1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene
- CAS No.
- 1089280-66-9
- Chemical Name:
- 1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene
- Synonyms
- 1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene;1-chlorine-4-fluorine-5-methoxynitrobenzene;Benzene, 1-chloro-2-fluoro-4-methoxy-5-nitro-
- CBNumber:
- CB32550359
- Molecular Formula:
- C7H5ClFNO3
- Molecular Weight:
- 205.57
- MDL Number:
- MOL File:
- 1089280-66-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H335-H302+H312+H332-H315 |
| Precautionary statements | P280-P301+P312-P304+P340 |
| HS Code | 2933399990 |
1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | PTB28066 | 1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene | 1089280-66-9 | 10g | $472 | 2026-06-04 | Buy |
| Apolloscientific | PC50377 | 1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene 97% | 1089280-66-9 | 250mg | $44 | 2026-06-04 | Buy |
| Apolloscientific | PC50377 | 1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene 97% | 1089280-66-9 | 1g | $52 | 2026-06-04 | Buy |
| Apolloscientific | PC50377 | 1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene 97% | 1089280-66-9 | 5g | $105 | 2026-06-04 | Buy |
| Apolloscientific | PC50377 | 1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene 97% | 1089280-66-9 | 10g | $207 | 2026-06-04 | Buy |
1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene Chemical Properties,Uses,Production
Uses
1-Chloro-2-fluoro-4-methoxy-5-nitrobenzene is a hydrocarbon derivative, mainly used as a pharmaceutical intermediate.
Synthesis
501-29-1
1089280-66-9
General procedure for the synthesis of 1-chloro-2-fluoro-4-methoxy-5-nitrobenzene from 4-chloro-3-fluoroanisole: To a concentrated mixture of 1-chloro-2-fluoro-4-methoxybenzene (5.00 g, 31.1 mmol), concentrated H2SO4 (30 mL) was slowly added at 0-10 °C. Potassium nitrate (3.78 g, 37.4 mmol) was then added in batches and the reaction mixture was kept stirred at 0 °C for 2 hours. Upon completion of the reaction, the reaction was quenched with ice water and the solid product was collected by filtration. The resulting solid was purified by recrystallization from hexane to afford 4.50 g (70% yield) of the target compound 1-chloro-2-fluoro-4-methoxy-5-nitrobenzene. The structure of the product was confirmed by 1HNMR (400 MHz, DMSO-d6): δ 8.30 (d, J=2.0 Hz, 1H), 7.61 (d, J=2.3 Hz, 1H), 3.96 (s, 3H); ESI-MS (m/z) 205.76 (MH)+.
References
[1] Patent: WO2014/22349, 2014, A1. Location in patent: Paragraph 00194
[2] Patent: WO2018/20474, 2018, A1. Location in patent: Page/Page column 155
1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene Preparation Products And Raw materials
Raw materials
Preparation Products
1-Chloro-2-fluoro-4-Methoxy-5-nitrobenzene Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3836 | 58 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Jalor-Chem co.,LTD | 0510-0510-86396359 13382276200 | sales@jalor-chem.com | China | 1000 | 56 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Xinyanhe Pharmatech Co.,Ltd | 0519-85252752 15366845260 | taihuaren@vip.163.com | China | 1033 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| ShangHai Yuchuan Pharmaceutical Technology Co., Ltd. | 02161555100 | China | 820 | 58 | |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
