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CP 376395 hydrochloride

CP 376395 hydrochloride Structure
CP 376395 hydrochloride structure
CAS No.
1013933-37-3
Chemical Name:
CP 376395 hydrochloride
Synonyms
CP-376395 HCl;UNII-5113G7FP34;CP 376395 HCl,CP376395 HCl;CP 376395 hydrochloride (CP376395;CP-376395 hydrochloride >=98% (HPLC);4-Pyridinamine, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-, hydrochloride (1:1)
CBNumber:
CB33136798
Molecular Formula:
C21H30N2O.ClH
Molecular Weight:
362.94
MDL Number:
MFCD11519966
MOL File:
1013933-37-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:50:20
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CP 376395 hydrochloride Properties

storage temp. Desiccate at RT
solubility Soluble to 50 mM in water and to 100 mM in DMSO
form Powder
color white to beige
InChI 1S/C21H30N2O.ClH/c1-8-18(9-2)23-19-12-16(6)22-21(17(19)7)24-20-14(4)10-13(3)11-15(20)5;/h10-12,18H,8-9H2,1-7H3,(H,22,23);1H
InChIKey UDIOZDHQQNYISB-UHFFFAOYSA-N
SMILES CC1=C(NC(CC)CC)C=C(C)N=C1OC2=C(C)C=C(C)C=C2C.[H]Cl
UNSPSC Code 12352200
NACRES NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P305+P351+P338
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

CP 376395 hydrochloride price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PZ0365 CP-376395 hydrochloride ≥98% (HPLC) 1013933-37-3 25 mg $467 2026-04-30 Buy
Usbiological 445089 CP 376395 Hydrochloride 1013933-37-3 1mg $389 2026-06-03 Buy
Usbiological 445089 CP 376395 Hydrochloride 1013933-37-3 2.5mg $638 2026-06-03 Buy
Usbiological 255037 CP 376395 hydrochloride Asreported 1013933-37-3 10mg $466 2026-06-03 Buy
Usbiological 255037 CP 376395 hydrochloride Asreported 1013933-37-3 50mg $1281 2026-06-03 Buy
Product number Packaging Price Buy
PZ0365 25 mg $467 Buy
445089 1mg $389 Buy
445089 2.5mg $638 Buy
255037 10mg $466 Buy
255037 50mg $1281 Buy

CP 376395 hydrochloride Chemical Properties, Uses, Production

Description

Potent and selective CRF1receptor antagonist (Kivalues are 12 and >10000 nM for CRF1and CRF2receptors respectively). Attenuates CRF-induced activation of the HPA axisin vivofollowing i.v. administration. Orally active.

Uses

CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist[1][2].

in vivo

CP 376395 (10-20 mg/kg, i.p., Male B6 mice) attenuates H2O and food intake, increases sucrose intake, attenuates EtOH intake but not EtOH preference[2].

Animal Model:Male B6 mice (n=8-9 per group)[2]
Dosage:0.0, 10.0, or 20.0 mg/kg
Administration:Intraperitoneally
Result:Dose-dependently attenuated intake of H2O and food, with H2O intake affected specifically during the first half of the session.

IC 50

CRFR1; CRFR2

storage

Desiccate at RT

References

[1] Chen YL, et al. 2-aryloxy-4-alkylaminopyridines: discovery of novel corticotropin-releasing factor 1 antagonists. J Med Chem. 2008 Mar 13;51(5):1385-92. DOI:10.1021/jm070579c
[2] Giardino WJ, et al. CRF1 receptor signaling regulates food and fluid intake in the drinking-in-the-dark model of binge alcohol consumption. Alcohol Clin Exp Res. 2013 Jul;37(7):1161-70. DOI:10.1111/acer.12076

CP 376395 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

CP 376395 hydrochloride Suppliers

Global Suppliers ( 12)
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Energy Chemical 400-0056266 marketing1@energy-chemical.com China 44927 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 5000 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5985 58
Aladdin Scientific tp@aladdinsci.com United States 50068 58
TargetMol Chemicals Inc. +1-781-999-5354; support@targetmol.com United States 38999 58
Supplier Advantage
BOC Sciences 58
TargetMol Chemicals Inc. 58
Energy Chemical 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Aladdin Scientific 58
TargetMol Chemicals Inc. 58

View Latest Price from CP 376395 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CP-376395 HCl pictures 2025-12-22 CP-376395 HCl
1013933-37-3
 10g TargetMol Chemicals Inc.

1013933-37-3 (CP 376395 hydrochloride) Related Search:

CP 376395 hydrochloride CP 376395 NA Tetracosactide acetate CRF (HUMAN, RAT)
Sauvagine TFA

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CP-376395 HCl CP 376395 hydrochloride (CP376395 CP-376395 hydrochloride >=98% (HPLC) UNII-5113G7FP34 CP 376395 HCl,CP376395 HCl 4-Pyridinamine, N-(1-ethylpropyl)-3,6-dimethyl-2-(2,4,6-trimethylphenoxy)-, hydrochloride (1:1) 1013933-37-3 C21H30N2OHCl