(+/-)12-HETE
- CAS No.
- 71030-37-0
- Chemical Name:
- (+/-)12-HETE
- Synonyms
- (R)-12-HETE;(+/-)12-HETE;12-HETE (Standard);ZNHVWPKMFKADKW-VXBMJZGYSA-N;12-hydroxyeicosatetraenoicacid;(5Z,8Z,10E,14Z)-12-hydroxyicosatetraenoic acid;10,14-eicosatetraenoicacid,12-hydroxy-,(e,z,z,z)-8;(+/-)12-HYDROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID;(+/-)12-HYDROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID;5,8,10,14-Eicosatetraenoic acid, 12-hydroxy-, (E,Z,Z,Z)-
- CBNumber:
- CB3176331
- Molecular Formula:
- C20H32O3
- Molecular Weight:
- 320.47
- MDL Number:
- MFCD00065826
- MOL File:
- 71030-37-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 487.7±45.0 °C(Predicted) |
|---|---|
| Density | 0.984±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml |
| form | Liquid |
| pka | 4.75±0.10(Predicted) |
| color | Colorless to light yellow |
| EWG's Food Scores | 1 |
| FDA UNII | Q6F9H3VPC0 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| NFPA 704 |
|
(+/-)12-HETE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 34550 | (±)12-HETE ≥95% | 71030-37-0 | 25μg | $87 | 2026-04-30 | Buy |
| Cayman Chemical | 34550 | (±)12-HETE ≥95% | 71030-37-0 | 50μg | $165 | 2026-04-30 | Buy |
| Cayman Chemical | 34550 | (±)12-HETE ≥95% | 71030-37-0 | 100μg | $313 | 2026-04-30 | Buy |
| Cayman Chemical | 34550 | (±)12-HETE ≥95% | 71030-37-0 | 250μg | $653 | 2026-04-30 | Buy |
| Biosynth | WCA03037 | 12-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic acid, 100ug/ml in ethanol | 71030-37-0 | 0.1mg | $1194.16 | 2026-06-05 | Buy |
(+/-)12-HETE Chemical Properties, Uses, Production
Description
(±)12-
Uses
12-HETE, a major metabolic product of arachidonic acid using 12-LOX catalysis, inhibits cell apoptosis in a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation of NF-κB through the integrin-linked kinase (ILK) pathway[1].12-HETE has both anti-thrombotic and pro-thrombotic effects[2]. 12-HETE is a neuromodulator[3].
Definition
ChEBI: (5Z,8Z,10E,14Z)-12-hydroxyicosatetraenoic acid is the (5Z,8Z,10E,14Z)-stereoisomer of 12-HETE. It has a role as a mouse metabolite. It is a conjugate acid of a 12-HETE(1-).
References
[1] Qian Liu, et al. 12-HETE facilitates cell survival by activating the integrin-linked kinase/NF-κB pathway in ovarian cancer. Cancer Manag Res. 2018 Nov 16;10:5825-5838. DOI:10.2147/CMAR.S180334
[2] Benedetta Porro, et al. Analysis, physiological and clinical significance of 12-HETE: a neglected platelet-derived 12-lipoxygenase product. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Aug 1;964:26-40. DOI:10.1016/j.jchromb.2014.03.015
[3] Aidan J Hampson, et al. 12-hydroxyeicosatetrenoate (12-HETE) attenuates AMPA receptor-mediated neurotoxicity: evidence for a G-protein-coupled HETE receptor. J Neurosci. 2002 Jan 1;22(1):257-64. DOI:10.1523/JNEUROSCI.22-01-00257.2002
(+/-)12-HETE Preparation Products And Raw materials
Raw materials
Preparation Products
(+/-)12-HETE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1978 | 58 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9170 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 18916372613 | yanzihan@shyuanye.com | China | 87240 | 60 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55055611 18137792234 | 3957071458@qq.com | China | 9941 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
