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tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Structure
tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate structure
CAS No.
221050-88-0
Chemical Name:
tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate
Synonyms
tert-Butyl 4-(2-chloropyrimidin-4-yl);2-Chloro-4-(4-Boc-1-piperazinyl)pyriMidine;1-Boc-4-(2-chloropyrimidin-4-yl)piperazine;2-Chloro-4-(4-BOC-piperazin-1-yl)pyrimidine;2-Chloro-4-[1-(4-tert-butoxycarbonyl)piperazinyl]pyrimidine;ert-butyl4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate;tert-Butyl 4-(2-Chloro-4-pyrimidinyl)-1-piperazinecarboxylate;tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate;4-(2-Chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 4-(2-chloro-4-pyrimidinyl)-, 1,1-dimethylethyl ester
CBNumber:
CB31501705
Molecular Formula:
C13H19ClN4O2
Molecular Weight:
298.77
MDL Number:
MFCD03407443
MOL File:
221050-88-0.mol
Last updated:2026-05-28 00:58:26
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tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Properties

Boiling point 451.8±35.0 °C(Predicted)
Density 1.253±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 4.51±0.31(Predicted)
Appearance White to yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P280-P305+P351+P338-P362+P364
HS Code  2933599590

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR902199 1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98% 221050-88-0 250mg $21 2026-06-04 Buy
Apolloscientific OR902199 1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98% 221050-88-0 1g $24 2026-06-04 Buy
Apolloscientific OR902199 1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98% 221050-88-0 5g $63 2026-06-04 Buy
Apolloscientific OR902199 1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98% 221050-88-0 25g $255 2026-06-04 Buy
Apolloscientific OR902199 1-Boc-4-(2-Chloropyrimidin-4-yl)piperazine >98% 221050-88-0 100g $966 2026-06-04 Buy
Product number Packaging Price Buy
OR902199 250mg $21 Buy
OR902199 1g $24 Buy
OR902199 5g $63 Buy
OR902199 25g $255 Buy
OR902199 100g $966 Buy

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Chemical Properties, Uses, Production

Synthesis

2,4-Dichloropyrimidine

3934-20-1

1-BOC-Piperazine

57260-71-6

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

221050-88-0

General procedure for the synthesis of 2-chloro-4-(4-BOC-1-piperazinyl)pyrimidine from 2,4-dichloropyrimidine and N-BOC-piperazine: 2,4-dichloropyrimidine (2.0 g, 13.43 mmol) was accurately weighed and dissolved in N,N-dimethylformamide (DMF) (15 mL), followed by the addition of triethylamine (TEA) (2.72 g, 26.85 mmol) and 1-Boc piperazine (2.75 g, 14.77 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction endpoint was confirmed by thin layer chromatography (TLC) monitoring. The reaction mixture was slowly poured into 200 mL of ice water, at which point a large amount of white solid precipitated. The white solid was collected by filtration and washed with an appropriate solvent and finally dried to afford the target product 2-chloro-4-(4-BOC-1-piperazinyl)pyrimidine (3.8 g, 13.43 mmol).

References

[1] Patent: CN108503645, 2018, A. Location in patent: Paragraph 0117-0119
[2] Patent: US2009/163508, 2009, A1. Location in patent: Page/Page column 14
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1468 - 1478
[4] Organic Letters, 2018, vol. 20, # 2, p. 473 - 476
[5] Patent: WO2017/58503, 2017, A1. Location in patent: Page/Page column 419; 421; 422

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Preparation Products And Raw materials

Raw materials

2,4-Dichloropyrimidine 1-BOC-Piperazine N,N-Dimethylformamide Triethylamine

Preparation Products

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Suppliers

Global Suppliers ( 77)
Supplier Tel Email Country ProdList Advantage
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 85114309 18982182443 yangli@happysyn.com China 2297 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai KenEn Chemical Technology Co., Ltd. 13120367189;18621755571 mychess007@163.com China 1994 55
Accela ChemBio Inc. +1(858) 699-3322 marketing@accelachem.com United States 6022 65
Chengdu J&B Technology Co., Ltd. 028-61186694 15608078506 609128801@qq.com China 853 55
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Supplier Advantage
Pure Chemistry Scientific Inc. 62
Accela ChemBio Co.,Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Nanjing Vital Chemical Co., Ltd. 65
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 55
Bide Pharmatech Ltd. 60
ShangHai KenEn Chemical Technology Co., Ltd. 55
Accela ChemBio Inc. 65
Chengdu J&B Technology Co., Ltd. 55
Amadis Chemical Company Limited 58

View Latest Price from tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Boc-4-(2-ChloropyriMidin-4-yl)piperazine pictures 2020-05-17 1-Boc-4-(2-ChloropyriMidin-4-yl)piperazine
221050-88-0
 $1.00 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Spectrum

tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate(221050-88-0)1HNMR

221050-88-0 (tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate) Related Search:

Hydrochlorothiazide 2-Chloro-N-ethyl-N-methyl-4-pyrimidinamine 2-Chloro-4-(4-methylpiperazin-1-yl)pyrimidine 2-Chloro-4-(piperazin-1-yl)pyrimidine tert-Butyl 1-piperazinecarboxylate
N-Boc-N-methylethylenediamine tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate

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tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate 2-Chloro-4-[1-(4-tert-butoxycarbonyl)piperazinyl]pyrimidine 4-(2-Chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester 1-Boc-4-(2-chloropyrimidin-4-yl)piperazine 2-Chloro-4-(4-Boc-1-piperazinyl)pyriMidine tert-Butyl 4-(2-Chloro-4-pyrimidinyl)-1-piperazinecarboxylate tert-Butyl 4-(2-chloropyrimidin-4-yl) 1-Piperazinecarboxylic acid, 4-(2-chloro-4-pyrimidinyl)-, 1,1-dimethylethyl ester ert-butyl4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate 2-Chloro-4-(4-BOC-piperazin-1-yl)pyrimidine 221050-88-0 pharmacetical