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ChemicalBook >> CAS DataBase List >>4'-Hydroxy-3'-methoxypropiophenone

4'-Hydroxy-3'-methoxypropiophenone

4'-Hydroxy-3'-methoxypropiophenone Structure
4'-Hydroxy-3'-methoxypropiophenone structure
CAS No.
1835-14-9
Chemical Name:
4'-Hydroxy-3'-methoxypropiophenone
Synonyms
PROPIOVANILLONE;4-HYDROXY-3-METHOXYPROPIOPHENONE;1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)-;Propioguaiacone;Eugenol Impurity 21;3-METHOXY-4-HYDROXYPROPIOPHENONE;4'-hydroxy-3'-methoxypropiophenone;Propiophenone, 4'-hydroxy-3'-methoxy;1-(4-hydroxy-3-methoxyphenyl)-1-propanone;1-(4-HYDROXY-3-METHOXY-PHENYL)-PROPAN-1-ONE
CBNumber:
CB3205110
Molecular Formula:
C10H12O3
Molecular Weight:
180.2
MDL Number:
MFCD00482070
MOL File:
1835-14-9.mol
MSDS File:
SDS
Last updated:2026-05-28 01:02:45
Product description Number Pack Size Price
1-(4-Hydroxy-3-methoxyphenyl)-1-propanone TRC-H947600-25MG 25mg $176
1-(4-Hydroxy-3-methoxyphenyl)-1-propanone TRC-H947600-250MG 250mg $354
1-(4-Hydroxy-3-methoxyphenyl)-1-propanone TRC-H947600-10MG 10mg $97
4-Hydroxy-3-methoxypropiophenone FH67519 2g $163.28
4-Hydroxy-3-methoxypropiophenone FH67519 5g $362.8
More product size
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4'-Hydroxy-3'-methoxypropiophenone Properties

Melting point 61-62 °C
Boiling point 180-185 °C(Press: 15 Torr)
Density 1.126±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 8.92±0.31(Predicted)
color White to Dark Beige
LogP 2.020 (est)
CAS DataBase Reference 1835-14-9(CAS DataBase Reference)
FDA UNII B6B3PL2HRF
NIST Chemistry Reference 1-(4-hydroxy-3-methoxyphenyl)propanone(1835-14-9)
EPA Substance Registry System 1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)- (1835-14-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Environment (GHS09)Skull and Crossbones (GHS06)
GHS09,GHS06
Signal word  Danger
Hazard statements  H411-H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501
Hazard Codes  T,N
Risk Statements  25-51/53
Safety Statements  45-61
HS Code  2914500090

4'-Hydroxy-3'-methoxypropiophenone price More Price(44)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-H947600-25MG 1-(4-Hydroxy-3-methoxyphenyl)-1-propanone 1835-14-9 25mg $176 2026-06-03 Buy
TRC TRC-H947600-250MG 1-(4-Hydroxy-3-methoxyphenyl)-1-propanone 1835-14-9 250mg $354 2026-06-03 Buy
TRC TRC-H947600-10MG 1-(4-Hydroxy-3-methoxyphenyl)-1-propanone 1835-14-9 10mg $97 2026-06-03 Buy
Biosynth FH67519 4-Hydroxy-3-methoxypropiophenone 1835-14-9 2g $163.28 2026-06-04 Buy
Biosynth FH67519 4-Hydroxy-3-methoxypropiophenone 1835-14-9 5g $362.8 2026-06-04 Buy
Product number Packaging Price Buy
TRC-H947600-25MG 25mg $176 Buy
TRC-H947600-250MG 250mg $354 Buy
TRC-H947600-10MG 10mg $97 Buy
FH67519 2g $163.28 Buy
FH67519 5g $362.8 Buy

4'-Hydroxy-3'-methoxypropiophenone Chemical Properties,Uses,Production

Uses

1-(4-Hydroxy-3-methoxyphenyl)-1-propanone is a derivative of Guaiacol, a precursor to various flavorants, such as eugenol and vanillin.

Preparation

Preparation by Fries rearrangement of 2-methoxyphenyl propionate, (b.p.20 140–143°)
with aluminium chloride in nitrobenzene, first at 60–80° for 1 h, then at r.t. overnight, at 60° for 1 h or at 50° for 5 h (44%) ;
with aluminium chloride (2 mol) in nitromethane at r.t. for 24 h (65%)
with aluminium chloride in carbon disulfide
with titanium tetrachloride (2 mol) in nitromethane at r.t. for 24 h (62%)
with stannic chloride (2 mol) in nitromethane at r.t. for 24 h (69%)
with antimony pentachloride (2 mol) in nitromethane at r.t. for 24 h (28%) with formation of important tars.

