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2,6-Dichloropyrazine

2,6-Dichloropyrazine structure

CAS No.: 4774-14-5

Chemical Name:: 2,6-Dichloropyrazine

Synonyms: M-Dichloropyrazine;6-Dichloropyrazine;2,6-Dichlor-pyrazin;2,6-CHLORO PYRAZINE;2,6-DICHLOROPYRAZINE;2,6-dichloro-pyrazin;2,6-Dichloropyrazine>Pyrazine, 2,6-dichloro-;2,6-Dichloro-1,4-diazine;2,6-Dichloropyrazine,99%

CBNumber:: CB3414088

Molecular Formula:: C4H2Cl2N2

Molecular Weight:: 148.98

MDL Number:: MFCD00006125

MOL File:: 4774-14-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 06:28:38

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2,6-Dichloropyrazine Properties

Melting point	55-58 °C (lit.)
Boiling point	122 °C / 40mmHg
Density	1.6445 (rough estimate)
refractive index	1.6300 (estimate)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in ethanol and methanol.
form	Crystals or Crystalline Powder
pka	-3.11±0.10(Predicted)
color	White to beige
BRN	2439
InChI	1S/C4H2Cl2N2/c5-3-1-7-2-4(6)8-3/h1-2H
InChIKey	LSEAAPGIZCDEEH-UHFFFAOYSA-N
SMILES	Clc1cncc(Cl)n1
LogP	1.530
CAS DataBase Reference	4774-14-5(CAS DataBase Reference)
FDA UNII	2NX2PQ9HSL
NIST Chemistry Reference	2,6-Dichloropyrazine(4774-14-5)
EPA Substance Registry System	2,6-Dichloropyrazine (4774-14-5)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-20/21/22

Safety Statements

26-37/39-36/37/39-22-36

WGK Germany

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29339990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

2,6-Dichloropyrazine price More Price(90)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	132497	2,6-Dichloropyrazine 98%	4774-14-5	5g	$50	2023-06-20	Buy
TCI Chemical	D1867	2,6-Dichloropyrazine >99.0%(GC)	4774-14-5	5g	$28	2026-04-30	Buy
TCI Chemical	D1867	2,6-Dichloropyrazine >99.0%(GC)	4774-14-5	25g	$81	2026-04-30	Buy
Usbiological	D3532-55	2,6-Dichloropyrazine (2,6-Dichlor-pyrazin)	4774-14-5	10g	$319	2026-06-03	Buy
TRC	TRC-D435825-250G	2,6-Dichloropyrazine	4774-14-5	250g	$137	2026-06-03	Buy

Product number	Packaging	Price	Buy
132497	5g	$50	Buy
D1867	5g	$28	Buy
D1867	25g	$81	Buy
D3532-55	10g	$319	Buy
TRC-D435825-250G	250g	$137	Buy

2,6-Dichloropyrazine Chemical Properties, Uses, Production

Chemical Properties

White Powder

Uses

2,6-Dichloropyrazine is used in the preparation of pyrazine and pyridine compounds as ATR kinase inhibitors. It is also used in the synthesis of oxacalixarenes containing nitrogen heterocycles.

Synthesis

The production method of 2,6-dichloropyrazine comprises the following steps: carrying out ammoniation and cyclization reactions of raw materials comprising methyl chloroacetate, glyoxal and the like to prepare 2-hydroxypyrazine sodium, reacting 2-hydroxypyrazine sodium with phosphorous oxychloride under the catalysis action of N,N-dimethylaminopyridine to prepare 2-chloropyrazine, and chlorinating 2-chloropyrazine by chlorine under the catalysis action of triethylamine with dimethyl formamide as a solvent to prepare 2,6-dichloropyrazine.

