3-Cyclobutyl-3-oxo-propionic acid ethyl ester
- CAS No.
- 24922-01-8
- Chemical Name:
- 3-Cyclobutyl-3-oxo-propionic acid ethyl ester
- Synonyms
- ETHYL 3-CYCLOBUTYL-3-OXOPROPANOATE;3-Cyclobutyl-3-oxo-propionic acid ethyl ester;CYCLOBUTANEPROPANOICACID, B-OXO-, ETHYL ESTER;Cyclobutanepropanoic acid, β-oxo-, ethyl ester
- CBNumber:
- CB3191246
- Molecular Formula:
- C9H14O3
- Molecular Weight:
- 170.21
- MDL Number:
- MFCD06410651
- MOL File:
- 24922-01-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H315 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 |
| HS Code | 2918999090 |
3-Cyclobutyl-3-oxo-propionic acid ethyl ester price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | ZAA92201 | Ethyl 3-cyclobutyl-3-oxopropanoate | 24922-01-8 | 10g | $354 | 2026-06-05 | Buy |
| Biosynth | ZAA92201 | Ethyl 3-cyclobutyl-3-oxopropanoate | 24922-01-8 | 100g | $2360 | 2026-06-05 | Buy |
| Apolloscientific | OR451071 | Ethyl 3-cyclobutyl-3-oxopropanoate 98% | 24922-01-8 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR451071 | Ethyl 3-cyclobutyl-3-oxopropanoate 98% | 24922-01-8 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR451071 | Ethyl 3-cyclobutyl-3-oxopropanoate 98% | 24922-01-8 | 5g | $82 | 2026-06-04 | Buy |
3-Cyclobutyl-3-oxo-propionic acid ethyl ester Chemical Properties, Uses, Production
Synthesis
6148-64-7
5006-22-4
24922-01-8
The general procedure for the synthesis of ethyl 3-cyclobutyl-3-oxopropanoate from monoethyl malonate potassium salt and cyclobutanecarbonyl chloride was as follows: potassium 3-ethoxy-3-oxopropanoate (60.3 g, 354.25 mmol) was suspended in acetonitrile (600 mL) under the protection of argon gas and cooled to 10 °C. Subsequently, triethylamine (75 mL, 540 mmol) and magnesium chloride (40.2 g, 421.72 mmol) were added sequentially, and the reaction temperature was controlled not to exceed 25 °C. The resulting thick white suspension was stirred at room temperature for 2.5 hours in an argon atmosphere. After that, the reaction mixture was cooled to 0-5 °C again and cyclobutanecarbonyl chloride (19.25 mL, 167 mmol) was added slowly dropwise for a controlled period of 1 hour. After the dropwise addition, the reaction mixture was allowed to gradually warm up to room temperature and continued stirring for 18 hours. After completion of the reaction, the solvent was removed by evaporation. The residue was dissolved in ethyl acetate (700 mL) and adjusted to an aqueous phase pH=5 with 2M hydrochloric acid (~400 mL) to ensure that all substances were dissolved. The organic phase was separated and washed sequentially with 2M hydrochloric acid (200 mL), saturated aqueous sodium bicarbonate (2 x 200 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to afford ethyl 3-cyclobutyl-3-oxopropionate as a light yellow oil (28.0 g, 98% yield). The structure of the product was confirmed by 1H NMR (400.132 MHz, CDCl3): δ 1.28 (3H, t), 1.80-1.89 (1H, m), 1.91-2.05 (1H, m), 2.12-2.34 (4H, m), 3.39 (2H, s), 3.34-3.42 (1H, m), 4.19 (2H, q).
References
[1] Patent: WO2011/114148, 2011, A1. Location in patent: Page/Page column 81
3-Cyclobutyl-3-oxo-propionic acid ethyl ester Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Sci General Material & Chemical Ltd | 021-58388037;21-58388037 13472507714 | 35177634@qq.com;1589045147@qq.com | China | 795 | 55 |
| Shanghai civi chemical technology co.,Ltd | 86-21-34053660 | sale@labgogo.com | China | 9853 | 52 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| Abblis Chemicals LLC | +1-832-373-8299 | info@abblis.com | United States | 322 | 57 |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 3-Cyclobutyl-3-oxo-propionic acid ethyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-13 | 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER
24922-01-8
|
1KG | 98%; 99% | 500g； 1kg; 25kg | Career Henan Chemical Co | ||
 |
2019-12-23 | 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER
24922-01-8
|
$1.00 | 1g | 99% | 1000KGS | Career Henan Chemical Co |
-
- 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER
24922-01-8
- $0.01
- 98%; 99%
- Career Henan Chemical Co
-
- 3-CYCLOBUTYL-3-OXO-PROPIONIC ACID ETHYL ESTER
24922-01-8
- $1.00
- 99%
- Career Henan Chemical Co
