3-BroMo-5-cyanobenzoic acid Methyl ester
- CAS No.
- 453566-15-9
- Chemical Name:
- 3-BroMo-5-cyanobenzoic acid Methyl ester
- Synonyms
- Methyl 3-BroMo-5-cyanobenzoate;Methyl-5-bromo-3-cyanobenzoate;3-BroMo-5-cyanobenzoic acid Methyl ester;Benzoic acid, 3-broMo-5-cyano-, Methyl ester;3-Bromo-5-cyanobenzoic acid methyl ester 97%
- CBNumber:
- CB32670804
- Molecular Formula:
- C9H6BrNO2
- Molecular Weight:
- 240.05
- MDL Number:
- MFCD16620379
- MOL File:
- 453566-15-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H319-H331-H335-H302+H312 |
| Precautionary statements | P261-P280-P311-P305+P351+P338 |
| HS Code | 2916399090 |
3-BroMo-5-cyanobenzoic acid Methyl ester price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR321015 | 3-Bromo-5-cyanobenzoic acid methyl ester 97% | 453566-15-9 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR321015 | 3-Bromo-5-cyanobenzoic acid methyl ester 97% | 453566-15-9 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR321015 | 3-Bromo-5-cyanobenzoic acid methyl ester 97% | 453566-15-9 | 1g | $32 | 2026-06-04 | Buy |
| Apolloscientific | OR321015 | 3-Bromo-5-cyanobenzoic acid methyl ester 97% | 453566-15-9 | 5g | $150 | 2026-06-04 | Buy |
| Apolloscientific | OR321015 | 3-Bromo-5-cyanobenzoic acid methyl ester 97% | 453566-15-9 | 25g | $636 | 2026-06-04 | Buy |
3-BroMo-5-cyanobenzoic acid Methyl ester Chemical Properties, Uses, Production
Synthesis
1427407-54-2
453566-15-9
General procedure: methyl 3-bromo-5-carbamoylbenzoate (2.8 g, 10.8 mmol, 1.0 eq.) was dissolved in POCl3 (30 mL) and the reaction mixture was heated to reflux at 100 °C overnight. After completion of the reaction, POCl3 was removed by distillation under reduced pressure, the residue was diluted with water and the aqueous phase was extracted with EtOAc (3 x 30 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate, 20:1) to afford methyl 3-bromo-5-cyanobenzoate (2.5 g, 96% yield). The product was dissolved in THF (30 mL), LiOH-H2O (1.7 g, 41.6 mmol, 1.54 eq.) and H2O (10 mL) were added and stirred at room temperature overnight. After completion of the reaction, THF was removed under reduced pressure and the aqueous phase was acidified to pH 2-3 with dilute HCl and extracted with EtOAc (3 × 30 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (CH2Cl2/MeOH, 50:1) to afford methyl 3-bromo-5-cyanobenzoate as a white solid (2 g, 85% yield).LC-MS: m/z 248.0, 249.9 [M + Na]+. 1H NMR (400 MHz, DMSO) δ 13.67 (br s, 1H), 8.40 (s , 1H), 8.24 (s, 1H), 8.24 (s, 1H).
References
[1] Patent: WO2013/37705, 2013, A2. Location in patent: Page/Page column 139
3-BroMo-5-cyanobenzoic acid Methyl ester Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
| Changzhou Anxuan Chemical, Co., Ltd. | 13912302692 | sales@anxuanchem.com | China | 4824 | 58 |
| Nanjing Chempioneer Pharmaceutical Co., Ltd. | 18068075658 | sales@chempioneer.com | China | 1803 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | sales@changyanchem.cn | China | 4998 | 55 |
| Changzhou Hopschain Chemical Co.,Ltd. | 85528066 13775048983 | sales@hopschem.com | China | 31548 | 55 |
View Latest Price from 3-BroMo-5-cyanobenzoic acid Methyl ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-31 | 3-BroMo-5-cyanobenzoic acid Methyl ester
453566-15-9
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 3-BroMo-5-cyanobenzoic acid Methyl ester
453566-15-9
- $1.00
- 99%
- Career Henan Chemical Co
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