|
|
| | tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Basic information |
| Product Name: | tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate | | Synonyms: | tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate;2-Chloro-4-[1-(4-tert-butoxycarbonyl)piperazinyl]pyrimidine;4-(2-Chloropyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester;1-Boc-4-(2-chloropyrimidin-4-yl)piperazine;2-Chloro-4-(4-Boc-1-piperazinyl)pyriMidine;tert-Butyl 4-(2-Chloro-4-pyrimidinyl)-1-piperazinecarboxylate;tert-Butyl 4-(2-chloropyrimidin-4-yl);1-Piperazinecarboxylic acid, 4-(2-chloro-4-pyrimidinyl)-, 1,1-dimethylethyl ester | | CAS: | 221050-88-0 | | MF: | C13H19ClN4O2 | | MW: | 298.77 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 221050-88-0.mol |  |
| | tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Chemical Properties |
| Boiling point | 451.8±35.0 °C(Predicted) | | density | 1.253±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 4.51±0.31(Predicted) | | Appearance | White to yellow Solid |
| | tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-chloro-4-(4-BOC-1-piperazinyl)pyrimidine from 2,4-dichloropyrimidine and N-BOC-piperazine: 2,4-dichloropyrimidine (2.0 g, 13.43 mmol) was accurately weighed and dissolved in N,N-dimethylformamide (DMF) (15 mL), followed by the addition of triethylamine (TEA) (2.72 g, 26.85 mmol) and 1-Boc piperazine (2.75 g, 14.77 mmol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the reaction endpoint was confirmed by thin layer chromatography (TLC) monitoring. The reaction mixture was slowly poured into 200 mL of ice water, at which point a large amount of white solid precipitated. The white solid was collected by filtration and washed with an appropriate solvent and finally dried to afford the target product 2-chloro-4-(4-BOC-1-piperazinyl)pyrimidine (3.8 g, 13.43 mmol). | | References | [1] Patent: CN108503645, 2018, A. Location in patent: Paragraph 0117-0119
[2] Patent: US2009/163508, 2009, A1. Location in patent: Page/Page column 14
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 4, p. 1468 - 1478
[4] Organic Letters, 2018, vol. 20, # 2, p. 473 - 476
[5] Patent: WO2017/58503, 2017, A1. Location in patent: Page/Page column 419; 421; 422 |
| | tert-Butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate Preparation Products And Raw materials |
|