Synthesis Reference(s)

The Journal of Organic Chemistry, 15, p. 227, 1950 DOI: 10.1021/jo01148a001

Synthesis

(2-methoxyphenyl) propanoate

7598-60-9

4'-Hydroxy-3'-methoxypropiophenone

1835-14-9

The general procedure for the synthesis of 3-methoxy-4-hydroxypropiophenone from (2-methoxyphenyl) propionate is as follows: powdered anhydrous aluminum chloride (3.0 g, 22.5 mmol) was dissolved in anhydrous nitrobenzene (10 mL) at 100 °C. After cooling to room temperature, 2-methoxyphenyl propionate (2.0 g, 11.1 mmol) was quickly added. The reaction mixture was heated at 60 °C for 1.5 h and subsequently cooled to room temperature. A 3N NaOH solution was added to the reaction mixture and stirred for 15 minutes. The suspension was filtered and the solid was washed with water. The filtrate was washed twice with dichloromethane (CH2Cl2) and then acidified with 3N HCl. The acidified aqueous phase was extracted with dichloromethane and the organic phases were combined. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: petroleum ether/ethyl acetate = 10/1 to 5/1) to afford the target compound 3-methoxy-4-hydroxypropiophenone (874 mg, 44% yield) as a yellow oil.

References

[1] Patent: WO2013/97773, 2013, A1. Location in patent: Paragraph 0154
[2] Journal of the Chemical Society, 1930, p. 280,291
[3] Journal of the American Chemical Society, 1948, vol. 70, p. 60,62

4'-Hydroxy-3'-methoxypropiophenone Preparation Products And Raw materials

Raw materials

(2-methoxyphenyl) propanoate Nitrobenzene Aluminum chloride

Preparation Products

2-Chloro-1-(4-hydroxy-3-methoxyphenyl)propan-1-one

4'-Hydroxy-3'-methoxypropiophenone Suppliers

Global( 104)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29812 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Wuhan Chemwish Technology Co., Ltd 		027-67849912 sales@chemwish.com CHINA 10821 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 9976 58
SIMAGCHEM CORP 		+86-5922680277 +86-13806087780 sale@simagchem.com China 17346 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14304 58
Changzhou Anxuan Chemical Co., Ltd 		+86-0519-89882563 +86-18961279162 andy@anxuanchem.com China 4327 58
changzhou huayang technology co., ltd 		+8615250961469 2571773637@qq.com China 9653 58
Aromsyn Co., Ltd. 		+86-0571-85585865 +8613336024896 CB@aromsyn.com China 19183 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615531151365 mina@chuanghaibio.com China 18126 58
Supplier Advantage
career henan chemical co 		58
Alchem Pharmtech,Inc. 		58
Wuhan Chemwish Technology Co., Ltd 		58
Fuxin Pharmaceutical 		58
SIMAGCHEM CORP 		58
Win-Win chemical CO., Limited 		58
Changzhou Anxuan Chemical Co., Ltd 		58
changzhou huayang technology co., ltd 		58
Aromsyn Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58

View Lastest Price from 4'-Hydroxy-3'-methoxypropiophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-Hydroxy-3'-methoxypropiophenone pictures 2019-08-30 4'-Hydroxy-3'-methoxypropiophenone
1835-14-9
 $1.00 1KG 98% 200kg Career Henan Chemical Co

4'-Hydroxy-3'-methoxypropiophenone Spectrum

4'-Hydroxy-3'-methoxypropiophenone(1835-14-9)1HNMR

1835-14-9(4'-Hydroxy-3'-methoxypropiophenone)Related Search:

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4',6,7-Trimethoxyisoflavone Glycitein Cryptopine 4-(3,4-DIMETHOXYPHENYL)-4-OXOBUTYRIC ACID Oxolinic acid
Methoxypropiophenone 4'-Hydroxypropiophenone Protopine

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3-METHOXY-4-HYDROXYPROPIOPHENONE 1-(4-Hydroxy-3-methoxyphenyl)-1-propanone (propiovanillone) Propioguaiacone Propiophenone, 4'-hydroxy-3'-methoxy 1-(4-hydroxy-3-methoxyphenyl)-1-propanone 1-(4-HYDROXY-3-METHOXY-PHENYL)-PROPAN-1-ONE Eugenol Impurity 21 4'-hydroxy-3'-methoxypropiophenone 1-Propanone, 1-(4-hydroxy-3-methoxyphenyl)- 4-HYDROXY-3-METHOXYPROPIOPHENONE PROPIOVANILLONE 1835-14-9 Aromatic Propiophenones (substituted)