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2-Bromo-5-fluoro-4-nitroaniline

2-Bromo-5-fluoro-4-nitroaniline Structure
2-Bromo-5-fluoro-4-nitroaniline structure
CAS No.
952664-69-6
Chemical Name:
2-Bromo-5-fluoro-4-nitroaniline
Synonyms
2-Bromo-5-fluoro-4-nitro-phenylamine;2-BroMo-5-fluoro-4-nitroaniline;2-broMo-5-fluoro-4-nitrobenzenaMine;BenzenaMine, 2-broMo-5-fluoro-4-nitro-;BenzenaMine, 2-broMo-5-fluoro-4-nitro-2
CBNumber:
CB32624670
Molecular Formula:
C6H4BrFN2O2
Molecular Weight:
235.01
MDL Number:
MFCD22381005
MOL File:
952664-69-6.mol
Last updated:2026-05-28 01:08:21
Product description Number Pack Size Price
2-Bromo-5-fluoro-4-nitroaniline 102622 1.00g $152
2-Bromo-5-fluoro-4-nitroaniline 102622 5.00g $388
2-Bromo-5-fluoro-4-nitroaniline 97% B26858 250mg $25
2-Bromo-5-fluoro-4-nitroaniline 97% B26858 1g $29
2-Bromo-5-fluoro-4-nitroaniline 97% B26858 5g $31
More product size
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2-Bromo-5-fluoro-4-nitroaniline Properties

Boiling point 364.5±37.0 °C(Predicted)
Density 1.896±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka -2.19±0.14(Predicted)
Appearance Light yellow to yellow Solid
InChI InChI=1S/C6H4BrFN2O2/c7-3-1-6(10(11)12)4(8)2-5(3)9/h1-2H,9H2
InChIKey PKDUOURYTVRBLI-UHFFFAOYSA-N
SMILES C1(N)=CC(F)=C([N+]([O-])=O)C=C1Br

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
HS Code  2921410090

2-Bromo-5-fluoro-4-nitroaniline price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 102622 2-Bromo-5-fluoro-4-nitroaniline 952664-69-6 1.00g $152 2026-05-18 Buy
Matrix Scientific 102622 2-Bromo-5-fluoro-4-nitroaniline 952664-69-6 5.00g $388 2026-05-18 Buy
Synthonix B26858 2-Bromo-5-fluoro-4-nitroaniline 97% 952664-69-6 250mg $25 2026-05-06 Buy
Synthonix B26858 2-Bromo-5-fluoro-4-nitroaniline 97% 952664-69-6 1g $29 2026-05-06 Buy
Synthonix B26858 2-Bromo-5-fluoro-4-nitroaniline 97% 952664-69-6 5g $31 2026-05-06 Buy
Product number Packaging Price Buy
102622 1.00g $152 Buy
102622 5.00g $388 Buy
B26858 250mg $25 Buy
B26858 1g $29 Buy
B26858 5g $31 Buy

2-Bromo-5-fluoro-4-nitroaniline Chemical Properties,Uses,Production

Uses

2-Bromo-5-fluoro-4-nitroaniline is a polysubstituted aniline compound containing substituents such as bromine, nitro and fluorine atoms in the 2, 4 and 5 positions of the benzene ring, respectively. This product can be used as an intermediate for Tezacaftor, a cystic fibrosis (CF) combination used to treat patients 6 years of age and older.

Synthesis

3-Fluoro-4-nitroaniline

2369-13-3

2-Bromo-5-fluoro-4-nitroaniline

952664-69-6

Bromine (2.15 mL, 42.2 mmol) was added slowly and dropwise to a mixed solution of 3-fluoro-4-nitroaniline (6.5 g, 42.2 mmol) in acetic acid (80 mL) and chloroform (25 mL) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours and then poured into ice water. The pH of the mixture was adjusted to 8.0-9.0 with 10% aqueous sodium hydroxide solution under cooling in an ice bath, followed by extraction with ethyl acetate (50 mL × 3). The organic phases were combined, washed sequentially with water (80 mL × 2) and saturated saline (100 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 2-bromo-5-fluoro-4-nitroaniline (9 g, 90% yield). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ 8.26 (d, J=8.0 Hz, 1H), 7.07 (brs, 2H), 6.62 (d, J=9.6 Hz, 1H).

References

[1] Patent: US2007/244159, 2007, A1. Location in patent: Page/Page column 112-113
[2] Patent: US2011/98311, 2011, A1
[3] Patent: US2015/231142, 2015, A1. Location in patent: Paragraph 1640; 1979
[4] Patent: WO2010/53471, 2010, A1. Location in patent: Page/Page column 56-57
[5] Patent: WO2016/109362, 2016, A1. Location in patent: Paragraph 00168

2-Bromo-5-fluoro-4-nitroaniline Preparation Products And Raw materials

Raw materials

3-Fluoro-4-nitroaniline Water Acetic acid Sodium hydroxide Chloroform

Preparation Products

2-Propanol, 1-[(2-broMo-5-fluoro-4-nitrophenyl)aMino]-3-(phenylMethoxy)-, (2R)- 3-Butynoic acid, 4-(2-aMino-4-fluoro-5-nitrophenyl)-2,2-diMethyl-, phenylMethyl ester

2-Bromo-5-fluoro-4-nitroaniline Suppliers

Global( 159)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		+8613336195806 sales@capot.com China 29640 60
Fluoropharm Co., Ltd. 		+86-0571-85586753 +86-13336034509 sales@fluoropharm.com China 1445 60
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4241 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10403 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Fuxin Pharmaceutical 		+86-021-021-50872116 +8613122107989 contact@fuxinpharm.com China 10000 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Win-Win chemical CO., Limited 		+86-0086-577-64498589 +86-15355981851 sales@win-winchemical.com China 14304 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894 shawn@hirisunpharm.com CHINA 9911 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Fluoropharm Co., Ltd. 		60
Changzhou Ansciep Chemical Co., Ltd. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
career henan chemical co 		58
Fuxin Pharmaceutical 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58
Win-Win chemical CO., Limited 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
Hefei Hirisun Pharmatech Co., Ltd 		58

View Lastest Price from 2-Bromo-5-fluoro-4-nitroaniline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BenzenaMine, 2-broMo-5-fluoro-4-nitro- pictures 2020-01-10 BenzenaMine, 2-broMo-5-fluoro-4-nitro-
952664-69-6
 $1.00 1g 99% 10000KGS Career Henan Chemical Co

2-Bromo-5-fluoro-4-nitroaniline Spectrum

2-Bromo-5-fluoro-4-nitroaniline(952664-69-6)1HNMR

952664-69-6(2-Bromo-5-fluoro-4-nitroaniline)Related Search:

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BenzenaMine, 2-broMo-5-fluoro-4-nitro- 2-broMo-5-fluoro-4-nitrobenzenaMine BenzenaMine, 2-broMo-5-fluoro-4-nitro-2 2-Bromo-5-fluoro-4-nitro-phenylamine 2-BroMo-5-fluoro-4-nitroaniline 952664-69-6