2-Chloro-6-aminopyrazine
- CAS No.
- 33332-28-4
- Chemical Name:
- 2-Chloro-6-aminopyrazine
- Synonyms
- 6-CHLOROPYRAZIN-2-AMINE;2-AMINO-6-CHLOROPYRAZINE;TIMTEC-BB SBB005488;6-chlorpyrazin-2-amin;6-Chloro-2-pyrazinaMine;2-chloro-6-aminopyrazine;6-Chloro-2-aMinopyrazine;6-AMino-2-chloropyrazine;2-PyrazinaMine, 6-chloro-;6-CHLOROPYRAZIN-2-YLAMINE
- CBNumber:
- CB3160912
- Molecular Formula:
- C4H4ClN3
- Molecular Weight:
- 129.55
- MDL Number:
- MFCD00055024
- MOL File:
- 33332-28-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 150-152°C |
|---|---|
| Boiling point | 282.8±35.0 °C(Predicted) |
| Density | 1.437±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Soluble in dimethyl sulfoxide and methanol. |
| form | Solid |
| pka | 0.89±0.10(Predicted) |
| color | Purple |
| InChI | InChI=1S/C4H4ClN3/c5-3-1-7-2-4(6)8-3/h1-2H,(H2,6,8) |
| InChIKey | JTPXVCKCLBROOJ-UHFFFAOYSA-N |
| SMILES | C1(N)=NC(Cl)=CN=C1 |
| LogP | 0.950 |
| CAS DataBase Reference | 33332-28-4(CAS DataBase Reference) |
| FDA UNII | CVL0CMW8XR |
| EPA Substance Registry System | 2-Amino-6-chloropyrazine (33332-28-4) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-22 | |||||||||
| Safety Statements | 26-36/37/39-60-37 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Chloro-6-aminopyrazine price More Price(86)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2145 | 2-Amino-6-chloropyrazine >98.0%(GC) | 33332-28-4 | 1g | $24 | 2026-04-30 | Buy |
| TCI Chemical | A2145 | 2-Amino-6-chloropyrazine >98.0%(GC) | 33332-28-4 | 5g | $79 | 2026-04-30 | Buy |
| AstaTech | 52698 | 6-CHLOROPYRAZIN-2-AMINE 97% | 33332-28-4 | 5G | $11 | 2026-04-30 | Buy |
| AstaTech | 52698 | 6-CHLOROPYRAZIN-2-AMINE 97% | 33332-28-4 | 25G | $29 | 2026-04-30 | Buy |
| AstaTech | 52698 | 6-CHLOROPYRAZIN-2-AMINE 97% | 33332-28-4 | 100G | $99 | 2026-04-30 | Buy |
2-Chloro-6-aminopyrazine Chemical Properties, Uses, Production
Chemical Properties
2-Chloro-6-aminopyrazine is Purple Solid
Uses
2-Chloro-6-aminopyrazine is a disubstituted pyrazine used in the preparation of A2B adenosine receptor antagonists and other biologically active compounds.
Uses
2-Amino-6-chloropyrazine is used in the preparation of A2B adenosine receptor antagonists and other biologically active compounds.
Synthesis
4774-14-5
33332-28-4
General procedure for the synthesis of 2-amino-6-chloropyrazine from 2,6-dichloropyrazine: 2,6-dichloropyrazine (10.0 g, 67.1 mmol) and ammonia (100 mL) were sequentially added to a hydrothermal reactor and reacted at 100 °C for 5 hours. After completion of the reaction, the reaction mixture was cooled to room temperature and the solid product was collected by filtration. The filter cake was pulped with hexane (16 mL) to give a final white solid of 8.2 g of 2-amino-6-chloropyrazine in 95.0% yield.
References
[1] Patent: CN107857737, 2018, A. Location in patent: Paragraph 0011-0013; 0021-0023; 0030-0032; 0040-0042; 0049
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 24, p. 8328 - 8342
[3] Patent: WO2013/68755, 2013, A1. Location in patent: Page/Page column 67, 68
[4] Patent: WO2017/5786, 2017, A1. Location in patent: Page/Page column 23; 24
[5] Tetrahedron, 1984, vol. 40, # 24, p. 5081 - 5088
2-Chloro-6-aminopyrazine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Xinrui Biotechnology Co., Ltd. | 13401437572 | xinruibiotech01@163.com | China | 2738 | 58 |
| Shanghai ChemIDo Co., Ltd. | 19301251526 | sales@chemido.com | China | 69 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 2-Chloro-6-aminopyrazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Chloro-6-aminopyrazine
33332-28-4
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2024-03-27 | 2-Amino-6-chloropyrazine
33332-28-4
|
$650.00 | 1Kg | 98 | 500 Kg | R&D Scientific Inc. | |
 |
2021-10-14 | 2-Chloro-6-aminopyrazine Basic information
33332-28-4
|
$10.00 | 1Kg/Bag | 99% | 20 Tons | Hebei Zhanyao Biotechnology Co. Ltd |
-
- 2-Chloro-6-aminopyrazine
33332-28-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Amino-6-chloropyrazine
33332-28-4
- $650.00
- 98
- R&D Scientific Inc.
-
- 2-Chloro-6-aminopyrazine Basic information
33332-28-4
- $10.00
- 99%
- Hebei Zhanyao Biotechnology Co. Ltd
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