4-Chloro-5-fluoro-2-nitrophenol
- CAS No.
- 345-25-5
- Chemical Name:
- 4-Chloro-5-fluoro-2-nitrophenol
- Synonyms
- 4-chloro-5-fluoro-2-nirophenol;4-Chloro-5-fluoro-2-nitrophenol;2-Nitro-4-chloro-5-fluorophenol;2-amino-4-chloro-5-fluorophenol;Phenol, 4-chloro-5-fluoro-2-nitro-;5-Chloro-4-fluoro-2-hydroxyaniline;5-Chloro-4-fluoro-2-hydroxynitrobenzene;4-CHLORO-5-FLUORO-2-NITROPHENOL ISO 9001：2015 REACH
- CBNumber:
- CB52465589
- Molecular Formula:
- C6H3ClFNO3
- Molecular Weight:
- 191.54
- MDL Number:
- MFCD11840294
- MOL File:
- 345-25-5.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P280-P271 |
| HS Code | 2908990000 |
4-Chloro-5-fluoro-2-nitrophenol price More Price(40)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC10643 | 4-Chloro-5-fluoro-2-nitrophenol 98% | 345-25-5 | 1g | $49 | 2026-06-04 | Buy |
| Apolloscientific | PC10643 | 4-Chloro-5-fluoro-2-nitrophenol 98% | 345-25-5 | 5g | $187 | 2026-06-04 | Buy |
| Matrix Scientific | 084616 | 4-Chloro-5-fluoro-2-nitrophenol | 345-25-5 | 1.00g | $561 | 2026-05-18 | Buy |
| Synthonix | C41975 | 4-Chloro-5-fluoro-2-nitrophenol 95% | 345-25-5 | 100mg | $21 | 2026-05-06 | Buy |
| Synthonix | C41975 | 4-Chloro-5-fluoro-2-nitrophenol 95% | 345-25-5 | 250mg | $27 | 2026-05-06 | Buy |
4-Chloro-5-fluoro-2-nitrophenol Chemical Properties, Uses, Production
Synthesis
348-60-7
345-25-5
General procedure for the synthesis of 4-chloro-5-fluoro-2-nitrophenol from 4-chloro-3-fluorophenol: 4-chloro-3-fluorophenol (2.38 g, 16.2 mmol) was dissolved in dichloroethane (DCE, 32 mL), followed by addition of tetrabutylammonium bromide (0.524 g, 1.62 mmol). A 7% nitric acid solution was prepared by diluting 70% nitric acid (HNO3, 2.1 mL, 32 mmol) with water (18.9 mL). This nitric acid solution was slowly added to the reaction mixture and the reaction was stirred at room temperature for 4 h. The progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was completed. After completion of the reaction, the reaction mixture was poured into water and extracted with dichloromethane (DCM, 3 × 30 mL). The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The obtained residue was adsorbed on silica gel and purified by fast column chromatography to afford the target product 4-chloro-5-fluoro-2-nitrophenol (2.29 g, 74% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 11.76 (br.s, 1H), 8.18 (d, J = 8.1 Hz, 1H), 7.10 (d, J = 10.6 Hz, 1H).
References
[1] Patent: US2008/300242, 2008, A1. Location in patent: Page/Page column 114
[2] Journal of the Chemical Society, 1949, p. 3437
[3] Patent: WO2011/151361, 2011, A1. Location in patent: Page/Page column 27
4-Chloro-5-fluoro-2-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Eternalchem Co,. Ltd. | 010-59484199 18611897322;18611897322; | sales@eternalchem.com | China | 1993 | 60 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3828 | 58 |
| Shanghai Na Qian Chemical Technology Co. Ltd. | 13598610367 13598610367 | 2841375912@qq.com | China | 3760 | 52 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
| Shanghai CR Corporation Limited | 13917420128 13062833949 | fred.wen@crcorporation.cn | China | 9776 | 58 |
| Hangzhou Molcore Biopharmatech Co.,Ltd | 400-711-5280 86-571-81025280 | sales@molcore.com | China | 9957 | 58 |
View Latest Price from 4-Chloro-5-fluoro-2-nitrophenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-13 | 4-CHLORO-5-FLUORO-2-NITROPHENOL
345-25-5
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- 4-CHLORO-5-FLUORO-2-NITROPHENOL
345-25-5
- $1.00
- 99.0%
- Career Henan Chemical Co
