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| | 4-Chloro-3-fluorobenzaldehyde Basic information | | Synthesis |
| | 4-Chloro-3-fluorobenzaldehyde Chemical Properties |
| Melting point | 46-49 °C (lit.) | | Boiling point | 201.5°C (rough estimate) | | density | 1.3310 (estimate) | | Fp | 206 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Solid | | color | White to yellow | | Water Solubility | Insoluble | | Sensitive | Air Sensitive | | InChI | InChI=1S/C7H4ClFO/c8-6-2-1-5(4-10)3-7(6)9/h1-4H | | InChIKey | AZMDWRPTDCIFRD-UHFFFAOYSA-N | | SMILES | C(=O)C1=CC=C(Cl)C(F)=C1 | | CAS DataBase Reference | 5527-95-7(CAS DataBase Reference) |
| Hazard Codes | Xi,Xn,T | | Risk Statements | 36/37/38-22-23/24/25 | | Safety Statements | 26-36-36/37/39-45 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29124990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 4-Chloro-3-fluorobenzaldehyde Usage And Synthesis |
| Synthesis | 
The reaction was carried out in an 80 mL Teflon-lined stainless steel reactor equipped with a magnetic stir bar. 4-Chloro-3-fluoroiodobenzene (1.0 mmol), rhodium(III) chloride hydrate (0.025 mmol), PPh3 (0.1 mmol), Et3N (1.2 mmol), and N,N-dimethylacetamide (2 mL) were added to the reactor in a glove box. The autoclave was tightened. CO and H2 were injected into the autoclave to bring the total pressure to 10 bar (1:1). The mixture was transferred to an oil bath preheated at 90°C for 12 hours. The reaction was controlled using a Haake-D3 temperature controller. After the reaction was complete, the reactor was cooled in ice water. The atmosphere was carefully vented. Add 5 mL of CH₂Cl₂ to the reaction mixture. Add 10 mL of deionized water to the mixture and extract five times with the solvent N,N-dimethylacetamide. Dry the organic layer with anhydrous Na₂SO₄. Concentrate the organic layer by rotary evaporation. Purify the product by silica gel column chromatography using n-hexane/ethyl acetate as eluent. | | Chemical Properties | white to light yellow crystal powder | | Uses | 4-Chloro-3-fluorobenzaldehyde is an organic intermediate that can be prepared from 4-chloro-3-fluoroiodobenzene in one step. It has been reported in the literature that it can be used to prepare piperidine derivatives. |
| | 4-Chloro-3-fluorobenzaldehyde Preparation Products And Raw materials |
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