2-Bromo-3-(bromomethyl)pyridine
- CAS No.
- 94446-97-6
- Chemical Name:
- 2-Bromo-3-(bromomethyl)pyridine
- Synonyms
- 2-BROMO-3-(BROMOMETHYL)PYRIDINE;Pyridine, 2-bromo-3-(bromomethyl)-;2-Bromo-3-(bromomethyl)pyridine,96%;2-Bromo-3-(bromomethyl)pyridine ISO 9001：2015 REACH;2-Bromonicotinyl bromide, alpha,2-Dibromo-3-picoline
- CBNumber:
- CB3234990
- Molecular Formula:
- C6H5Br2N
- Molecular Weight:
- 250.92
- MDL Number:
- MFCD08276299
- MOL File:
- 94446-97-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| HS Code | 2933399990 | |||||||||
| NFPA 704 |
|
2-Bromo-3-(bromomethyl)pyridine price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR60069 | 2-Bromo-3-(bromomethyl)pyridine ≥95% | 94446-97-6 | 250mg | $86 | 2026-06-04 | Buy |
| Apolloscientific | OR60069 | 2-Bromo-3-(bromomethyl)pyridine ≥95% | 94446-97-6 | 1g | $252 | 2026-06-04 | Buy |
| Activate Scientific | AS143288 | 2-Bromo-3-(bromomethyl)pyridine 95% | 94446-97-6 | 250mg | $109 | 2026-06-04 | Buy |
| Activate Scientific | AS143288 | 2-Bromo-3-(bromomethyl)pyridine 95% | 94446-97-6 | 1g | $398 | 2026-06-04 | Buy |
| Activate Scientific | AS143288 | 2-Bromo-3-(bromomethyl)pyridine 95% | 94446-97-6 | 5g | $948 | 2026-06-04 | Buy |
2-Bromo-3-(bromomethyl)pyridine Chemical Properties, Uses, Production
Synthesis
3430-17-9
94446-97-6
General procedure for the synthesis of 2-bromo-3-(bromomethyl)pyridine from 2-bromo-3-methylpyridine: The intermediate was prepared by a modification of the method based on that disclosed by Rebek, J., et al. in J. Am. Chem. Soc., 107, 7487 (1985). A three-necked round-bottomed flask equipped with a stirring bar was flame dried, vacuum cooled and purged with nitrogen. To the flask were added 2-bromo-3-methylpyridine (5.2 mL, 29.1 mmol), N-bromosuccinimide (5.5 g, 32.0 mmol) and degassed benzene (126 mL). The flask was equipped with a condenser, heated to 40 °C and AIBN (0.24 g, 1.5 mmol) was added in batches. The reaction mixture was stirred at 40 °C and irradiated using a sun lamp. The reaction progress was monitored by TLC and HPLC and stopped when the conversion of pyridine reagent reached 80% (about 8 h). The reaction mixture was concentrated under reduced pressure and then redissolved in a 4:1 solvent mixture of dichloromethane/ethyl acetate (120 mL) and extracted sequentially with 50 mL each of saturated aqueous sodium bicarbonate, water and saturated aqueous sodium chloride. The organic phase was dried with anhydrous sodium sulfate, filtered and concentrated. After standing, the residue was not completely soluble in dichloromethane and the resulting suspension was filtered to remove insoluble solids. The filtrate was concentrated to near dryness and the residue was purified by normal phase fast chromatography (ethyl acetate/hexane) to afford 2-bromo-3-(bromomethyl)pyridine (3.0 g, 11.9 mmol, 41%) as a yellow solid.1H NMR (400 MHz, CDCl3) δ 8.33 (1H, dd, J=5, 2 Hz), 7.78 (1H, dd, J=7 , 2 Hz), 7.28 (1H, dd, J=5, 4 Hz), 4.57 (2H, s).MS (LC/MS) m/z Observed 249.97, Expected 249.89 [M+H]+.
References
[1] Journal of the American Chemical Society, 1985, vol. 107, # 25, p. 7487 - 7493
[2] Heterocycles, 1984, vol. 22, # 10, p. 2191 - 2194
[3] Patent: WO2016/15159, 2016, A1. Location in patent: Page/Page column 55
[4] Patent: US9458192, 2016, B1. Location in patent: Page/Page column 44
[5] ACS Medicinal Chemistry Letters, 2011, vol. 2, # 8, p. 559 - 564
2-Bromo-3-(bromomethyl)pyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| ITIC MEDCHEM(SUZHOU) CO.,LTD. | 0512-68323967 18015559028 | sales@iticmedchem.com | China | 528 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Atop-Pharma (Shanghai) Technology Co., Ltd. | +86 (21) 5196-9732 | China | 996 | 57 | |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Suzhou Sibian Chemical Technology Co.,Ltd. | 0512-65617459 18915409046 | sales@sibian-chem.com | China | 1917 | 55 |
View Latest Price from 2-Bromo-3-(bromomethyl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Bromo-3-(bromomethyl)pyridine
94446-97-6
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-01-13 | 2-Bromo-3-(bromomethyl)pyridine
94446-97-6
|
$5.50 | 1KG | 98%min | 1kg-100kg | Career Henan Chemical Co |
-
- 2-Bromo-3-(bromomethyl)pyridine
94446-97-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Bromo-3-(bromomethyl)pyridine
94446-97-6
- $5.50
- 98%min
- Career Henan Chemical Co
