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Benzo[b]thiophene-3-carbonitrile

Benzo[b]thiophene-3-carbonitrile Structure
Benzo[b]thiophene-3-carbonitrile structure
CAS No.
24434-84-2
Chemical Name:
Benzo[b]thiophene-3-carbonitrile
Synonyms
BUTTPARK 147\16-61;3-CYANOBENZO[B]THIOPHENE;3-Cyano-1-benzothiophene;Benzothiophene-3-nitrile;Benzothiophene-3-carbonitrile;1-BENZOTHIOPHENE-3-CARBONITRILE;Benzo[b]thiophene-3-carbonitrile;Benzo[b]thiophene-3-carbonitrile 97%;Benzo(b)thiophene-3-carbonitrile ,97%;Benzo[b]thiophene-3-carbonitrile
CBNumber:
CB4294571
Molecular Formula:
C9H5NS
Molecular Weight:
159.21
MDL Number:
MFCD08276872
MOL File:
24434-84-2.mol
MSDS File:
SDS
Last updated:2026-09-12 18:52:44
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Benzo[b]thiophene-3-carbonitrile Properties

Melting point 71-75 °C
Boiling point 312.7±15.0 °C(Predicted)
Density 1.28±0.1 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
Appearance White to light yellow Solid
InChI 1S/C9H5NS/c10-5-7-6-11-9-4-2-1-3-8(7)9/h1-4,6H
InChIKey WBXHAYDGMCONLX-UHFFFAOYSA-N
SMILES N#Cc1csc2ccccc12
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn
Risk Statements  22-36/37/38
Safety Statements  26
WGK Germany  3
HS Code  29349990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

Benzo[b]thiophene-3-carbonitrile price More Price(50)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 665975 Benzo[b]thiophene-3-carbonitrile 97% 24434-84-2 1g $73 2023-06-20 Buy
Apolloscientific OR913339 Benzo[b]thiophene-3-carbonitrile >98% 24434-84-2 250mg $21 2026-06-04 Buy
Apolloscientific OR913339 Benzo[b]thiophene-3-carbonitrile >98% 24434-84-2 1g $26 2026-06-04 Buy
Apolloscientific OR913339 Benzo[b]thiophene-3-carbonitrile >98% 24434-84-2 5g $115 2026-06-04 Buy
Apolloscientific OR913339 Benzo[b]thiophene-3-carbonitrile >98% 24434-84-2 25g $553 2026-06-04 Buy
Product number Packaging Price Buy
665975 1g $73 Buy
OR913339 250mg $21 Buy
OR913339 1g $26 Buy
OR913339 5g $115 Buy
OR913339 25g $553 Buy

Benzo[b]thiophene-3-carbonitrile Chemical Properties, Uses, Production

Chemical Properties

White to light brown solid

Synthesis

1-Benzothiophene-3-carbaldehyde

5381-20-4

BENZO[B]THIOPHENE-3-CARBONITRILE

24434-84-2

General procedure for the synthesis of benzo[b]thiophene-3-carbonitrile from 3-formylbenzothiophene: To a premixed mixed solution of hexafluoroisopropanol (HFIP) and acetonitrile (ACN) (2.0 mL, 1:1) under nitrogen protection was added aromatic aldehyde 1 (0.500 mmol, 1.0 equiv.) and trimethylsilyl azide (TMSN3; 115 mg, 1.00 mmol, 2.0 equiv). Subsequently, trifluoromethanesulfonic acid (TfOH; 17.7 μL, 0.200 mmol, 0.40 eq.) was added to two dry vials, and exothermic and rapid foaming phenomena due to gas production were immediately observed. The vial was quickly capped and the reaction mixture was stirred at room temperature for 20 to 75 min. Upon completion of the reaction, the reaction mixture was concentrated under nitrogen atmosphere. The obtained residue was suspended in a solvent mixture of dichloromethane (CH2Cl2) and hexane and loaded through a sample cassette containing 5 g silica gel. Purification was carried out by normal-phase silica gel fast column chromatography using a CombiFlash purification system, and suitable elution fractions were collected and concentrated to give the target product benzo[b]thiophene-3-carbonitrile (2).

References

[1] Molecules, 2016, vol. 21, # 1,
[2] Organic and Biomolecular Chemistry, 2016, vol. 14, # 5, p. 1840 - 1840
[3] Tetrahedron Letters, 2013, vol. 54, # 17, p. 2177 - 2179
[4] Organic and Biomolecular Chemistry, 2015, vol. 13, # 30, p. 8322 - 8329

Benzo[b]thiophene-3-carbonitrile Preparation Products And Raw materials

Raw materials

Copper(I) Cyanide Thianaphthene Sodium acetate Chloroform Bromine
Pyridine 1-Benzothiophene-3-carbaldehyde 3-Bromo-1-benzothiophene Sodium cyanide Azidotrimethylsilane

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Preparation Products

Benzo[b]thiophene-3-carbonitrile Suppliers

Global Suppliers ( 63)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Nanjing Habo Medical Technology Co., Ltd. 13376080562 13376090521 sales@habotech.com China 726 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29985 65
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Chengdu RunZeBenTu Chemical Co., Ltd 028-88469284 18000562381; rzbtsj@163.com China 9939 56
Henan CoreyChem Co., Ltd 0371-86658258 info@coreychem.com China 10442 58
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Amatek Scientific Co. Ltd. 0512-56316828 400-867-5858;400-867-5858 info@amateksci.com China 28760 58
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Nanjing Habo Medical Technology Co., Ltd. 60
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Sigma-Aldrich 80
Chengdu RunZeBenTu Chemical Co., Ltd 56
Henan CoreyChem Co., Ltd 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Amadis Chemical Company Limited 58
Amatek Scientific Co. Ltd. 58

View Latest Price from Benzo[b]thiophene-3-carbonitrile manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
BENZO[B]THIOPHENE-3-CARBONITRILE pictures 2026-08-20 BENZO[B]THIOPHENE-3-CARBONITRILE
24434-84-2
 $1.10 1g 99.00% 100 Tons Dideu Industries Group Limited

Benzo[b]thiophene-3-carbonitrile Spectrum

BENZO[B]THIOPHENE-3-CARBONITRILE(24434-84-2)1HNMR

24434-84-2 (Benzo[b]thiophene-3-carbonitrile) Related Search:

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BUTTPARK 147\16-61 3-CYANOBENZO[B]THIOPHENE Benzothiophene-3-carbonitrile 1-BENZOTHIOPHENE-3-CARBONITRILE 3-Cyano-1-benzothiophene Benzo(b)thiophene-3-carbonitrile ,97% Benzothiophene-3-nitrile Benzo[b]thiophene-3-carbonitrile 97% BENZO[B]THIOPHENE-3-CARBONITRILE ISO 9001：2015 REACH Benzo[b]thiophene-3-carbonitrile benzenebenzo[b]thiophene-3-methylnitrile Benzo[b]thiophene-3-carbonitrile 24434-84-2 Benzothiophenes Building Blocks Chemical Synthesis Heterocyclic Building Blocks