1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid
![1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid Structure](CAS/GIF/754214-42-1.gif)
- CAS No.
- 754214-42-1
- Chemical Name:
- 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid
- Synonyms
- 7-Azaindole-5-carboxylic ...;7-AZAINDOLE-5-CARBOXYLIC ACID;7-Azaindole-5-carboxylic acid 97%;1H-Pyrrolo[2,3-b]pyridin-5-carboxylic acid;1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid;4-(Di-n-propylsulfamoyl)benzeneboronic acid;1H-Pyrrolo[2,3-b]pyridine-5-carbo×ylic acid
- CBNumber:
- CB5774744
- Molecular Formula:
- C8H6N2O2
- Molecular Weight:
- 162.15
- MDL Number:
- MFCD08272240
- MOL File:
- 754214-42-1.mol
- MSDS File:
- SDS
| storage temp. | Sealed in dry,Room Temperature |
|---|---|
| form | solid |
| Appearance | White to light yellow Solid |
| InChI | InChI=1S/C8H6N2O2/c11-8(12)6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10)(H,11,12) |
| InChIKey | SINFYKZXNIJIEU-UHFFFAOYSA-N |
| SMILES | C12NC=CC1=CC(C(O)=O)=CN=2 |
| UNSPSC Code | 12352106 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P301+P312-P302+P352 |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26-24/25 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
| Storage Class | 11 - Combustible Solids |
1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000888 | 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid Aldrich | 754214-42-1 | 1g | $870 | 2026-04-30 | Buy |
| Apolloscientific | OR40241 | 7-Azaindole-5-carboxylic acid 97% | 754214-42-1 | 1g | $39 | 2026-06-04 | Buy |
| Apolloscientific | OR40241 | 7-Azaindole-5-carboxylic acid 97% | 754214-42-1 | 5g | $143 | 2026-06-04 | Buy |
| Apolloscientific | OR40241 | 7-Azaindole-5-carboxylic acid 97% | 754214-42-1 | 10g | $264 | 2026-06-04 | Buy |
| Matrix Scientific | 026198 | 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid | 754214-42-1 | 5.00g | $85 | 2026-05-18 | Buy |
1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid Chemical Properties, Uses, Production
Chemical Properties
White solid
Uses
1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid is used in pharmaceutical synthesis and experimental research.
Synthesis
![1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 1-[(1,1-dimethylethyl)dimethylsilyl]-](/CAS/GIF/754214-41-0.gif)
754214-41-0
![1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID](/CAS/GIF/754214-42-1.gif)
754214-42-1
The general procedure for the synthesis of 7-azaindole-5-carboxylic acid from the compound (CAS: 754214-41-0) was as follows: the crude acid 10 was dissolved in dichloromethane (5 mL), and DDQ was added in batches until TLC analysis showed complete consumption of the starting material. The reaction mixture was concentrated to give a solid residue containing azaindole 11. The residue was dissolved in 5% HCl in methanol solution (5 mL) and stirred for 1.5 hours at room temperature. After completion of the reaction, the mixture was concentrated and diluted with chloroform and saturated saline. The mixture was alkalized to pH 11 with 50% NaOH solution and the organic layer was discarded. The aqueous layer was neutralized with 6 M HCl and extracted with ethyl acetate (4 times). The organic extracts were combined, dried with magnesium sulfate, filtered and concentrated. The residue was purified by preparative thin layer chromatography (PTLC) using dichloromethane: methanol = 9:1 as eluent to give 7-azaindole-5-carboxylic acid 12 (3.19 mg, 3% overall yield in three steps). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 6.58 (d, J = 3.5 Hz, 1H), 7.42 (d, J = 3.5 Hz, 1H), 8.58 (d, J = 2.0 Hz, 1H), 8.85 (d, J = 1.7 Hz, 1H).
References
[1] Patent: WO2004/78757, 2004, A2. Location in patent: Page 53-55
1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang suchen Chemical Technology Co. LTD | 186-33933494 18032288352 | 1130239@qq.com | China | 192 | 60 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| SpringPharma Tech Co.,Ltd | +86-25-68710855, +86-25-68710897 | sales@springpharma.net | China | 1260 | 62 |
| Wuhan ariel chemical Co., LTD. | 18986259541 18986259541 | sales@3stc.com | China | 3830 | 58 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3987 | 55 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
View Latest Price from 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID pictures](https://img.chemicalbook.com/ProductImageEN/2019-8/Small/749ae852-fb61-4b5b-ba66-8a625c577daa.png) |
2019-08-06 | 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID
754214-42-1
|
$8.80 | 1KG | 97%-99% | 100kg | Career Henan Chemical Co |
-
- 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID
754214-42-1
- $8.80
- 97%-99%
- Career Henan Chemical Co
754214-42-1 (1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid) Related Search:
1of4
