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4-Chloro-3-fluorobenzaldehyde

4-Chloro-3-fluorobenzaldehyde Structure
4-Chloro-3-fluorobenzaldehyde structure
CAS No.
5527-95-7
Chemical Name:
4-Chloro-3-fluorobenzaldehyde
Synonyms
NORF-001;TIMTEC-BB SBB003986;Fluoro-4-chlorobenzaldehyde;3-Bromo-8-fluoroacetophenone;3-FLUORO-4-CHLOROBENZALDEHYDE;4-CHLORO-3-FLUOROBENZALDEHYDE;4-Chloro-3-fluorobenzaldehyde98%;Benzaldehyde, 4-chloro-3-fluoro-;4-Chloro-3-fluorobenzaldehyde >4-Chloro-3-fluorobenzaldehyde 98%
CBNumber:
CB3197031
Molecular Formula:
C7H4ClFO
Molecular Weight:
158.56
MDL Number:
MFCD00143288
MOL File:
5527-95-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 01:02:13
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4-Chloro-3-fluorobenzaldehyde Properties

Melting point 46-49 °C (lit.)
Boiling point 201.5°C (rough estimate)
Density 1.3310 (estimate)
Flash point 206 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Solid
color White to yellow
Water Solubility Insoluble
Sensitive Air Sensitive
InChI InChI=1S/C7H4ClFO/c8-6-2-1-5(4-10)3-7(6)9/h1-4H
InChIKey AZMDWRPTDCIFRD-UHFFFAOYSA-N
SMILES C(=O)C1=CC=C(Cl)C(F)=C1
CAS DataBase Reference 5527-95-7(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn,T
Risk Statements  36/37/38-22-23/24/25
Safety Statements  26-36-36/37/39-45
WGK Germany  3
HazardClass  IRRITANT
HS Code  29124990
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4-Chloro-3-fluorobenzaldehyde price More Price(69)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 537241 4-Chloro-3-Fluorobenzaldehyde 97% 5527-95-7 5g $159 2023-06-20 Buy
TCI Chemical C1506 4-Chloro-3-fluorobenzaldehyde >97.0%(GC) 5527-95-7 1g $44 2026-04-30 Buy
TCI Chemical C1506 4-Chloro-3-fluorobenzaldehyde >97.0%(GC) 5527-95-7 5g $148 2026-04-30 Buy
Usbiological 267498 4-Chloro-3-fluorobenzaldehyde Asreported 5527-95-7 250g $2141 2026-06-03 Buy
Usbiological 267498 4-Chloro-3-fluorobenzaldehyde Asreported 5527-95-7 500g $3398 2026-06-03 Buy
Product number Packaging Price Buy
537241 5g $159 Buy
C1506 1g $44 Buy
C1506 5g $148 Buy
267498 250g $2141 Buy
267498 500g $3398 Buy

4-Chloro-3-fluorobenzaldehyde Chemical Properties, Uses, Production

Synthesis

Synthesis of 5527-95-7

The reaction was carried out in an 80 mL Teflon-lined stainless steel reactor equipped with a magnetic stir bar. 4-Chloro-3-fluoroiodobenzene (1.0 mmol), rhodium(III) chloride hydrate (0.025 mmol), PPh3 (0.1 mmol), Et3N (1.2 mmol), and N,N-dimethylacetamide (2 mL) were added to the reactor in a glove box. The autoclave was tightened. CO and H2 were injected into the autoclave to bring the total pressure to 10 bar (1:1). The mixture was transferred to an oil bath preheated at 90°C for 12 hours. The reaction was controlled using a Haake-D3 temperature controller. After the reaction was complete, the reactor was cooled in ice water. The atmosphere was carefully vented.

Add 5 mL of CH₂Cl₂ to the reaction mixture. Add 10 mL of deionized water to the mixture and extract five times with the solvent N,N-dimethylacetamide. Dry the organic layer with anhydrous Na₂SO₄. Concentrate the organic layer by rotary evaporation. Purify the product by silica gel column chromatography using n-hexane/ethyl acetate as eluent.

