PNU 100480
- CAS No.
- 168828-58-8
- Chemical Name:
- PNU 100480
- Synonyms
- Sutezolid;U-480;U-603;CS-2604;U-100480;PNU-1603;U-101244;U-101603;PNU 100480;PF-2341272
- CBNumber:
- CB32628274
- Molecular Formula:
- C16H20FN3O3S
- Molecular Weight:
- 353.41
- MDL Number:
- MFCD00937821
- MOL File:
- 168828-58-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 186-187°C |
|---|---|
| Boiling point | 609.0±55.0 °C(Predicted) |
| Density | 1.321±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble20mg/mL, clear |
| pka | 15.53±0.46(Predicted) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -8 to -12°, c = 1 in chloroform-d |
| InChI | 1S/C16H20FN3O3S/c1-11(21)18-9-13-10-20(16(22)23-13)12-2-3-15(14(17)8-12)19-4-6-24-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1 |
| InChIKey | FNDDDNOJWPQCBZ-ZDUSSCGKSA-N |
| SMILES | FC1=CC(N(C[C@H](CNC(C)=O)O2)C2=O)=CC=C1N3CCSCC3 |
| FDA UNII | 3A71182L8P |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
PNU 100480 price More Price(41)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0035 | Sutezolid ≥98% (HPLC) | 168828-58-8 | 5mg | $129 | 2026-04-30 | Buy |
| Sigma-Aldrich | PZ0035 | Sutezolid ≥98% (HPLC) | 168828-58-8 | 25mg | $483 | 2024-03-01 | Buy |
| Cayman Chemical | 28395 | PNU 100480 ≥98% | 168828-58-8 | 5mg | $95 | 2026-04-30 | Buy |
| Cayman Chemical | 28395 | PNU 100480 ≥98% | 168828-58-8 | 10mg | $168 | 2026-04-30 | Buy |
| Cayman Chemical | 28395 | PNU 100480 ≥98% | 168828-58-8 | 25mg | $347 | 2026-04-30 | Buy |
PNU 100480 Chemical Properties,Uses,Production
Description
PNU 100480 is an oxazolidinone antibiotic that is active against multidrug resistant tuberculosis. It inhibits the growth of M. tuberculosis replicating and nonreplicating strains (MIC = ~400 ng/ml for both) and of clinical isolates that are susceptible or resistant to a combination of isoniazid , rifampin (rifampicin; ), ethambutol , and streptomycin (; MICs = ≤0.0625-0.5 mg/L). It also inhibits the growth of P. insidiosum and P. aphanidermatum clinical isolates (MICs = 4-64 μg/ml). PNU 100480 (100 mg/kg per day) decreases the number of colony forming units (CFU) in the lung in a mouse model of systemic nonreplicating M. tuberculosis infection.
Uses
Sutezolid is an oxazolidinone antibacterial agent analog. Sutezolid is a promising antimycobacterial agent (tuberculostatic).
Biochem/physiol Actions
Sutezolid (PNU 100480) is an oxazolidinone antimicrobial. Sutezolid inhibits protein synthesis by inhibiting bacterial mRNA translation. Sutezolid is being investigated for the treatment of multiple drug–resistant and extensively drug-resistant tuberculosis. The compound is a less toxic and more potent derivative of linezolid.
in vivo
Sutezolid (PNU-100480) is a thiomorpholinyl analog of linezolid with superior efficacy against M. tuberculosis in the hollow-fiber, mouse, and whole-blood models[3].
IC 50
Oxazolidinone
References
[1] J W C ALFFENAAR. Susceptibility of clinical Mycobacterium tuberculosis isolates to a potentially less toxic derivate of linezolid, PNU-100480.[J]. Antimicrobial Agents and Chemotherapy, 2011, 55 3: 1287-1289. DOI: 10.1128/aac.01297-10
[2] MING ZHANG. In vitro and in vivo activities of three oxazolidinones against nonreplicating Mycobacterium tuberculosis.[J]. Antimicrobial Agents and Chemotherapy, 2014: 3217-3223. DOI: 10.1128/aac.02410-14
[3] ERICO S LORETO. In Vitro Activities of Miltefosine and Antibacterial Agents from the Macrolide, Oxazolidinone, and Pleuromutilin Classes against Pythium insidiosum and Pythium aphanidermatum.[J]. Antimicrobial Agents and Chemotherapy, 2018, 62 3. DOI: 10.1128/aac.01678-17
PNU 100480 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 997 | 58 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| Nanjing XiZe Biotechnology CO., Ltd. | 025-66023220 15250997978 | 1511893459@qq.com | China | 4777 | 55 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4975 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Kaixin Chemical (Hong Kong) Limited | 010-88886666-01 13112345678 | loyson@qq.com | China | 589 | 55 |
