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2-Bromo-5-fluoro-4-nitroaniline

2-Bromo-5-fluoro-4-nitroaniline Structure
2-Bromo-5-fluoro-4-nitroaniline structure
CAS No.
952664-69-6
Chemical Name:
2-Bromo-5-fluoro-4-nitroaniline
Synonyms
2-Bromo-5-fluoro-4-nitro-phenylamine;2-BroMo-5-fluoro-4-nitroaniline;2-broMo-5-fluoro-4-nitrobenzenaMine;BenzenaMine, 2-broMo-5-fluoro-4-nitro-;BenzenaMine, 2-broMo-5-fluoro-4-nitro-2
CBNumber:
CB32624670
Molecular Formula:
C6H4BrFN2O2
Molecular Weight:
235.01
MDL Number:
MFCD22381005
MOL File:
952664-69-6.mol
Last updated:2026-05-28 01:08:21
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2-Bromo-5-fluoro-4-nitroaniline Properties

Boiling point 364.5±37.0 °C(Predicted)
Density 1.896±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka -2.19±0.14(Predicted)
Appearance Light yellow to yellow Solid
InChI InChI=1S/C6H4BrFN2O2/c7-3-1-6(10(11)12)4(8)2-5(3)9/h1-2H,9H2
InChIKey PKDUOURYTVRBLI-UHFFFAOYSA-N
SMILES C1(N)=CC(F)=C([N+]([O-])=O)C=C1Br

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2921410090

2-Bromo-5-fluoro-4-nitroaniline price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth CNB66469 2-Bromo-5-fluoro-4-nitroaniline 952664-69-6 100g $649 2026-06-04 Buy
Biosynth CNB66469 2-Bromo-5-fluoro-4-nitroaniline 952664-69-6 250g $972.5 2026-06-04 Buy
Apolloscientific PC500296 2-Bromo-5-fluoro-4-nitroaniline >98% 952664-69-6 5g $21 2026-06-04 Buy
Apolloscientific PC500296 2-Bromo-5-fluoro-4-nitroaniline >98% 952664-69-6 25g $85 2026-06-04 Buy
Apolloscientific PC500296 2-Bromo-5-fluoro-4-nitroaniline >98% 952664-69-6 100g $286 2026-06-04 Buy
Product number Packaging Price Buy
CNB66469 100g $649 Buy
CNB66469 250g $972.5 Buy
PC500296 5g $21 Buy
PC500296 25g $85 Buy
PC500296 100g $286 Buy

2-Bromo-5-fluoro-4-nitroaniline Chemical Properties, Uses, Production

Uses

2-Bromo-5-fluoro-4-nitroaniline is a polysubstituted aniline compound containing substituents such as bromine, nitro and fluorine atoms in the 2, 4 and 5 positions of the benzene ring, respectively. This product can be used as an intermediate for Tezacaftor, a cystic fibrosis (CF) combination used to treat patients 6 years of age and older.

Synthesis

3-Fluoro-4-nitroaniline

2369-13-3

2-Bromo-5-fluoro-4-nitroaniline

952664-69-6

Bromine (2.15 mL, 42.2 mmol) was added slowly and dropwise to a mixed solution of 3-fluoro-4-nitroaniline (6.5 g, 42.2 mmol) in acetic acid (80 mL) and chloroform (25 mL) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours and then poured into ice water. The pH of the mixture was adjusted to 8.0-9.0 with 10% aqueous sodium hydroxide solution under cooling in an ice bath, followed by extraction with ethyl acetate (50 mL × 3). The organic phases were combined, washed sequentially with water (80 mL × 2) and saturated saline (100 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 2-bromo-5-fluoro-4-nitroaniline (9 g, 90% yield). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 8.26 (d, J=8.0 Hz, 1H), 7.07 (brs, 2H), 6.62 (d, J=9.6 Hz, 1H).

References

[1] Patent: US2007/244159, 2007, A1. Location in patent: Page/Page column 112-113
[2] Patent: US2011/98311, 2011, A1
[3] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 1640; 1979
[4] Patent: WO2010/53471, 2010, A1. Location in patent: Page/Page column 56-57
[5] Patent: WO2016/109362, 2016, A1. Location in patent: Paragraph 00168

2-Bromo-5-fluoro-4-nitroaniline Preparation Products And Raw materials

Raw materials

3-Fluoro-4-nitroaniline Water Acetic acid Sodium hydroxide Chloroform

Preparation Products

2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)- 3-Butynoic acid, 4-(2-aMino-4-fluoro-5-nitrophenyl)-2,2-diMethyl-, phenylMethyl ester

2-Bromo-5-fluoro-4-nitroaniline Suppliers

Global Suppliers ( 164)
Supplier Tel Email Country ProdList Advantage
FUXIN QINGJISHENG SCIENCE AND TECHNOLOGY CO.,LID 15940530539 15396717197 361811402@qq.com China 650 58
JiangYin Ruisheng Chemical Co., Ltd. 13003356808 1485751188@qq.com China 403 55
LinkChem Technology Co., Ltd. 021-58950110 13124863828 sales@linkchem.cn China 2994 58
Changzhou Huanling Chemical Co., Ltd. 89803005 18206112582 info@huanlingchem.com China 983 68
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16306 64
Tianjin Jinyuda Chemical Co., Ltd. 022-58013646 13011382049 sales@jinyudachem.com China 1976 55
Nanjing JinruiJiuAn Biotechnology Co., Ltd. 025-58196018 800028039 sales@fartop.net China 2227 55
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 21-33585366 13311639313 sales@shyrchem.com China 807 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
shanghai aokchem co., ltd 021-68712331 39130253 aokchem@gmail.com China 332 58
Supplier Advantage
FUXIN QINGJISHENG SCIENCE AND TECHNOLOGY CO.,LID 58
JiangYin Ruisheng Chemical Co., Ltd. 55
LinkChem Technology Co., Ltd. 58
Changzhou Huanling Chemical Co., Ltd. 68
Nanjing Chemlin Chemical Co., Ltd 64
Tianjin Jinyuda Chemical Co., Ltd. 55
Nanjing JinruiJiuAn Biotechnology Co., Ltd. 55
SHANGHAI YINGRUI CHEMICAL TECHNOLOGY CO.,LTD. 55
Haoyuan Chemexpress Co., Ltd. 61
shanghai aokchem co., ltd 58

View Latest Price from 2-Bromo-5-fluoro-4-nitroaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BenzenaMine, 2-broMo-5-fluoro-4-nitro- pictures 2020-01-10 BenzenaMine, 2-broMo-5-fluoro-4-nitro-
952664-69-6
 $1.00 1g 99% 10000KGS Career Henan Chemical Co

2-Bromo-5-fluoro-4-nitroaniline Spectrum

2-Bromo-5-fluoro-4-nitroaniline(952664-69-6)1HNMR

952664-69-6 (2-Bromo-5-fluoro-4-nitroaniline) Related Search:

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BenzenaMine, 2-broMo-5-fluoro-4-nitro- 2-broMo-5-fluoro-4-nitrobenzenaMine BenzenaMine, 2-broMo-5-fluoro-4-nitro-2 2-Bromo-5-fluoro-4-nitro-phenylamine 2-BroMo-5-fluoro-4-nitroaniline 952664-69-6