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2-Chloro-5-fluorobenzothiazole

2-Chloro-5-fluorobenzothiazole Structure
2-Chloro-5-fluorobenzothiazole structure
CAS No.
154327-27-2
Chemical Name:
2-Chloro-5-fluorobenzothiazole
Synonyms
2-Chloro-5-fluorobenzo[d]thiazole;2-Chloro-5-fluorobenzothiazole;Benzothiazole, 2-chloro-5-fluoro-
CBNumber:
CB32450103
Molecular Formula:
C7H3ClFNS
Molecular Weight:
187.62
MDL Number:
MFCD09749234
MOL File:
154327-27-2.mol
MSDS File:
SDS
Last updated:2026-09-12 18:51:52
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2-Chloro-5-fluorobenzothiazole Properties

Boiling point 253.0±13.0 °C(Predicted)
Density 1.532±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka -0.36±0.10(Predicted)
Appearance Off-white to light yellow Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P330-P332+P313-P362-P403+P233-P405-P501
HS Code  29342000

2-Chloro-5-fluorobenzothiazole price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 126387 2-Chloro-5-fluorobenzothiazole 154327-27-2 1.00g $1044 2026-05-18 Buy
Synthonix C44127 2-Chloro-5-fluorobenzo[d]thiazole 97% 154327-27-2 250mg $45 2026-05-06 Buy
Synthonix C44127 2-Chloro-5-fluorobenzo[d]thiazole 97% 154327-27-2 1g $51 2026-05-06 Buy
Synthonix C44127 2-Chloro-5-fluorobenzo[d]thiazole 97% 154327-27-2 5g $200 2026-05-06 Buy
Synthonix C44127 2-Chloro-5-fluorobenzo[d]thiazole 97% 154327-27-2 10g $400 2026-05-06 Buy
Product number Packaging Price Buy
126387 1.00g $1044 Buy
C44127 250mg $45 Buy
C44127 1g $51 Buy
C44127 5g $200 Buy
C44127 10g $400 Buy

2-Chloro-5-fluorobenzothiazole Chemical Properties, Uses, Production

Chemical Properties

Yellow solid

Synthesis

5-FLUORO-2-MERCAPTOBENZOTHIAZOLE

155559-81-2

2-CHLORO-5-FLUOROBENZOTHIAZOLE

154327-27-2

General procedure for the synthesis of 2-chloro-5-fluorobenzothiazole from 5-fluoro-2-mercaptobenzothiazole: Thionyl chloride (0.3 mL, 4.41 mmol) was slowly added dropwise to 5-fluoro-2-mercaptobenzothiazole (680 mg, 3.67 mmol). The reaction mixture was stirred at room temperature for 1 h. The reaction was then warmed up to 60 °C and continued for 40 min. Upon completion of the reaction, the reaction solution was cooled to room temperature, slowly poured into ice water and extracted with ethyl acetate (3 x 50 mL). The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The dried organic phases were concentrated under reduced pressure to afford the target product 2-chloro-5-fluorobenzothiazole (520 mg, 2.75 mmol, 75% yield).ESI-MS (M + 1): 187 (calculated value: C7H3ClFNS, 186).

References

[1] Patent: WO2011/143366, 2011, A1. Location in patent: Page/Page column 57
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7661 - 7670
[3] Patent: US2004/224997, 2004, A1. Location in patent: Page 32; 33
[4] Patent: WO2017/88759, 2017, A1. Location in patent: Paragraph 00233

2-Chloro-5-fluorobenzothiazole synthesis

155559-81-2
154327-27-2
Synthesis of 2-Chloro-5-fluorobenzothiazole from 5-Fluoro-2-mercaptobenzothiazole

2-Chloro-5-fluorobenzothiazole Preparation Products And Raw materials

Raw materials

5-Fluoro-2-mercaptobenzothiazole

Preparation Products

2-Chloro-5-fluorobenzothiazole Suppliers

Global Suppliers ( 82)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
chenyue Chemicals Co., Ltd. +86-0519-85500896 benzoxazolone@163.com China 178 58
Beijing Taiya Jie Technology Development Co., Ltd. 021-33690831-8001 13552411790;18616022633 postmaster@tyjchem.cn China 1541 55
Wuhan Fortuna Chemical Co., Ltd 027-59207852 13308628970 buy@fortunachem.com China 2689 58
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
SynAsst Chemical. 021-60343070 China 12731 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
PharmaBlock Sciences (Nanjing),Inc. 55
Shanghai Longsheng chemical Co.,Ltd. 59
China DongFan Chemical Co.,LTD 66
Jinan Trio PharmaTech Co., Ltd. 62
chenyue Chemicals Co., Ltd. 58
Beijing Taiya Jie Technology Development Co., Ltd. 55
Wuhan Fortuna Chemical Co., Ltd 58
Chiba Pharmaceutical Science and technology Co, Ltd. 55
SynAsst Chemical. 55

View Latest Price from 2-Chloro-5-fluorobenzothiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-fluorobenzothiazole pictures 2022-01-15 2-Chloro-5-fluorobenzothiazole
154327-27-2
 1KG 97.0% 100 tons Honest Joy Holdings Limited
2-CHLORO-5-FLUOROBENZOTHIAZOLE pictures 2019-08-29 2-CHLORO-5-FLUOROBENZOTHIAZOLE
154327-27-2
 $1.00-2.00 1KG 95%-99% 100kg Career Henan Chemical Co

2-Chloro-5-fluorobenzothiazole Spectrum

2-CHLORO-5-FLUOROBENZOTHIAZOLE(154327-27-2)1HNMR2-CHLORO-5-FLUOROBENZOTHIAZOLE(154327-27-2)19FNMR

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Benzothiazole, 2-chloro-5-fluoro- 2-Chloro-5-fluorobenzo[d]thiazole 2-Chloro-5-fluorobenzothiazole 154327-27-2