2,6-Dichloropyrazine Preparation Products And Raw materials

Raw materials

Glyoxal

Preparation Products

2-chloro-6-ethoxypyrazine 3,5-Dichloropyrazine-2-carboxamide 2-Chloro-6-methoxypyrazine 2,6-Dimethoxypyrazine 2-Chloro-6-(3-fluorophenoxy) pyrazine

Imidazo[1,2-a]pyridine, 3-(6-chloro-2-pyrazinyl)- 6-(chloropyrazin-2-yl)phenylamine Pyrazine, 2-chloro-6-(tributylstannyl)- 2-chloro-6-(cyclohexyloxy)pyrazine 2-chloro-6-(4-chlorophenyl)pyrazine

2-chloro-6-(1-piperazinyl)pyrazine monohydrochloride 2-PyrazinaMine, 6-chloro-N-[1-(1,1-diMethylethyl)-1H-pyrazol-5-yl]-

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2,6-Dichloropyrazine Suppliers

Global Suppliers ( 455)

Supplier	Tel	Email	Country	ProdList	Advantage
Zhongxin Chenshi (Wuhan) Technology Co., Ltd	18942922096	2662561040@qq.com	China	980	58
Zhongxiang Yaowei Biological Technology Co., Ltd.	15337241005 13260682861;15337241005	w13260682861@qq.com	China	2335	58
Zhejiang Sunrise Pharmaceutical Co. LTD	18257189358	lorraine@sfcc.com	China	20	58
Wuhan Tongyi Su Biotechnology Co., Ltd.	15071019375	634847344@qq.com	China	876	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61

Supplier	Advantage
Zhongxin Chenshi (Wuhan) Technology Co., Ltd	58
Zhongxiang Yaowei Biological Technology Co., Ltd.	58
Zhejiang Sunrise Pharmaceutical Co. LTD	58
Wuhan Tongyi Su Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61

View Latest Price from 2,6-Dichloropyrazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	2,6-Dichloropyrazine 4774-14-5	$66.00-99.00		99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-04-27	2,6-Dichloropyrazine 4774-14-5		1kg	98%	100tons	Shandong Vital Biotechnology Co., Ltd.
2026-04-10	2,6-Dichloropyrazine 4774-14-5	$2.00-5.00	1KG	99% hplc	500TONS	Wuhan JiyunZen Tech Co., Ltd.

2,6-Dichloropyrazine
4774-14-5
$66.00-99.00
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

2,6-Dichloropyrazine
4774-14-5
98%
Shandong Vital Biotechnology Co., Ltd.

2,6-Dichloropyrazine
4774-14-5
$2.00-5.00
99% hplc
Wuhan JiyunZen Tech Co., Ltd.

2,6-Dichloropyrazine Spectrum

2,6-Dichloropyrazine(4774-14-5)MS 2,6-Dichloropyrazine(4774-14-5)¹HNMR 2,6-Dichloropyrazine(4774-14-5)¹³CNMR 2,6-Dichloropyrazine(4774-14-5)IR1 2,6-Dichloropyrazine(4774-14-5)IR2 2,6-Dichloropyrazine(4774-14-5)Raman

4774-14-5 (2,6-Dichloropyrazine) Related Search:

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6-(Trifluoromethyl)nicotinic acid 2,5-DICHLOROPYRAZINE 2-Chloropyrazine Pyrazine 2-Amino-3,5-dichloropyrazine

3,5-dichloropyrazine-2-carbaldehyde 3,5-Dichloropyrazine-2-carboxyamide 2,6-Dichloropyrazine 3,5,6-Trichloro-N-methylpyrazin-2-amine 2,6-Dichloro-3-(tributylstannyl)pyrazine

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2,6-dichloro-pyrazin Pyrazine, 2,6-dichloro- 2,6-Dichloropyrazine,99% 2,6-Dichlor-pyrazin 6-Dichloropyrazine M-Dichloropyrazine 2,6-Dichloro-1,4-diazine 2,6-DICHLOROPYRAZINE 2,6-CHLORO PYRAZINE 2,6-Dichloropyrazine> 2,6-Dichloropyrazine USP/EP/BP 2,6-Dichloropyrazine, 97% 2,6-Dichloropyrazine，97% min 4774-14-5 C4H2CI2N2 Halogenated Heterocycles Heterocyclic Building Blocks Chloropyrazines, etc. Pyrazines Building Blocks alkyl chloride Building Blocks Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks Pesticides intermediate Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrazinesHeterocyclic Building Blocks Heterocyclic Compounds Pyrazines Chloropyrazines, etc. Heterocycles Pyrazines, Pyrimidines & Pyridazines API intermediates Halides Pyrazines, Pyrimidines & Pyridazines bc0001