Chemical Properties

white to light yellow crystal powder

Uses

4-Chloro-3-fluorobenzaldehyde is an organic intermediate that can be prepared from 4-chloro-3-fluoroiodobenzene in one step. It has been reported in the literature that it can be used to prepare piperidine derivatives.

4-Chloro-3-fluorobenzaldehyde synthesis

201230-82-2
202982-67-0
5527-95-7
Synthesis of 4-Chloro-3-fluorobenzaldehyde from carbon monoxide and 4-Chloro-3-fluoroiodobenzene

4-Chloro-3-fluorobenzaldehyde Preparation Products And Raw materials

Raw materials

4-Chloro-3-fluoroiodobenzene

Preparation Products

1H-Indole, 6-chloro-7-fluoro- 4-Chloro-3-fluorocinnamic acid 2-amino-1-(4-chloro-3-fluorophenyl)ethan-1-ol

4-Chloro-3-fluorobenzaldehyde Suppliers

Global Suppliers ( 317)
Supplier Tel Email Country ProdList Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Jiangsu Jingping New Material Technology Co., Ltd. 18852320356 3437818551@qq.com China 81 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Supplier Advantage
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Shanghai Longsheng chemical Co.,Ltd. 59
Jiangsu Jingping New Material Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66

View Latest Price from 4-Chloro-3-fluorobenzaldehyde manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-3-fluorobenzaldehyde pictures 2026-03-20 4-Chloro-3-fluorobenzaldehyde
5527-95-7
 1KG 99% 20 mt Hebei Chuanghai Biotechnology Co., Ltd
4-Chloro-3-fluorobenzaldehyde pictures 2021-07-13 4-Chloro-3-fluorobenzaldehyde
5527-95-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd
4-Chloro-3-fluorobenzaldehyde pictures 2021-07-10 4-Chloro-3-fluorobenzaldehyde
5527-95-7
 $10.00-15.00 1KG 99%+ HPLC Zhuozhou Wenxi import and Export Co., Ltd

4-Chloro-3-fluorobenzaldehyde Spectrum

4-Chloro-3-fluorobenzaldehyde(5527-95-7)MS4-Chloro-3-fluorobenzaldehyde(5527-95-7)1HNMR4-Chloro-3-fluorobenzaldehyde(5527-95-7)13CNMR4-Chloro-3-fluorobenzaldehyde(5527-95-7)IR14-Chloro-3-fluorobenzaldehyde(5527-95-7)IR2

5527-95-7 (4-Chloro-3-fluorobenzaldehyde) Related Search:

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4-CHLORO-3-FLUOROBENZALDEHYDE 3-FLUORO-4-CHLOROBENZALDEHYDE TIMTEC-BB SBB003986 4-Chloro-3-fluorobenzaldehyde, 98% 5GR 4-Chloro-3-fluorobenzaldehyde 98% 4-Chloro-3-fluorobenzaldehyde98% Fluoro-4-chlorobenzaldehyde NORF-001 4-Chloro-3-fluorobenzaldehyde > Benzaldehyde, 4-chloro-3-fluoro- 4-Chloro-3-fluorobenzaldehyde ISO 9001：2015 REACH 3-Fluoro-4-chlorobenzaldehyde3-Fluoro-4-chlorobenzaldehyde 3-Bromo-8-fluoroacetophenone 5527-95-7 118-16-7 Organic Building Blocks Aldehydes ALDEHYDE Building Blocks Carbonyl Compounds C7 Fluorine series Fluorin-contained benzaldehyde series Aromatic Aldehydes & Derivatives (substituted) Benzaldehyde Adehydes, Acetals & Ketones Chlorine Compounds Fluorine Compounds Aldehydes C7 Carbonyl Compounds