: CB31501705

Molecular Formula:: C13H19ClN4O2

Molecular Weight:: 298.77

MDL Number:: MFCD03407443

MOL File:: 221050-88-0.mol

Last updated:2026-05-28 00:58:26

Product description	Number	Pack Size	Price
1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98%	OR902199	250mg	$21
1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98%	OR902199	1g	$24
1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98%	OR902199	5g	$63
1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98%	OR902199	25g	$255
1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98%	OR902199	100g	$966
More product size

Request For Quotation

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Properties

Boiling point	451.8±35.0 °C(Predicted)
Density	1.253±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	4.51±0.31(Predicted)
Appearance	White to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301-H315-H319-H335
Precautionary statements	P280-P305+P351+P338-P362+P364
HS Code	2933599590

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR902199	1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98%	221050-88-0	250mg	$21	2026-06-04	Buy
Apolloscientific	OR902199	1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98%	221050-88-0	1g	$24	2026-06-04	Buy
Apolloscientific	OR902199	1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98%	221050-88-0	5g	$63	2026-06-04	Buy
Apolloscientific	OR902199	1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98%	221050-88-0	25g	$255	2026-06-04	Buy
Apolloscientific	OR902199	1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98%	221050-88-0	100g	$966	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR902199	250mg	$21	Buy
OR902199	1g	$24	Buy
OR902199	5g	$63	Buy
OR902199	25g	$255	Buy
OR902199	100g	$966	Buy

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Chemical Properties,Uses,Production

Synthesis

3934-20-1

57260-71-6

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

221050-88-0

General procedure for the synthesis of 2-chloro-4-(4-BOC-1-piperazinyl)pyrimidine from 2,4-dichloropyrimidine and N-BOC-piperazine: 2,4-dichloropyrimidine (2.0 g, 13.43 mmol) was accurately weighed and dissolved in N,N-dimethylformamide (DMF) (15 mL), followed by the addition of triethylamine (TEA) (2.72 g, 26.85 mmol) and 1-Boc piperazine (2.75 g, 14.77 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction endpoint was confirmed by thin layer chromatography (TLC) monitoring. The reaction mixture was slowly poured into 200 mL of ice water, at which point a large amount of white solid precipitated. The white solid was collected by filtration and washed with an appropriate solvent and finally dried to afford the target product 2-chloro-4-(4-BOC-1-piperazinyl)pyrimidine (3.8 g, 13.43 mmol).

References

[1] Patent: CN108503645, 2018, A. Location in patent: Paragraph 0117-0119
[2] Patent: US2009/163508, 2009, A1. Location in patent: Page/Page column 14
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1468 - 1478
[4] Organic Letters, 2018, vol. 20, # 2, p. 473 - 476
[5] Patent: WO2017/58503, 2017, A1. Location in patent: Page/Page column 419; 421; 422

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

2,4-Dichloropyrimidine 1-BOC-Piperazine N,N-Dimethylformamide Triethylamine

Preparation Products

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Suppliers

Global( 79)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-173 9270 1263	1057@dideu.com	China	3959	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	9976	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30224	58
Sichuan Biosynce Pharmatech Co., Ltd.	+8619950309693	diane@biosynce.com	China	4871	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53803	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Shaanxi Dideu Medichem Co. Ltd	58
Fuxin Pharmaceutical	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
Career Henan Chemica Co	58
Sichuan Biosynce Pharmatech Co., Ltd.	58
Aladdin Scientific	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58

View Lastest Price from tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-05-17	1-Boc-4-(2-ChloropyriMidin-4-yl)piperazine 221050-88-0	$1.00	1KG	99%	20T	Shaanxi Dideu Medichem Co. Ltd

1-Boc-4-(2-ChloropyriMidin-4-yl)piperazine
221050-88-0
$1.00
99%
Shaanxi Dideu Medichem Co. Ltd

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Spectrum

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate(221050-88-0)¹HNMR

221050-88-0(tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate)Related Search:

Hydrochlorothiazide 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine 2-Chloro-4-(piperazin-1-yl)pyrimidine tert-Butyl 1-piperazinecarboxylate 2-CHLORO-N-ETHYL-N-METHYL-4-PYRIMIDINAMINE

N-Boc-N-methylethylenediamine tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

1of2

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate 2-Chloro-4-[1-(4-tert-butoxycarbonyl)piperazinyl]pyrimidine 4-(2-Chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester 1-Boc-4-(2-chloropyrimidin-4-yl)piperazine 2-Chloro-4-(4-Boc-1-piperazinyl)pyriMidine tert-Butyl 4-(2-Chloro-4-pyrimidinyl)-1-piperazinecarboxylate tert-Butyl 4-(2-chloropyrimidin-4-yl) 1-Piperazinecarboxylic acid, 4-(2-chloro-4-pyrimidinyl)-, 1,1-dimethylethyl ester ert-butyl4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate 2-Chloro-4-(4-BOC-piperazin-1-yl)pyrimidine 221050-88-0 pharmacetical