5-Methyl-1H-pyrrolo[2,3-b]pyridine
![5-Methyl-1H-pyrrolo[2,3-b]pyridine Structure](CAS/GIF/824-52-2.gif)
- CAS No.
- 824-52-2
- Chemical Name:
- 5-Methyl-1H-pyrrolo[2,3-b]pyridine
- Synonyms
- 5-METHYL-7-AZAINDOLE;5-Methyl-1H-pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-methyl-
- CBNumber:
- CB3279018
- Molecular Formula:
- C8H8N2
- Molecular Weight:
- 132.16
- MDL Number:
- MFCD06659674
- MOL File:
- 824-52-2.mol
- MSDS File:
- SDS
| Melting point | 138-139 °C |
|---|---|
| Boiling point | 365.4±15.0 °C(Predicted) |
| Density | 1.17±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| form | solid |
| pka | 7.94±0.20(Predicted) |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C8H8N2/c1-6-4-7-2-3-9-8(7)10-5-6/h2-5H,1H3,(H,9,10) |
| InChIKey | DJCJHFFRHKGOCQ-UHFFFAOYSA-N |
| SMILES | C12NC=CC1=CC(C)=CN=2 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H315-H318 |
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22-38-41 |
| Safety Statements | 26-39 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 |
5-Methyl-1H-pyrrolo[2,3-b]pyridine price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000939 | 5-Methyl-1H-pyrrolo[2,3-b]pyridine Aldrich | 824-52-2 | 1g | $870 | 2026-04-30 | Buy |
| Usbiological | 282522 | 5-Methyl-1H-pyrrolo[2,3-b]pyridine Asreported | 824-52-2 | 50mg | $460 | 2026-06-03 | Buy |
| Usbiological | 282522 | 5-Methyl-1H-pyrrolo[2,3-b]pyridine Asreported | 824-52-2 | 100mg | $705 | 2026-06-03 | Buy |
| Usbiological | 282522 | 5-Methyl-1H-pyrrolo[2,3-b]pyridine Asreported | 824-52-2 | 250mg | $1094 | 2026-06-03 | Buy |
| Usbiological | 282522 | 5-Methyl-1H-pyrrolo[2,3-b]pyridine Asreported | 824-52-2 | 500mg | $1742 | 2026-06-03 | Buy |
5-Methyl-1H-pyrrolo[2,3-b]pyridine Chemical Properties, Uses, Production
Chemical Properties
5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE is Light yellow solid
Uses
5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE is an intermediate for preparation of pyrrolopyridine compounds as protein kinase modulators useful in treatment of diseases associated with aberrant activity of protein kinases.
Synthesis
500903-95-7
![5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE](/CAS/GIF/824-52-2.gif)
824-52-2
The general procedure for the synthesis of 5-methyl-7-azaindole from 5-methyl-3-((trimethylmethylsilyl)alkynyl)pyridin-2-amine was as follows: 5-methyl-3-((trimethylsilyl)alkynyl)pyridin-2-amine (9.8 g, 48.0 mmol) and N-methylpyrrolidinone (50 mL) were added to a dry three-necked flask. Under ice bath conditions, sodium hydride (60% dispersed in mineral oil, 2.8 g, 59 mmol) was slowly added, followed by heating the reaction mixture to 100 degrees Celsius and holding for 10 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and saturated ammonium chloride solution (50 mL) was slowly added to quench the reaction. Extraction was performed with ethyl acetate (50 mL x 3) and the organic phases were combined. The organic phase was washed sequentially with water (100 mL) and saturated brine (100 mL) and then dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated to dryness in a rotary evaporator to obtain the crude product. The crude product was recrystallized with ethyl acetate (10 mL) to give 5-methyl-7-azaindole (5.1 g, 38.6 mmol, 80% yield) as a white solid.
References
[1] Patent: CN107056781, 2017, A. Location in patent: Paragraph 0008
[2] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 120
[3] Patent: US2009/253679, 2009, A1. Location in patent: Page/Page column 41
[4] Patent: WO2008/4117, 2008, A1
5-Methyl-1H-pyrrolo[2,3-b]pyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Jinyin Biological Technology Co., Ltd | 021-20986266 18019349802 | 814527417@qq.com | China | 461 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3828 | 58 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3981 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
View Latest Price from 5-Methyl-1H-pyrrolo[2,3-b]pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/9a3210f6-1e6d-46aa-9608-7da605718344.jpg) |
2019-12-20 | 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
824-52-2
|
$1.00 | 1KG | 99% | 1000KGS | Career Henan Chemical Co |
-
- 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
824-52-2
- $1.00
- 99%
- Career Henan Chemical Co
824-52-2 (5-Methyl-1H-pyrrolo[2,3-b]pyridine) Related Search:
1of4
