Ethyl acetimidate hydrochloride
- CAS No.
- 2208-07-3
- Chemical Name:
- Ethyl acetimidate hydrochloride
- Synonyms
- Ethanimidic acid, ethyl ester;EAH;ethyl ethanimidate;Ethyl ethanimidoate;ethyl ethanecarboximidate hydrochloride;Ethanimidic acid, ethyl ester, hydrochloride (1:1);Ehtyl acetimidate;1-Ethoxyethanimine;EthyliminoacetateHCl;acetimidate hydrochL
- CBNumber:
- CB3182189
- Molecular Formula:
- C4H10ClNO
- Molecular Weight:
- 123.58
- MDL Number:
- MFCD00012572
- MOL File:
- 2208-07-3.mol
- MSDS File:
- SDS
| Melting point | 112-114 °C(lit.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | water: soluble50mg/mL, clear, colorless |
| form | Crystalline Powder |
| color | White |
| Water Solubility | Soluble in water (50mg/L). |
| Sensitive | Moisture Sensitive |
| BRN | 3552401 |
| Stability | Hygroscopic, Moisture Sensitive |
| InChI | InChI=1S/C4H9NO.ClH/c1-3-6-4(2)5;/h5H,3H2,1-2H3;1H |
| InChIKey | WGMHMVLZFAJNOT-UHFFFAOYSA-N |
| SMILES | O(CC)C(=N)C.Cl |
| CAS DataBase Reference | 2208-07-3(CAS DataBase Reference) |
| EPA Substance Registry System | Ethanimidic acid, ethyl ester, hydrochloride (2208-07-3) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10-21 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29252900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Ethyl acetimidate hydrochloride price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 188840 | Ethyl acetimidate hydrochloride 97% | 2208-07-3 | 10g | $43.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 188840 | Ethyl acetimidate hydrochloride 97% | 2208-07-3 | 50g | $85.2 | 2026-04-30 | Buy |
| Apolloscientific | OR903066 | Ethyl acetimidate hydrochloride 95% | 2208-07-3 | 100g | $98 | 2026-06-04 | Buy |
| Apolloscientific | OR903066 | Ethyl acetimidate hydrochloride 95% | 2208-07-3 | 500g | $321 | 2026-06-04 | Buy |
| AK Scientific | M406 | Ethyl acetimidate hydrochloride 97%(HPLC) | 2208-07-3 | 5g | $16 | 2026-06-04 | Buy |
Ethyl acetimidate hydrochloride Chemical Properties, Uses, Production
Chemical Properties
white to light yellow crystal powder
Uses
Ethyl acetimidate hydrochloride was used in preparation of amidinated carbonic anhydrase via chemical modification of human erythrocyte carbonic anhydrase. It was also used in synthesis of methyl 2-methyl-2-thiazoline-4-carboxylate hydrochloride.
Synthesis
64-17-5
75-05-8
2208-07-3
2) Example 1-2: Preparation of ethyl acetimidate hydrochloride 1.6 kg of acetonitrile and 4.3 kg of ethanol were added to the reactor and the reactor was cooled to -10°C. 3.67 kg of acetyl chloride was slowly added under stirring and the reaction mixture was kept stirred at 0°C for 12 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure at 45°C. To the residue was added 11.8 kg of tert-butyl methyl ether and stirred at room temperature for 3 hours. The precipitated solid was collected by filtration and dried under vacuum at 40 °C to give 4.58 kg ethyl acetimidate hydrochloride (yield: 95%). Product characterization data: 1H-NMR (400 MHz, DMSO-d6) δ: 11.7 (s, 2H), 4.26 (q, 2H), 2.38 (s, 3H), 1.36 (t, 3H).
Purification Methods
Recrystallise the hydrochloride by dissolving it in the minimum volume of super dry EtOH and adding dry Et2O or from dry Et2O. Dry it in a vacuum and store it in a vacuum desiccator with P2O5. Alternatively it could be crystallised from EtOH (containing a couple of drops of ethanolic HCl) and adding dry Et2O. Filter and dry it in a vacuum desiccator over H2SO4 and NaOH. [Pinner Chem Ber 16 1654 1883, Glickman & Cope J Am Chem Soc 67 1020 1945, Chaplin & Hunter J Chem Soc 1118 1937, McElvain & Schroeder J Am Chem Soc 71 40 1949, McElvain & Tate J Am Chem Soc 73 2233 1951, Methods Enzymol 25 585 1972, Beilstein 2 III 418.]
References
[1] Combinatorial Chemistry and High Throughput Screening, 2011, vol. 14, # 2, p. 132 - 137
[2] Patent: WO2015/5615, 2015, A1. Location in patent: Paragraph 142; 143; 144
[3] New Journal of Chemistry, 2018, vol. 42, # 16, p. 13367 - 13374
[4] Journal of Medicinal Chemistry, 2004, vol. 47, # 4, p. 915 - 927
[5] Chemische Berichte, 1985, vol. 118, # 8, p. 3089 - 3104
Ethyl acetimidate hydrochloride Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Olefin Pharmaceutical Co., Ltd. | 18202662021 18522876413 | 2781212171@qq.com | China | 313 | 56 |
| Tianjin Ruide Famo Technology Co., Ltd | 13821803402 | RD_PHARM@163.com | China | 842 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| future industrial shanghai co., ltd | 400-0066400 13621662912 | sales@jonln.com | China | 1989 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
View Latest Price from Ethyl acetimidate hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | Ethyl acetimidate hydrochloride
2208-07-3
|
$8.00 | 1kg | 99% | 10TON | Career Henan Chemical Co |
-
- Ethyl acetimidate hydrochloride
2208-07-3
- $8.00
- 99%
- Career Henan Chemical Co
