Methyl 3-bromo-4-methylbenzoate
- CAS No.
- 104901-43-1
- Chemical Name:
- Methyl 3-bromo-4-methylbenzoate
- Synonyms
- Methyl 3-bromo-4-met;METHYL 4-BROMO-M-TOLUATE;METHYL 3-BROMO-P-TOLUATE;METHYL 3-BROMO-4-METHYLBENZOATE;3-BROMO-4-METHYL METHYL BENZOATE;Methyl3-Bromo-4-methylbenzoate>3-BroMo-p-toluic acid Methyl ester;4-BROMO-M-TOLUIC ACID METHYL ESTER;Methyl 3-bromo-4-methylbenzoate ,98%;4-BROMO-3-METHYLBENZOIC ACID METHYL ESTER
- CBNumber:
- CB8724371
- Molecular Formula:
- C9H9BrO2
- Molecular Weight:
- 229.07
- MDL Number:
- MFCD00144769
- MOL File:
- 104901-43-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 38-44 °C(lit.) |
|---|---|
| Boiling point | 130°C/0.1mmHg(lit.) |
| Density | 1.433±0.06 g/cm3(Predicted) |
| refractive index | 1.5570 to 1.5610 |
| Flash point | >230 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in dimethyl sulfoxide. |
| form | clear liquid |
| color | Colorless to Light orange to Yellow |
| InChI | InChI=1S/C9H9BrO2/c1-6-3-4-7(5-8(6)10)9(11)12-2/h3-5H,1-2H3 |
| InChIKey | MASRAGFWFYHMFI-UHFFFAOYSA-N |
| SMILES | C(OC)(=O)C1=CC=C(C)C(Br)=C1 |
| CAS DataBase Reference | 104901-43-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2916399090 | |||||||||
| NFPA 704 |
|
Methyl 3-bromo-4-methylbenzoate price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2181 | Methyl 3-Bromo-4-methylbenzoate >98.0%(GC) | 104901-43-1 | 5g | $31 | 2026-04-30 | Buy |
| TCI Chemical | M2181 | Methyl 3-Bromo-4-methylbenzoate >98.0%(GC) | 104901-43-1 | 25g | $91 | 2026-04-30 | Buy |
| Usbiological | 283664 | Methyl 3-bromo-4-methylbenzoate Asreported | 104901-43-1 | 2g | $296 | 2026-06-03 | Buy |
| Usbiological | 283664 | Methyl 3-bromo-4-methylbenzoate Asreported | 104901-43-1 | 5g | $396 | 2026-06-03 | Buy |
| Usbiological | 283664 | Methyl 3-bromo-4-methylbenzoate Asreported | 104901-43-1 | 10g | $515 | 2026-06-03 | Buy |
Methyl 3-bromo-4-methylbenzoate Chemical Properties, Uses, Production
Chemical Properties
Orange-red solid
Uses
It is a pharmaceutical intermediate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 53, p. 5545, 1988 DOI: 10.1021/jo00258a030
Synthesis
67-56-1
7697-26-9
104901-43-1
The general procedure for the synthesis of methyl 3-bromo-4-methylbenzoate from methanol and 3-bromo-4-methylbenzoic acid was as follows: 3-bromo-4-methylbenzoic acid (2.0 g, 9.30 mmol) was suspended in methanol (20 ml), and sulfuric acid (0.04 ml) was added as a catalyst. The reaction mixture was stirred at 60°C for 42 hours. After completion of the reaction, the reaction mixture was concentrated and the residue was dissolved in ethyl acetate. The organic phase was washed with saturated aqueous sodium bicarbonate, dried over anhydrous magnesium sulfate, filtered and concentrated to afford the title compound methyl 3-bromo-4-methylbenzoate as an orange oil (2.25 g, quantitative yield), which could be used for subsequent experiments without further purification.
References
[1] Patent: US2013/237537, 2013, A1. Location in patent: Paragraph 0330-0331
[2] Patent: WO2013/119946, 2013, A1. Location in patent: Paragraph 0198; 0345
[3] Patent: WO2011/107608, 2011, A1. Location in patent: Page/Page column 69
[4] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 23, p. 6442 - 6446
[5] Patent: WO2006/4903, 2006, A2. Location in patent: Page/Page column 125
Methyl 3-bromo-4-methylbenzoate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShangHai ZiCheng Med-Pharm Technology Company Ltd. | 021-56710790 18721468858 | wangyh@fudan.edu.cn | China | 26 | 55 |
| Xinyi Kangda Biological Technology Co., Ltd. | 16503038585 | xinyikangda@163.com | China | 610 | 58 |
| Jinan Yaode Biotechnology Co., Ltd | 17805033575; 17805033575 | baiyu1.618@163.com | China | 391 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from Methyl 3-bromo-4-methylbenzoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-27 | Methyl 3-bromo-4-methylbenzoate
104901-43-1
|
1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | ||
 |
2019-07-06 | Methyl 3-bromo-4-methylbenzoate
104901-43-1
|
$1.00 | 1KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
-
- Methyl 3-bromo-4-methylbenzoate
104901-43-1
- $0.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Methyl 3-bromo-4-methylbenzoate
104901-43-1
- $1.00
- 98%
- Career Henan Chemical Co
