2-Fluoro-4-hydroxybenzonitrile
- CAS No.
- 82380-18-5
- Chemical Name:
- 2-Fluoro-4-hydroxybenzonitrile
- Synonyms
- FCP;422-810-7;Compound Fr13697;2-Fluoro-4-hydroxybe;4-CYANO-3-FLUOROPHENOL;3-FLUORO-4-CYANOPHENOL;3-Fluoro-p-cyanophenol;3-fluoro-4-cyanopehenol;2-FLUORO-4-BENZONITRILE;3-FORMYL-5-BROMOPYRIDINE
- CBNumber:
- CB3273490
- Molecular Formula:
- C7H4FNO
- Molecular Weight:
- 137.11
- MDL Number:
- MFCD00192177
- MOL File:
- 82380-18-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 2-Fluoro-4-hydroxybenzonitrile >98.0%(GC)(T) | F0462 | 5g | $23 |
| 2-Fluoro-4-hydroxybenzonitrile >98.0%(GC)(T) | F0462 | 25g | $87 |
| 2-Fluoro-4-hydroxybenzonitrile ≥98%(GC) | 46114 | 5G | $23.6 |
| 2-Fluoro-4-hydroxybenzonitrile ≥98%(GC) | 46114 | 25G | $76.5 |
| 2-Fluoro-4-hydroxybenzonitrile | 002534 | 25.00g | $25 |
| More product size | |||
| Melting point | 123-125 °C (lit.) |
|---|---|
| Boiling point | 285.4±25.0 °C(Predicted) |
| Density | 1,45 g/cm3 |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 4.7g/l |
| pka | 6.84±0.18(Predicted) |
| form | powder to crystal |
| color | White to Almost white |
| PH | 4.2 (H2O, 20℃)(saturated aqueous solution) |
| BRN | 4741066 |
| InChI | InChI=1S/C7H4FNO/c8-7-3-6(10)2-1-5(7)4-9/h1-3,10H |
| InChIKey | REIVHYDACHXPNH-UHFFFAOYSA-N |
| SMILES | C(#N)C1=CC=C(O)C=C1F |
| CAS DataBase Reference | 82380-18-5(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS09,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H401-H302-H318-H411-H315-H319 | |||||||||
| Precautionary statements | P273-P280-P305+P351+P338-P264-P270-P301+P312+P330-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P501-P280i-P301+P312a-P310a-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi,T | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | 2 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 9 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29269095 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Aquatic Chronic 2 Eye Dam. 1 |
|||||||||
| REACH Registrations | Inactive | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
2-Fluoro-4-hydroxybenzonitrile price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0462 | 2-Fluoro-4-hydroxybenzonitrile >98.0%(GC)(T) | 82380-18-5 | 5g | $23 | 2026-04-30 | Buy |
| TCI Chemical | F0462 | 2-Fluoro-4-hydroxybenzonitrile >98.0%(GC)(T) | 82380-18-5 | 25g | $87 | 2026-04-30 | Buy |
| Chem-Impex | 46114 | 2-Fluoro-4-hydroxybenzonitrile ≥98%(GC) | 82380-18-5 | 5G | $23.6 | 2026-05-19 | Buy |
| Chem-Impex | 46114 | 2-Fluoro-4-hydroxybenzonitrile ≥98%(GC) | 82380-18-5 | 25G | $76.5 | 2026-05-19 | Buy |
| Matrix Scientific | 002534 | 2-Fluoro-4-hydroxybenzonitrile | 82380-18-5 | 25.00g | $25 | 2026-05-18 | Buy |
2-Fluoro-4-hydroxybenzonitrile Chemical Properties,Uses,Production
Chemical Properties
Off-white Cryst
Uses
2-Fluoro-4-hydroxybenzonitrile may be used in the synthesis of 4-cyano-3-fluorophenyl 4-(hexadecyloxy) benzoate.
Uses
Intermediates of Liquid Crystals
General Description
2-Fluoro-4-hydroxybenzonitrile is a planar molecule. Its mol-ecules are arranged in linear chains via weak intermolecular O-HN hydrogen bonds.
Synthesis
105942-08-3
82380-18-5
General procedure for the synthesis of 2-fluoro-4-hydroxybenzonitrile from 4-bromo-2-fluorobenzonitrile: 4-bromo-2-fluorobenzonitrile (0.25 mmol), copper bromide (0.03 mmol), triethylamine (0.25 mmol, 1.0 eq.), formic acid (0.75 mmol, 3.0 eq.), and acetonitrile (179 mmol) were added to a reaction flask at room temperature. were used as reaction solvents. The reaction mixture was stirred at room temperature for 24 h under oxygen atmosphere. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, water (20 mL) and ethyl acetate (10 mL) were added to the reaction mixture for extraction, and the organic phases were combined and dried over anhydrous sodium sulfate. The dried organic phase was filtered and the filter cake was washed with ethyl acetate (5 mL × 3 times). Subsequently, the solvent was removed by rotary evaporator. The crude product was purified by column chromatography (eluent ratio: petroleum ether/ethyl acetate = 6:1) to afford the target product 2-fluoro-4-hydroxybenzonitrile in yellow liquid form in 82% yield.
References
[1] Organic Letters, 2018, vol. 20, # 3, p. 708 - 711
[2] Patent: CN107915586, 2018, A. Location in patent: Paragraph 0097-0100
2-Fluoro-4-hydroxybenzonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yantai Fenglu Fine Chemical Co. LTD | +86-+undefined-008618315825527 | kevin.wang@xhtechgroup.com | China | 122 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8738 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20124 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13901 | 58 |
| Shanghai Bojing Chemical Co.,Ltd. | +86-86-02137122233 +8613795318958 | bj1@bj-chem.com | China | 299 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21588 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29815 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10404 | 58 |
View Lastest Price from 2-Fluoro-4-hydroxybenzonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-03-20 | 2-Fluoro-4-hydroxybenzonitrile
82380-18-5
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-09-25 | 2-Fluoro-4-hydroxybenzonitrile
82380-18-5
|
US $8.00-0.60 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2025-04-04 | 2-Fluoro-4-hydroxybenzonitrile
82380-18-5
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 2-Fluoro-4-hydroxybenzonitrile
82380-18-5
- US $1.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 2-Fluoro-4-hydroxybenzonitrile
82380-18-5
- US $8.00-0.60 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Fluoro-4-hydroxybenzonitrile
82380-18-5
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
