3,3-DIETHOXY-1-PROPANOL
- CAS No.
- 16777-87-0
- Chemical Name:
- 3,3-DIETHOXY-1-PROPANOL
- Synonyms
- 3,3-diethoxypropanol;3,3-DIETHOXY-1-PROPANOL;3,3-Diethoxy-propan-1-ol;1-Propanol, 3,3-diethoxy-;3,3-Diethoxy-1-propanol 98%;3-hydroxypropionaldehyde diethyl acetal
- CBNumber:
- CB3243815
- Molecular Formula:
- C7H16O3
- Molecular Weight:
- 148.2
- MDL Number:
- MFCD00074850
- MOL File:
- 16777-87-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 3,3-Diethoxy-1-propanol 98% | 273252 | 1g | $62.9 |
| 3,3-Diethoxy-1-propanol 98% | 273252 | 5g | $194 |
| 3,3-Diethoxy-1-propanol | TRC-D442995-250MG | 250mg | $65 |
| 3,3-Diethoxy-1-propanol | TRC-D442995-2.5G | 2.5g | $334 |
| 3,3-Diethoxy-1-propanol | TRC-D442995-1G | 1g | $179 |
| More product size | |||
| Boiling point | 90-93 °C/14 mmHg (lit.) |
|---|---|
| Density | 0.941 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 196 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| pka | 15.05±0.10(Predicted) |
| color | Clear colorless |
| InChI | InChI=1S/C7H16O3/c1-3-9-7(5-6-8)10-4-2/h7-8H,3-6H2,1-2H3 |
| InChIKey | ASERXEZXVIJBRO-UHFFFAOYSA-N |
| SMILES | C(O)CC(OCC)OCC |
| LogP | 0.789 (est) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H335-H319 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| PPE | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
| WGK Germany | 3 |
| HS Code | 29094980 |
| Storage Class | 10 - Combustible liquids |
3,3-DIETHOXY-1-PROPANOL price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 273252 | 3,3-Diethoxy-1-propanol 98% | 16777-87-0 | 1g | $62.9 | 2026-04-30 | Buy |
| Sigma-Aldrich | 273252 | 3,3-Diethoxy-1-propanol 98% | 16777-87-0 | 5g | $194 | 2026-04-30 | Buy |
| TRC | TRC-D442995-250MG | 3,3-Diethoxy-1-propanol | 16777-87-0 | 250mg | $65 | 2026-06-03 | Buy |
| TRC | TRC-D442995-2.5G | 3,3-Diethoxy-1-propanol | 16777-87-0 | 2.5g | $334 | 2026-06-03 | Buy |
| TRC | TRC-D442995-1G | 3,3-Diethoxy-1-propanol | 16777-87-0 | 1g | $179 | 2026-06-03 | Buy |
3,3-DIETHOXY-1-PROPANOL Chemical Properties,Uses,Production
Uses
3,3-Diethoxy-1-propanol was used in the synthesis of α-acetal-poly(ethylene glycol) via reaction with potassium napthalide and ethylene oxide inside an UniLab Glovebox.
Synthesis
10601-80-6
16777-87-0
Tetrahydrofuran (THF) was dehydrated through 4Å molecular sieves overnight and set aside. Under nitrogen protection, 2.2 kg of dehydrated THF was added to a 5 L four-necked flask and cooled to below 10 °C. 50 g of lithium aluminum hydride was slowly added, followed by dropwise addition of 250 g of ethyl 3,3-diethoxypropionate, controlling the internal temperature not to exceed 10 °C. After the dropwise addition was completed, the temperature was raised to 20°C and the reaction was carried out for 1 hour. After completion of the reaction, 420 g of distilled water was added and stirred for 2 h. The filtrate was filtered through No. 2 filter paper and the cake was washed with 1.1 kg of THF. The filtrate was concentrated at 40 °C to give 213 g of crude 3,3-diethoxy-1-propanol (abbreviated as 33DEP). 200g of crude 33DEP was taken in a 5L four-necked flask, 1kg of hexane was added and stirred for 1 hour (Step A). Add 1kg of 0.1M phosphate buffer (pH 7.5), stir for 20 minutes and transfer to a 5L separatory funnel and leave to stratify. After separating the aqueous layer, the hexane layer was returned to the flask and the aqueous layer was recovered by repeating the addition of 1 kg of 0.1 M phosphate buffer (pH 7.5), stirring for 20 minutes, and again transferring to a partitioning funnel for stationary partitioning (Step B). The combined aqueous layer was transferred back to a 5L four-necked flask, 2kg of chloroform was added, stirred for 30 minutes, transferred to a 5L partition funnel and left to stratify for 15 minutes. The chloroform layer was recovered and the aqueous layer was repeated once with 2 kg chloroform extraction and the chloroform layers were combined (Step C). The chloroform layer was concentrated at 40°C and residual solvent was removed by nitrogen bubbling. 20g of 4Å molecular sieve was added and filtered after stirring for 5 h to give 188 g of 33DEP. 150 g of 33DEP was taken in a 300 mL four neck flask and subjected to reduced pressure distillation. The first fraction was collected at 0.4 kPa, bath temperature of 38°C, internal temperature of 36°C, and temperature at the top of the tower of 33°C. Subsequently, the bath temperature was gradually increased, and the main fraction was collected at 0.2 kPa, bath temperature of 58 °C, internal temperature of 55 °C, and temperature of the top of the tower of 54 °C, and the temperature of the top of the tower was controlled not to exceed 60 °C, and finally 138 g of the main fraction was obtained (Step D). The main fraction was analyzed by GC and the results are shown in Table 1.
References
[1] Patent: US2012/277477, 2012, A1. Location in patent: Page/Page column 5
[2] Acta Chemica Scandinavica (1947-1973), 1973, vol. 27, p. 239 - 250
[3] Patent: US4634773, 1987, A
3,3-DIETHOXY-1-PROPANOL Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10399 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Fuxin Pharmaceutical | +86-021-021-50872116 | contact@fuxinpharm.com | China | 9976 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| changzhou huayang technology co., ltd | +8615250961469 | 2571773637@qq.com | China | 9628 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 +8619957148339 | market18@leapchem.com | China | 24569 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20111 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 |
View Lastest Price from 3,3-DIETHOXY-1-PROPANOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 3,3-DIETHOXY-1-PROPANOL
16777-87-0
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | 3,3-DIETHOXY-1-PROPANOL
16777-87-0
|
$1.00 | 1KG | 98% | 1 | Career Henan Chemical Co |
-
- 3,3-DIETHOXY-1-PROPANOL
16777-87-0
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3,3-DIETHOXY-1-PROPANOL
16777-87-0
- $1.00
- 98%
- Career Henan Chemical Co
